Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Rosy Joshi-Mukherjee"'
Autor:
Stacie L. Edwards, Viviana Zlochiver, Donald B. Conrad, Ravi Vaidyanathan, Andrew M. Valiquette, Rosy Joshi-Mukherjee
Publikováno v:
Stem Cell Reports, Vol 11, Iss 2, Pp 522-536 (2018)
Summary: Multielectrode array (MEA) technology has been extensively used for field potential recordings from excitable cells. However, its application for action potential (AP) measurements has not been harnessed. Here, we report a novel platform for
Externí odkaz:
https://doaj.org/article/2729e4767b874a3da974c4cc7a3473d1
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Timothy Syndrome (TS) is a multisystem disorder caused by two mutations leading to dysfunction of the CaV1.2 channel. Here, Dick et al. uncover a major and mechanistically divergent effect of both mutations on Ca2+/calmodulin-dependent inactivation o
Externí odkaz:
https://doaj.org/article/e30e38494b244ba9928aab1ec875756a
Autor:
Rosy Joshi-Mukherjee, Andrew M. Valiquette, Donald B. Conrad, Ravi Vaidyanathan, Viviana Zlochiver, Stacie Edwards
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 11, Iss 2, Pp 522-536 (2018)
Stem Cell Reports, Vol 11, Iss 2, Pp 522-536 (2018)
Summary Multielectrode array (MEA) technology has been extensively used for field potential recordings from excitable cells. However, its application for action potential (AP) measurements has not been harnessed. Here, we report a novel platform for
Publikováno v:
Circulation Research. 125
Long-term action potential (AP) studies from the same cell site over days in multicellular preparations are currently lacking, thus limiting our understanding of cardiac physiology in development and disease. We recently reported a novel high-through
Autor:
Rosy Joshi-Mukherjee, Jonathan A. Cook, Christopher R. Beal, Stacie L. Kroboth, Viviana Zlochiver
Publikováno v:
Journal of Visualized Experiments.
Publikováno v:
Journal of Visualized Experiments.
Cardiac safety screening is of paramount importance for drug discovery and therapeutics. Therefore, the development of novel high-throughput electrophysiological approaches for hiPSC-derived cardiomyocyte (hiPSC-CM) preparations is much needed for ef
Publikováno v:
Circulation Research. 123
Multielectrode array technology utilizing iPSC derived cardiomyocytes has proven useful for drug screening and arrhythmia studies. However, its application for direct action potential (AP) measurements from multicellular preparations remains limiting
Publikováno v:
Biophysical Journal. 116:100a-101a
Autor:
Rosy Joshi-Mukherjee
Cardiovascular disease is the number one cause of death in the US. According to US Center for Disease Control and Prevention (CDC), about 800,000 American deaths is attributed to cardiovascular disease and each year about hundreds of thousands of peo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7915cc200adcc372424bea761b5bd269
https://zenodo.org/record/582584
https://zenodo.org/record/582584
Autor:
Ivy E. Dick, Michael Toft Overgaard, David T. Yue, Rosy Joshi-Mukherjee, Alfred L. George, Worawan B. Limpitikul
Publikováno v:
Limpitikul, W B, Dick, I E, Joshi-Mukherjee, R, Overgaard, M T, George, A L & Yue, D T 2014, ' Calmodulin Mutations Associated with Long QT Syndrome Prevent Inactivation of Cardiac L-type Ca(2+) Currents and Promote Proarrhythmic Behavior in Ventricular Myocytes ', Journal of Molecular and Cellular Cardiology, vol. 74, pp. 115-124 . https://doi.org/10.1016/j.yjmcc.2014.04.022
Recent work has identified missense mutations in calmodulin (CaM) that are associated with severe early-onset long-QT syndrome (LQTS), leading to the proposition that altered CaM function may contribute to the molecular etiology of this subset of LQT