Impact of mucus and biofilm on antimicrobial photodynamic therapy: Evaluation using Ruthenium(II) complexes

Autor: Raphaëlle Youf, Rosy Ghanem, Adeel Nasir, Gilles Lemercier, Tristan Montier, Tony Le Gall

Publikováno v: Biofilm, Vol 5, Iss , Pp 100113- (2023)

The biofilm lifestyle of bacterial pathogens is a hallmark of chronic lung infections such as in cystic fibrosis (CF) patients. Bacterial adaptation to the complex conditions in CF-affected lungs and repeated antibiotherapies lead to increasingly tol

Externí odkaz: https://doaj.org/article/082d4da7cf9c4997b8e1783f53de0bed

Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes

Autor: Tony Le Gall, Mathieu Berchel, Lee Davies, Angélique Mottais, Rosy Ghanem, Alain Fautrel, Deborah Gill, Steve Hyde, Pierre Lehn, Jean-Marie Lehn, Loïc Lemiègre, Thierry Benvegnu, Paul-Alain Jaffrès, Bruno Pitard, Tristan Montier

Publikováno v: Pharmaceutics, Vol 14, Iss 1, p 25 (2021)

Aerosol lung gene therapy using non-viral delivery systems represents a credible therapeutic strategy for chronic respiratory diseases, such as cystic fibrosis (CF). Progress in CF clinical setting using the lipidic formulation GL67A has demonstrated

Externí odkaz: https://doaj.org/article/3ac96a9742de4b9ca532dc89bdc93c79

Optimizations of In Vitro Mucus and Cell Culture Models to Better Predict In Vivo Gene Transfer in Pathological Lung Respiratory Airways: Cystic Fibrosis as an Example

Autor: Rosy Ghanem, Véronique Laurent, Philippe Roquefort, Tanguy Haute, Sophie Ramel, Tony Le Gall, Thierry Aubry, Tristan Montier

Publikováno v: Pharmaceutics, Vol 13, Iss 1, p 47 (2020)

The respiratory epithelium can be affected by many diseases that could be treated using aerosol gene therapy. Among these, cystic fibrosis (CF) is a lethal inherited disease characterized by airways complications, which determine the life expectancy

Externí odkaz: https://doaj.org/article/62383fc8d2bb413c99fc32e16440841b

Gene transfection using branched cationic amphiphilic compounds for an aerosol administration in cystic fibrosis context

Autor: Rosy, Ghanem, Mathieu, Berchel, Tanguy, Haute, Xavier, Buin, Véronique, Laurent, Raphaëlle, Youf, Amal, Bouraoui, Tony, Le Gall, Paul-Alain, Jaffrès, Tristan, Montier

Publikováno v: International Journal of Pharmaceutics. 631:122491

For cystic fibrosis gene therapy, the aerosolization of genetic materials is the most relevant delivery strategy to reach the airway epithelium. However, aerosolized formulations have to resist shear forces while maintaining the integrity of plasmid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda22cbdf6b352781488a59cab7dec0c
https://doi.org/10.1016/j.ijpharm.2022.122491

Substitution of unsaturated lipid chains by thioether-containing lipid chains in cationic amphiphiles: physicochemical consequences and application for gene delivery

Autor: Olivier Lozach, Mathieu Berchel, Tristan Montier, Laure Deschamps, Gilles Paboeuf, Rosy Ghanem, Véronique Vié, Tony Le Gall, Paul-Alain Jaffrès, Amal Bouraoui

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (14), pp.3609-3616. ⟨10.1039/c9ob00473d⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2019, 17 (14), pp.3609-3616. ⟨10.1039/c9ob00473d⟩

International audience; The hydrophobic moiety of cationic amphiphiles plays an important role in the transfection process because its structure has an impact on both the type of the supramolecular assembly and the dynamic properties of these assembl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a89f4b0f24bee6b66eee643b3ad4347
https://doi.org/10.1039/c9ob00473d