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Risk Factors for the Incidence of and the Mortality due to Post-Transplant Lymphoproliferative Disorder after Hematopoietic Cell Transplantation

Autor: Andrew Daly, Amit Kalra, Peter Duggan, Michelle Dowhan, Victor H Jimenez-Zepeda, Jan Storek, Megan Kinzel, Ahsan Chaudhry, Mona Shafey, Tyler Williamson, Faisal Khan, Poonam Dharmani-Khan, Rosy Dabas, Kareem Jamani

Publikováno v: Transplantation and cellular therapy. 28(1)

Post-transplant lymphoproliferative disorder (PTLD) is a potentially serious complication that occurs following hematopoietic cell transplantation (HCT), in which B cells transformed by Epstein-Barr virus (EBV) proliferate uncontrollably. It is unkno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f494b0ac90abc33878021e848501f20
https://pubmed.ncbi.nlm.nih.gov/34607072

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Antirelapse effect of pretransplant exposure to rabbit antithymocyte globulin

Autor: Douglas J. Mahoney, Samar Ousia, Kareem Jamani, Lynn Savoie, Caylib Durand, Don Morris, Shahbal B. Kangarloo, Victor H Jimenez-Zepeda, Andrew Daly, Faisal Khan, Rosy Dabas, Tyler Williamson, Ahsan Chaudhry, Jan Storek, Poonam Dharmani-Khan

Publikováno v: Blood Advances. 3:1394-1405

It remains unknown why rabbit antithymocyte globulin (ATG; Thymoglobulin) has not affected relapse after hematopoietic cell transplantation (HCT) in randomized studies. We hypothesized that high pre-HCT ATG area under the curve (AUC) would be associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97c456107835aaf85c34b2931d82ec9
https://doi.org/10.1182/bloodadvances.2018030247

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Rabbit Antithymocyte Globulin Serum Levels: Factors Impacting the Levels and Clinical Outcomes Impacted by the Levels

Autor: Poonam Dharmani-Khan, Joanne Luider, Faisal Khan, Andrew Daly, Jan Storek, Nicole L. Prokopishyn, Shahbal B. Kangarloo, Rosy Dabas, Kareem Jamani

Publikováno v: Biology of Blood and Marrow Transplantation. 25:639-647

Antithymocyte globulin (ATG) levels and clearance vary significantly among patients receiving the same weight-based dose of ATG. To date, ATG area under the curve (AUC), its determinants, and its impact on clinical outcomes have been examined in pedi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12e9dfa60baf2128601cf36caf6e1724
https://doi.org/10.1016/j.bbmt.2018.12.065

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High incidence of Pneumocystis jirovecii pneumonia in allogeneic hematopoietic cell transplant recipients in the modern era

Autor: Jennifer Jupp, Jan Storek, Peter Duggan, Michelle Dowhan, Victor H Jimenez-Zepeda, Christopher Evernden, Ahsan Chaudhry, Rosy Dabas, Poonam Dharmani-Khan, Daniel B. Gregson, Jason Tay, Faisal Khan, Andrew Daly, Kareem Jamani, Andrew Johnson, Amit Kalra

Publikováno v: Cytotherapy. 22(1)

International guidelines for Pneumocystis jirovecii pneumonia (PJP) prevention recommend prophylaxis for ≥6 months following allogeneic hematopoietic cell transplantation, and longer in patients with graft-versus-host disease (GVHD) or on immunosup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d8e569de37e4d2bf9bc83076c005c4
https://pubmed.ncbi.nlm.nih.gov/31889628

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More acute lymphoid leukemia than acute myeloid leukemia blasts are killed by rabbit antithymocyte globulin

Autor: Monica Modi, Poonam-Dharmani Khan, Rosy Dabas, Faisal Khan, Jan Storek

Publikováno v: Cytotherapy. 21(11)

Rabbit antithymocyte globulin (ATG, thymoglobulin), a polyclonal antibody, is used to prevent graft-versus-host disease (GVHD) and graft failure in the setting of allogeneic hematopoietic cell transplantation (HCT). Recent in vitro studies suggest th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad33173b48392ea5c9efaaae53ca4bf2
https://pubmed.ncbi.nlm.nih.gov/31543396

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Anti-thymocyte globulin's activity against acute myeloid leukemia stem cells

Autor: Joseph Brandwein, Rosy Dabas, Don Morris, Tiffany Van Slyke, Poonam Dharmani-Khan, Jan Storek, Monica Modi, Andrew Daly, Joanne Luider, Faisal Khan

Publikováno v: Bone marrow transplantation. 54(4)

Rabbit anti-thymocyte globulin (ATG (Thymoglobulin)) kills T cells in vitro and probably also in vivo as it prevents graft-vs-host disease (GvHD) in patients. Recently we demonstrated that ATG at a clinically relevant concentration (10–50 mg/L) kil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4e0ff57412e7b5e64a26306531437b
https://pubmed.ncbi.nlm.nih.gov/30108326

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High Pre-HCT Exposure to Thymoglobulin Is Associated with a Low Incidence of Relapse

Autor: Jan Storek, Douglas J. Mahoney, Rosy Dabas, Andrew Daly, Don Morris, Poonam Dharmani-Khan, Faisal Khan, Kareem Jamani, Bill Kangarloo

Publikováno v: Blood. 132:4605-4605

Introduction The most frequent serious complications of allogeneic hematopoietic cell transplant (HCT) are leukemia relapse and graft-vs-host disease (GVHD). Rabbit anti-T cell globulin (ATG, Thymoglobulin) reduces GVHD without increasing relapse, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ddd27b76b51697a231527a7d29dcf0b
https://doi.org/10.1182/blood-2018-99-117332

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