Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Roswitha Runge"'
Autor:
Lisa Hübinger, Kerstin Wetzig, Roswitha Runge, Holger Hartmann, Falk Tillner, Katja Tietze, Marc Pretze, David Kästner, Robert Freudenberg, Claudia Brogsitter, Jörg Kotzerke
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 534 (2024)
This work investigates the proposed enhanced efficacy of photodynamic therapy (PDT) by activating photosensitizers (PSs) with Cherenkov light (CL). The approaches of Yoon et al. to test the effect of CL with external radiation were taken up and refin
Externí odkaz:
https://doaj.org/article/5c71636248ab48eebfc37559bb75be19
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1720 (2023)
Background: The combination of platinum-containing cytostatic drugs with different radiation qualities has been studied for years. Despite their massive side effects, these drugs still belong to the therapeutic portfolio in cancer treatment. To overc
Externí odkaz:
https://doaj.org/article/5a8f05bb2a0d4c1d897a766a25194817
Autor:
Marc Pretze, Enrico Michler, Roswitha Runge, Kerstin Wetzig, Katja Tietze, Florian Brandt, Michael K. Schultz, Jörg Kotzerke
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1605 (2023)
(1) Background: In neuroendocrine tumors (NETs), somatostatin receptor subtype 2 is highly expressed, which can be targeted by a radioactive ligand such as [177Lu]Lu-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴,-tetraacetic acid-[Tyr3,Thr8]-octreo
Externí odkaz:
https://doaj.org/article/fc7267d8037448e8a88343f4e05e3afd
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 538 (2023)
Possibilities to improve the therapeutic efficacy of Lu-177–PSMA-617 radionuclide therapy by modulation of target expression are being investigated. Knowledge on regulatory factors that promote prostate cancer (PCa) progression may contribute to ta
Externí odkaz:
https://doaj.org/article/a62d6a64544046d3998ab6cdacdf68da
Autor:
Marc Pretze, Falk Kunkel, Roswitha Runge, Robert Freudenberg, Anja Braune, Holger Hartmann, Uwe Schwarz, Claudia Brogsitter, Jörg Kotzerke
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 652 (2021)
The application of 225Ac (half-life T1/2 = 9.92 d) dramatically reduces the activity used for peptide receptor radionuclide therapy by a factor of 1000 in comparison to 90Y, 177Lu or 188Re while maintaining the therapeutic outcome. Additionally, the
Externí odkaz:
https://doaj.org/article/9cc0c69b7c7547ec823b24ac1bd82ce7
Autor:
Marc Pretze, Valeska von Kiedrowski, Roswitha Runge, Robert Freudenberg, René Hübner, Güllü Davarci, Ralf Schirrmacher, Carmen Wängler, Björn Wängler
Publikováno v:
Nanomaterials, Vol 11, Iss 1, p 138 (2021)
This paper reports on the development of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via optical imaging (OI) before therapy is performed, being initiated via
Externí odkaz:
https://doaj.org/article/85f8866e199c45879cf6591866355639
Autor:
Joerg Kotzerke, Robert Punzet, Roswitha Runge, Sandra Ferl, Liane Oehme, Gerd Wunderlich, Robert Freudenberg
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104653 (2014)
(99m)Tc is the standard radionuclide used for nuclear medicine imaging. In addition to gamma irradiation, (99m)Tc emits low-energy Auger and conversion electrons that deposit their energy within nanometers of the decay site. To study the potential fo
Externí odkaz:
https://doaj.org/article/9f89f4e52bb24004960684750c66ab0a
Autor:
Lisa Hübinger, Roswitha Runge, Tobias Rosenberg, Robert Freudenberg, Jörg Kotzerke, Claudia Brogsitter
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15233
Possible enhancements of DNA damage with light of different wavelengths and ionizing radiation (Rhenium-188—a high energy beta emitter (Re-188)) on plasmid DNA and FaDu cells via psoralen were investigated. The biophysical experimental setup could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d066eacb35d4fa69b36bdc3b189fd00a
Autor:
Joerg Kotzerke, Dorothee Buesser, Anne Naumann, Roswitha Runge, Lisa Huebinger, Andrea Kliewer, Robert Freudenberg, Claudia Brogsitter
Publikováno v:
Cancers; Volume 14; Issue 10; Pages: 2513
The aim of the study was to increase the uptake of the SSTR2-targeted radioligand Lu-177-DOTATATE using the DNA methyltransferase inhibitor (DNMTi) 5-aza-2′-deoxycytidine (5-aza-dC) and the histone deacetylase inhibitor (HDACi) valproic acid (VPA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3c5df848cc120b0a7ed7fa326078ea
Autor:
Jörg Kotzerke, Roswitha Runge, Robert Freudenberg, Armin Lühr, Falco Reissig, Gerd Wunderlich
Publikováno v:
Nuclear Medicine and Biology. :65-70
Introduction Radiation-induced DNA damage occurs from direct and indirect effects. The induction is influenced by the physical characteristics of the radionuclide, especially its linear energy transfer. Hypoxia reduces the effect of irradiation treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42336841c3efec3a8c786f43c537bb6d
https://doi.org/10.1016/j.nucmedbio.2020.01.003
https://doi.org/10.1016/j.nucmedbio.2020.01.003