Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier.

Autor: Susan John, Lars Thiebach, Christian Frie, Sharada Mokkapati, Manuela Bechtel, Roswitha Nischt, Sally Rosser-Davies, Mats Paulsson, Neil Smyth

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34252 (2012)

Transglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization. Transglutaminase 1 is crucial in developing the epidermal barrier, however the ski

Externí odkaz: https://doaj.org/article/115f2202912843f0ba86fe4547dd8026

Dual role of laminin‑511 in regulating melanocyte migration and differentiation

Autor: Yasemin Üstün, Roswitha Nischt, Marion Reibetanz, Thomas Krieg, Beate Eckes, Paola Zigrino, Bent Brachvogel

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology. 80

Laminins are the major basement membrane (BM) components and are heterotrimers composed of an α, a β and a γ chain. In skin, laminins are present in basement membranes surrounding vascular structures, nerves, adipose tissue and in the specialized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d269a877a29e03a1f3772562ed9fd6
https://pubmed.ncbi.nlm.nih.gov/30273664

Anti-angiogenic effect of the basement membrane protein nidogen-1 in a mouse model of choroidal neovascularization

Autor: Norbert Kociok, Neil Smyth, Mats Paulsson, Irina Semkova, Dimitrios Karagiannis, Roswitha Nischt, Antonia M. Joussen, Olaf Strauß

Publikováno v: Experimental Eye Research. 118:80-88

In patients with age-related macular degeneration disruption of the integrity of the retinal pigment epithelium (RPE) and Bruch's membrane (BrM), precedes choroidal neovascularization (CNV). We investigated the role of the basement membrane (BM) prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65ef97dd2887c963c15b95b26c62869
https://doi.org/10.1016/j.exer.2013.11.006

Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis

Autor: Zu Lin Chen, Beate Eckes, Jeannine Wegner, Lydia Sorokin, Paola Zigrino, Lutz Langbein, Thomas Krieg, Anja Fleger-Weckmann, Ralf Paus, Roswitha Nischt, Yasemin Üstün, Wilhelm Bloch, Jennifer E. Kloepper

Publikováno v: Fleger-Weckmann, A, Üstün, Y, Kloepper, J, Paus, R, Bloch, W, Chen, Z L, Wegner, J, Sorokin, L, Langbein, L, Eckes, B, Zigrino, P, Krieg, T & Nischt, R 2016, ' Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis ', Matrix Biology . https://doi.org/10.1016/j.matbio.2016.05.002

Laminins are the most abundant non-collagenous basement membrane (BM) components, composed of an α, β and γ chain. The laminin γ1 chain, encoded by LAMC1, is the most abundant γ chain. The main laminin isoforms in the dermo-epidermal junction (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc892041a500bb4eb2dde5ebb22aee8e
https://pubmed.ncbi.nlm.nih.gov/27234308

Different domains in nidogen‐1 and nidogen‐2 drive basement membrane formation in skin organotypic cocultures

Autor: Wilhelm Bloch, Petra Boukamp, Roswitha Nischt, Takako Sasaki, Manuel V. Keller, Mats Paulsson, Frank Zaucke, Manuela Bechtel

Publikováno v: The FASEB Journal. 26:3637-3648

Nidogen-1 and nidogen-2 are homologous proteins found in all basement membranes (BMs). They show comparable binding activities in vitro and partially redundant functions in vivo. Previously, we showed that in skin organotypic cocultures, BM formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cdfb63b94885e54802471a9dc161e5
https://doi.org/10.1096/fj.11-194597