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pro vyhledávání: '"Rostron AJ"'
Akademický článek
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Autor:
Widdrington, JD, Gomez-Duran, A, Steyn, JS, Pyle, A, Ruchaud-Sparagano, M-H, Scott, J, Baudouin, SV, Rostron, AJ, Simpson, J, Chinnery FMedSci, PF
Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03274b52a3e6bafd1b4e916d8eae7f5b
Akademický článek
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Akademický článek
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Autor:
Thompson JH; Integrated Critical Care Unit, Sunderland Royal Hospital, Sunderland, UK; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. Electronic address: jack.thompson@ncl.ac.uk., Reddy K; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Matthay MA; Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA; Department of Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., McAuley DF; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Simpson AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; Respiratory Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Rostron AJ; Integrated Critical Care Unit, Sunderland Royal Hospital, Sunderland, UK; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Publikováno v:
British journal of anaesthesia [Br J Anaesth] 2024 Sep; Vol. 133 (3), pp. 700-703. Date of Electronic Publication: 2024 Jul 16.
Autor:
Brooks D; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK; Emergency Department, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia., Wright SE; Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle Upon Tyne NE7 7DN, UK., Beattie A; Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne NE7 7DN, UK., McAllister N; Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle Upon Tyne NE7 7DN, UK., Anderson NH; Usher Institute, University of Edinburgh, Old Medial School, Teviot Place, Edinburgh EH8 9AG, UK., Roy AI; Integrated Critical Care Unit, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK., Gonsalves P; Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne NE7 7DN, UK., Yates B; Critical Care Unit, Northumbria Specialist Emergency Care Hospital, Northumbria Way, Cramlington NE23 6NZ, UK., Graziadio S; NIHR Newcastle In Vitro Diagnostics Co-operative, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; York Health Economics Consortium, University of York, York YO10 5NQ, UK., Mackie A; Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne NE7 7DN, UK., Davidson J; Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle Upon Tyne NE7 7DN, UK., Gopal SV; Department of Radiology, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK., Whittle R; Critical Care Unit, Northumbria Specialist Emergency Care Hospital, Northumbria Way, Cramlington NE23 6NZ, UK., Zahed A; Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne NE7 7DN, UK., Barton L; Critical Care Unit, Northumbria Specialist Emergency Care Hospital, Northumbria Way, Cramlington NE23 6NZ, UK., Elameer M; Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne NE7 7DN, UK., Tuckett J; Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne NE7 7DN, UK., Holmes R; Department of Radiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne NE7 7DN, UK., Sutcliffe A; Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle Upon Tyne NE7 7DN, UK., Santamaria N; Department of Radiology, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK; Department of Radiology, Clatterbridge Cancer Centre, l, Liverpool L7 8YA, UK., de Lalouviere LH; Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle Upon Tyne NE7 7DN, UK., Gupta S; Department of Radiology, Northumbria Specialist Emergency Care Hospital, Northumbria Way, Cramlington NE23 6NZ, UK., Subramaniam J; Critical Care Unit, Northumbria Specialist Emergency Care Hospital, Northumbria Way, Cramlington NE23 6NZ, UK., Pearson JA; Integrated Critical Care Unit, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK; Intensive Care Unit, James Cook University Hospital, Middlesbrough TS4 3BW, UK., Brandwood M; Integrated Critical Care Unit, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK., Burnham R; Critical Care Unit, Northumbria Specialist Emergency Care Hospital, Northumbria Way, Cramlington NE23 6NZ, UK., Rostron AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK; Integrated Critical Care Unit, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK., Simpson AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK; NIHR Newcastle In Vitro Diagnostics Co-operative, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Respiratory Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK. Electronic address: j.simpson@ncl.ac.uk.
Publikováno v:
Journal of critical care [J Crit Care] 2024 Aug; Vol. 82, pp. 154760. Date of Electronic Publication: 2024 Mar 15.
Autor:
Martin DS; Peninsula Medical School, University of Plymouth, Plymouth, UK.; Intensive Care Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK., Shahid T; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., Gould DW; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., Richards-Belle A; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., Doidge JC; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., Camsooksai J; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., Charles WN; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., Davey M; Critical Care, Maidstone and Tunbridge Wells NHS Foundation Trust, Kent, UK., Francis Johnson A; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., Garrett RM; Patient and Public Representative, Bristol, UK., Grocott MP; Perioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, UK., Jones J; Critical Care, Maidstone and Tunbridge Wells NHS Foundation Trust, Kent, UK., Lampro L; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., Miller L; Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), Napier House, London, UK., O'Driscoll BR; Respiratory Medicine, Northern Care Alliance NHS Foundation Trust, Salford Royal University Hospital, Salford, UK., Rostron AJ; Integrated Critical Care Unit, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK., Sadique Z; Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK., Szakmany T; Critical Care, Aneurin Bevan University Health Board, Cwmbran, UK., Young PJ; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.; Medical Research Institute of New Zealand, Wellington, New Zealand.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia., Rowan KM; Intensive Care Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK., Harrison DA; Intensive Care Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK., Mouncey PR; Intensive Care Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Publikováno v:
Journal of the Intensive Care Society [J Intensive Care Soc] 2024 Apr 11; Vol. 25 (2), pp. 223-230. Date of Electronic Publication: 2024 Apr 11 (Print Publication: 2024).
Autor:
Silversides JA; Department of Critical Care, Belfast Health and Social Care Trust, Belfast, UK. j.silversides@qub.ac.uk.; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University of Belfast, Lisburn Road, Belfast, BT9 7BL, UK. j.silversides@qub.ac.uk., McMullan R; Department of Critical Care, Belfast Health and Social Care Trust, Belfast, UK., Emerson LM; School of Health Sciences, City, University of London, London, UK., Bradbury I; Independent Consulting Statistician, Aviemore, UK., Bannard-Smith J; Department of Critical Care, Manchester University NHS Foundation Trust, Manchester, UK.; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK., Szakmany T; Critical Care Directorate, Aneurin Bevan University Health Board, Newport, UK.; Department of Anaesthesia, Intensive Care and Pain Medicine, Cardiff University, Cardiff, UK., Trinder J; Intensive Care Unit, South-Eastern Health and Social Care Trust, Dundonald, UK., Rostron AJ; Integrated Critical Care Unit, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Johnston P; Intensive Care Unit, Northern Health and Social Care Trust, Antrim, UK., Ferguson AJ; Department of Critical Care, Belfast Health and Social Care Trust, Belfast, UK., Boyle AJ; Department of Critical Care, Belfast Health and Social Care Trust, Belfast, UK.; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University of Belfast, Lisburn Road, Belfast, BT9 7BL, UK.; Intensive Care Unit, Northern Health and Social Care Trust, Antrim, UK., Blackwood B; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University of Belfast, Lisburn Road, Belfast, BT9 7BL, UK., Marshall JC; Keenan Research Centre for Biomedical Science, Unity Health Toronto, Toronto, Canada.; Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada., McAuley DF; Department of Critical Care, Belfast Health and Social Care Trust, Belfast, UK.; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University of Belfast, Lisburn Road, Belfast, BT9 7BL, UK.
Publikováno v:
Intensive care medicine [Intensive Care Med] 2023 Nov; Vol. 49 (11), pp. 1440.
Autor:
Powell J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK jason.powell@doctors.org.uk.; Department of Paediatric Otolaryngology, Great North Children's Hospital, Newcastle upon Tyne, UK., Powell S; Department of Paediatric Otolaryngology, Great North Children's Hospital, Newcastle upon Tyne, UK., Mather MW; Department of Paediatric Otolaryngology, Great North Children's Hospital, Newcastle upon Tyne, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Beck L; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Nelson A; Department of Applied Science, Northumbria University, Newcastle upon Tyne, UK., Palmowski P; Protein and Proteome Facility, Newcastle University, Newcastle upon Tyne, UK., Porter A; Protein and Proteome Facility, Newcastle University, Newcastle upon Tyne, UK., Coxhead J; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Hedley A; Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, UK., Scott J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Rostron AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Hellyer TP; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Zaidi F; Discovery and Translational Science, Metabolon, Morrisville, North Carolina, USA., Davey T; Electron Microscopy Research Services, Newcastle University, Newcastle upon Tyne, UK., Garnett JP; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Agbeko R; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Paediatric Intensive Care, Great North Children's Hospital, Newcastle upon Tyne, UK., Ward C; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Stewart CJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Taggart CC; Experimental Medicine, Queen's University Belfast, Belfast, UK., Brodlie M; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne, UK., Simpson AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Publikováno v:
Thorax [Thorax] 2023 Oct; Vol. 78 (10), pp. 1019-1027. Date of Electronic Publication: 2023 Feb 20.