Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Rostislav Vecera"'
Autor:
Rostislav Vecera, Martin Poruba, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Zuzana Racova, Jan Soukop, Ludmila Kazdova
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 5, Pp 1889-1900 (2022)
The efficacy of fenofibrate in the treatment of hepatic steatosis has not been clearly demonstrated. In this study, we investigated the effects of fenofibrate and silymarin, administered as monotherapy and in combination to existing hepatic steatosis
Externí odkaz:
https://doaj.org/article/b82668e3dd6848b6afbb2ca9d5af9fdc
Autor:
Martina Hüttl, Irena Markova, Denisa Miklankova, Iveta Zapletalova, Martin Poruba, Zuzana Racova, Rostislav Vecera, Hana Malinska
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 45 (2021)
The combination of plant-derived compounds with anti-diabetic agents to manage hepatic steatosis closely associated with diabetes mellitus may be a new therapeutic approach. Silymarin, a complex of bioactive substances extracted from Silybum marianum
Externí odkaz:
https://doaj.org/article/8958765974644291a660f42016709d97
Autor:
Martin Poruba, Zuzana Matuskova, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Sona Gurska, Ludmila Kazdova, Rostislav Vecera
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
P-glycoprotein (P-gp) is a membrane-bound transporter encoded by Mdr1a/Abcb1a and Mdr1b/Abcb1b genes in rodents involved in the efflux of cytotoxic chemicals and metabolites from cells. Modulation of its activity influences P-gp-mediated drug deliver
Externí odkaz:
https://doaj.org/article/113954a4a033452dbb722890110db9d1
Autor:
Hana Malinska, Martina Hüttl, Olena Oliyarnyk, Irena Markova, Martin Poruba, Zuzana Racova, Ludmila Kazdova, Rostislav Vecera
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220377 (2019)
BackgroundTroxerutin (TRX) has a beneficial effect on blood viscosity and platelet aggregation, and is currently used for the treatment of chronic varicosity. Recently, TRX can improve lipid abnormalities, glucose intolerance and oxidative stress in
Externí odkaz:
https://doaj.org/article/71daab0ab7594bec8c1d6c1d56e3c3c3
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191041 (2018)
Sensors able to record large bowel physiology and biochemistry in situ in awake rodents are lacking. Microdialysis is a mini-invasive technique that may be utilized to continuously deliver or recover low-molecular substances from various tissues. In
Externí odkaz:
https://doaj.org/article/555b99b2c9694e42bbb89e7d67685bcb
Autor:
Zuzana Matuskova, Eva Anzenbacherova, Rostislav Vecera, Helena Tlaskalova-Hogenova, Milan Kolar, Pavel Anzenbacher
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87150 (2014)
The growing interest in the composition and effects of microbiota raised the question how drug pharmacokinetics could be influenced by concomitant application of probiotics. The aim of this study was to find whether probiotic E. coli strain Nissle 19
Externí odkaz:
https://doaj.org/article/a6b72c2832554f9ba7d96d0c289a092f
Autor:
Hana Kozakova, Tomas Hudcovic, Milan Kolar, Eva Anzenbacherova, Petra Hermanova, Lenka Jourova, Jan Strojil, Zuzana Matuskova, Miloslav Kverka, Pavel Anzenbacher, Rostislav Vecera, Milan Nobilis
Publikováno v:
Xenobiotica. 49:1296-1302
1. The underlying microbial metabolic activity toward xenobiotics is among the least explored factors contributing to the inter-individual variability in drug response. 2. Here, we analyzed the effect of microbiota on a non-steroidal anti-inflammator
Autor:
Lenka, Jourova, Pavel, Anzenbacher, Zuzana, Matuskova, Rostislav, Vecera, Jan, Strojil, Milan, Kolar, Milan, Nobilis, Petra, Hermanova, Tomas, Hudcovic, Hana, Kozakova, Miloslav, Kverka, Eva, Anzenbacherova
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 49(11)
1. The underlying microbial metabolic activity toward xenobiotics is among the least explored factors contributing to the inter-individual variability in drug response. 2. Here, we analyzed the effect of microbiota on a non-steroidal anti-inflammator
Autor:
Zuzana Racova, Martin Poruba, Irena Markova, Ludmila Kazdova, Hana Malinska, Rostislav Vecera, Olena Oliyarnyk, Martina Hüttl
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0220377 (2019)
PLoS ONE, Vol 14, Iss 8, p e0220377 (2019)
BackgroundTroxerutin (TRX) has a beneficial effect on blood viscosity and platelet aggregation, and is currently used for the treatment of chronic varicosity. Recently, TRX can improve lipid abnormalities, glucose intolerance and oxidative stress in
Autor:
Zuzana Matuskova, Pavel Anzenbacher, Helena Tlaskalova-Hogenova, Rostislav Vecera, Michal Siller, Jan Strojil, Eva Anzenbacherova
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 42:29-36
The probiotic bacterium Escherichia coli strain Nissle 1917 has previously been shown to alter the pharmacokinetics of amiodarone. The aim of this study was to determine whether the probiotic bacterium Lactobacillus casei produces similar alterations