Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Rostislav Bychkov"'
Autor:
Kirill V Tarasov, Khalid Chakir, Daniel R Riordon, Alexey E Lyashkov, Ismayil Ahmet, Maria Grazia Perino, Allwin Jennifa Silvester, Jing Zhang, Mingyi Wang, Yevgeniya O Lukyanenko, Jia-Hua Qu, Miguel Calvo-Rubio Barrera, Magdalena Juhaszova, Yelena S Tarasova, Bruce Ziman, Richard Telljohann, Vikas Kumar, Mark Ranek, John Lammons, Rostislav Bychkov, Rafael de Cabo, Seungho Jun, Gizem Keceli, Ashish Gupta, Dongmei Yang, Miguel A Aon, Luigi Adamo, Christopher H Morrell, Walter Otu, Cameron Carroll, Shane Chambers, Nazareno Paolocci, Thanh Huynh, Karel Pacak, Robert Weiss, Loren Field, Steven J Sollott, Edward G Lakatta
Publikováno v:
eLife, Vol 11 (2022)
Adult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TGAC8) adapt to an increased cAMP-induced cardiac workload (~30% increases in heart rate, ejection fraction and cardiac output) for up to a year without sig
Externí odkaz:
https://doaj.org/article/14634285f8224aeeb9edfd895e31e4f8
Autor:
Kenta Tsutsui, Maria Cristina Florio, Annie Yang, Ashley N. Wirth, Dongmei Yang, Mary S. Kim, Bruce D. Ziman, Rostislav Bychkov, Oliver J. Monfredi, Victor A. Maltsev, Edward G. Lakatta
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Action potential (AP) firing rate and rhythm of sinoatrial nodal cells (SANC) are controlled by synergy between intracellular rhythmic local Ca2+ releases (LCRs) (“Ca2+ clock”) and sarcolemmal electrogenic mechanisms (“membrane clock”). Howev
Externí odkaz:
https://doaj.org/article/517a997c43364d4b8d151adc3f767964
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75077 (2013)
We tested the hypothesis that protein kinase A (PKA) inhibits K2P currents activated by protein kinase C (PKC) in freshly isolated aortic myocytes. PDBu, the PKC agonist, applied extracellularly, increased the amplitude of the K2P currents in the pre
Externí odkaz:
https://doaj.org/article/accfd8d513a5432f8c3cf08247edf73e
Autor:
Rostislav Bychkov, Magdalena Juhaszova, Miguel Calvo-Rubio Barrera, Lorenzo A.H. Donald, Christopher Coletta, Chad Shumaker, Kayla Moorman, Syevda Tagirova Sirenko, Alexander V. Maltsev, Steven J. Sollott, Edward G. Lakatta
Publikováno v:
JACC: Clinical Electrophysiology. 8:1191-1215
Autor:
Kirill V Tarasov, Khalid Chakir, Daniel R Riordon, Alexey E Lyashkov, Ismayil Ahmet, Maria Grazia Perino, Allwin Jennifa Silvester, Jing Zhang, Mingyi Wang, Yevgeniya O Lukyanenko, Jia-Hua Qu, Miguel Calvo-Rubio Barrera, Magdalena Juhaszova, Yelena S Tarasova, Bruce Ziman, Richard Telljohann, Vikas Kumar, Mark Ranek, John Lammons, Rostislav Bychkov, Rafael de Cabo, Seungho Jun, Gizem Keceli, Ashish Gupta, Dongmei Yang, Miguel A Aon, Luigi Adamo, Christopher H Morrell, Walter Otu, Cameron Carroll, Shane Chambers, Nazareno Paolocci, Thanh Huynh, Karel Pacak, Robert Weiss, Loren Field, Steven J Sollott, Edward G Lakatta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1894a8ea0d2bfaa8df43234a7e7771be
https://doi.org/10.7554/elife.80949.sa2
https://doi.org/10.7554/elife.80949.sa2
Autor:
Rostislav Bychkov, Magdalena Juhaszova, Miguel Calvo-Rubio Barrera, Lorenzo A.H. Donald, Christopher Coletta, Chad Shumaker, Kayla Moorman, Syevda Tagirova, Alexander V. Maltsev, Steven J. Sollott, Edward G. Lakatta
Publikováno v:
Biophysical Journal. 122:233a
Autor:
Rostislav Bychkov, Magdalena Juhaszova, Miguel Calvo-Rubio, Lorenzo A. H. Donald, Chris Coletta, Chad Shumaker, Kayla Moorman, Syevda Tagirova Sirenko, Alex V. Maltsev, Steven J. Sollott, Edward G. Lakatta
ObjectivesThis study sought to describe the 3D cytoarchitecture of sinoatrial node tissue, including autonomic innervation, peripheral glial cells, and pacemaker cells.BackgroundThe sinoatrial node of the heart produces rhythmic action potentials (AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::109031a3187d4d77444b6d8550d59663
https://doi.org/10.1101/2022.02.04.478900
https://doi.org/10.1101/2022.02.04.478900
Autor:
Victor A. Maltsev, Magdalena Juhaszova, Michael D. Stern, Kenta Tsutsui, Rostislav Bychkov, Edward G. Lakatta, Christopher E. Coletta
Publikováno v:
JACC: Clinical Electrophysiology. 6:907-931
Objectives This study sought to identify subcellular Ca2+ signals within and among cells comprising the sinoatrial node (SAN) tissue. Background The current paradigm of SAN impulse generation: 1) is that full-scale action potentials (APs) of a common
Autor:
Magdalena Juhaszova, Victor A. Maltsev, Edward G. Lakatta, Christopher E. Coletta, Rostislav Bychkov, Michael D. Stern, Kenta Tsutsui
BackgroundThe current paradigm of Sinoatrial Node (SAN) impulse generation: (i) is that full-scale action potentials (APs) of a common frequency are initiated at one site and are conducted within the SAN along smooth isochrones; and (ii) does not fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8d9cf986a10a233043ecbacd3a055e
https://doi.org/10.1101/2020.04.14.039461
https://doi.org/10.1101/2020.04.14.039461
Autor:
Edward G. Lakatta, Harold A. Spurgeon, Victor A. Maltsev, Daniel Yaeger, Syevda Sirenko, Tatiana M. Vinogradova, Rostislav Bychkov, Yael Yaniv
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 311:H251-H267
Coupling of an intracellular Ca2+ clock to surface membrane ion channels, i.e., a “membrane clock, ” via coupling of electrochemical Na+ and Ca2+ gradients ( ENa and ECa, respectively) has been theorized to regulate sinoatrial nodal cell (SANC) n