Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rostislav A. Petrov"'
Autor:
Igor D. Zlotnikov, Alexander A. Ezhov, Rostislav A. Petrov, Maksim A. Vigovskiy, Olga A. Grigorieva, Natalya G. Belogurova, Elena V. Kudryashova
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1172 (2022)
Bacterial infections and especially resistant strains of pathogens localized in macrophages and granulomas are intractable diseases that pose a threat to millions of people. In this paper, the theoretical and experimental foundations for solving this
Externí odkaz:
https://doaj.org/article/acf8ff5ff2d84ff4af5e7430b526ff08
Autor:
Stanislav A. Petrov, Aleksei E. Machulkin, Anastasia A. Uspenskaya, Nikolay Y. Zyk, Ekaterina A. Nimenko, Anastasia S. Garanina, Rostislav A. Petrov, Vladimir I. Polshakov, Yuri K. Grishin, Vitaly A. Roznyatovsky, Nikolay V. Zyk, Alexander G. Majouga, Elena K. Beloglazkina
Publikováno v:
Molecules, Vol 25, Iss 24, p 5784 (2020)
A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) receptor was developed. The proposed platform contains a urea-based, PS
Externí odkaz:
https://doaj.org/article/ae00a4fa5629496f8c958afc95c1484f
Autor:
Vladimir A. Aladinskiy, Rostislav A Petrov, Yan A. Ivanenkov, Mark S. Veselov, Andrey A Ayginin, Alexey Kh Baimiev, Maria M Puchinina, Marina A Maximova, Anastasia V. Aladinskaya, Dmitry A. Skvortsov, Kseniya Yu Shvetc, Yulia V. Vakhitova, Alina A. Sofronova, Ilya A. Osterman, Andrey Kh Baimiev, Zulfiya R Zileeva, Katerina S Komarova, Dmitry S. Bezrukov, L. F. Zainullina, Victor A Terentiev, Bogdan A Zagribelnyy, Petr V. Sergiev, Alexey E. Machulkin, Renat S. Yamidanov, Olga A. Dontsova
Publikováno v:
Current Drug Discovery Technologies. 17:716-724
Background: The key issue in the development of novel antimicrobials is a rapid expansion of new bacterial strains resistant to current antibiotics. Indeed, World Health Organization has reported that bacteria commonly causing infections in hospitals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a9cc3c7142a75575f2c9fc022e9cc1
https://doi.org/10.2174/1570163816666190603095521
https://doi.org/10.2174/1570163816666190603095521
Publikováno v:
BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES. :158-160
The conjugates of paclitaxel and betulin with N-acetylgalactosamine were obtained, their affinity to the asialoglycoprotein receptor was evaluated via surface plasmon resonance spectroscopy technique. Thermodynamic dissociation constants (KD) were de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3d715f3805c0a491439803547b6dd2
https://doi.org/10.37747/2312-640x-2020-18-158-160
https://doi.org/10.37747/2312-640x-2020-18-158-160
Autor:
Ya. A. Ivanenkov, Sergey V. Kovalev, Elena K. Beloglazkina, E. Yu. Yamansarov, Natalia L. Klyachko, Nikolai V. Zyk, Rostislav A Petrov, Dmitry A. Skvortsov, Sergei A Evteev, Anton V Lopukhov, Alexander G. Majouga
Publikováno v:
Russian Chemical Bulletin. 68:2331-2338
New ligands for targeted delivery to the liver based on glycoconjugated natural triterpenoids are proposed. Simple chemical transformations of starting lupane triterpenes led to betulin or betulinic acid conjugates with N-acetyl-d-galactosamine linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e6f153ec852abc74a9c23a071b5973f
https://doi.org/10.1007/s11172-019-2707-9
https://doi.org/10.1007/s11172-019-2707-9
Autor:
Rostislav A Petrov, Dmitry A. Skvortsov, Yulia V. Vakhitova, L. F. Zainullina, Andrey A Ayginin, Yan A. Ivanenkov, Marina A Maximova, Mark S. Veselov, Alina A. Sofronova, Petr V. Sergiev, G. I. Filkov, Alexey E. Machulkin, Katerina S Komarova, Anastasia V. Aladinskaya, Renat S. Yamidanov, Victor A Terentiev, Olga A. Dontsova, Alexander S. Malyshev, Alexey Kh Baimiev, Maria M Puchinina, Ilya A. Osterman, Dmitry S. Bezrukov, A. V. Chemeris, Zulfiya R Zileeva, Vladimir A. Aladinskiy
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 22:346-354
Aim and Objective:Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336c3c036716b074c805801cbd19401f
https://doi.org/10.2174/1386207322666190412165316
https://doi.org/10.2174/1386207322666190412165316
Autor:
Andrey Baymiev, Rostislav A Petrov, Svetlana Iu Iarovenko, Vladimir A. Aladinskiy, Renat S. Yamidanov, Alexey E. Machulkin, Yan A. Ivanenkov, Mark S. Veselov, Katerina S Komarova, Olga A. Dontsova, Alexander S. Malyshev, Anastasia V. Aladinskaya, Victor A Terentiev, Andrey A Ayginin, Alina A. Sofronova, Petr V. Sergiev, Dmitry A. Skvortsov, Sergey V. Sadovnikov, Dmitrii A. Lukianov, Ilya A. Osterman, Dmitry S. Bezrukov, R.T. Matniyazov
Publikováno v:
The Journal of Antibiotics. 72:827-833
The present report describes our efforts to identify new structural classes of compounds having promising antibacterial activity using previously published double-reporter system pDualrep2. This semi-automated high-throughput screening (HTS) platform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a36fba2b0d31d2a9e5211cc1d0ef53e
https://doi.org/10.1038/s41429-019-0211-y
https://doi.org/10.1038/s41429-019-0211-y
Autor:
Irina V. Saltykova, E. Yu. Yamansarov, E. I. Seleznev, Alexander G. Majouga, Sergey V. Kovalev, Elena K. Beloglazkina, Rostislav A Petrov, Dmitry O Shkil
Publikováno v:
Russian Chemical Bulletin. 68:855-861
Pentacyclic triterpene hydroxy acids were transformed into acetylene-containing derivatives: propargyl esters at the carboxy group and O-(hex-5-ynoyl) derivatives at the hydroxy group. The cytotoxicity of the synthesized compounds was examined agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd1a779032187875f726befc1c8df42b
https://doi.org/10.1007/s11172-019-2496-1
https://doi.org/10.1007/s11172-019-2496-1
Autor:
Olga Y. Burenina, Dmitrii A Grishin, Yan A. Ivanenkov, Sergey V. Kovalev, Yury V. Timchenko, Alexander Vaneev, Svetlana Yu. Maklakova, Alexander G. Majouga, Natalia L. Klyachko, Rostislav A Petrov, Alexander Erofeev, Elena K. Beloglazkina, Emil Yu. Yamansarov, Roman Timoshenko, Petr V. Gorelkin, Elena V Lopatukhina, Evgenia E Ondar, Sergei A Evteev, Anton V Lopukhov, Sofiia R Mefedova
Publikováno v:
Molecular pharmaceutics. 18(1)
In this work, we have developed covalent and low molecular weight docetaxel delivery systems based on conjugation with N-acetyl-d-galactosamine and studied their properties related to hepatocellular carcinoma cells. The resulting glycoconjugates have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e137e7aecf403164e00f990463563d82
https://pubmed.ncbi.nlm.nih.gov/33264010
https://pubmed.ncbi.nlm.nih.gov/33264010
Autor:
Nikolay V. Zyk, Anastasia S. Garanina, Anastasia A. Uspenskaya, Yuri K. Grishin, Aleksei E. Machulkin, Vladimir I. Polshakov, Ekaterina A. Nimenko, Rostislav A Petrov, Nikolay Y. Zyk, Vitaly A. Roznyatovsky, Stanislav A. Petrov, Elena K. Beloglazkina, Alexander G. Majouga
Publikováno v:
Molecules, Vol 25, Iss 5784, p 5784 (2020)
Molecules
Volume 25
Issue 24
Molecules
Volume 25
Issue 24
A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) receptor was developed. The proposed platform contains a urea-based, PS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e065d108521f08232fbbde0a416c3af
https://www.mdpi.com/1420-3049/25/24/5784
https://www.mdpi.com/1420-3049/25/24/5784