Bioactivity Signatures of Drugs vs. Environmental Chemicals Revealed by Tox21 High-Throughput Screening Assays

Autor: Deborah K. Ngan, Lin Ye, Leihong Wu, Menghang Xia, Anna Rossoshek, Anton Simeonov, Ruili Huang

Publikováno v: Frontiers in Big Data, Vol 2 (2019)

Humans are exposed to tens of thousands of chemicals over the course of a lifetime, yet there remains inadequate data on the potential harmful effects of these substances on human health. Using quantitative high-throughput screening (qHTS), we can te

Externí odkaz: https://doaj.org/article/fea813c6ece04f3cb4d4322466518265

Tox21Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Chemicals and Drugs

Autor: Ruili Huang, Menghang Xia, Dac-Trung Nguyen, Tongan Zhao, Srilatha Sakamuru, Jinghua Zhao, Sampada A. Shahane, Anna Rossoshek, Anton Simeonov

Publikováno v: Frontiers in Environmental Science, Vol 3 (2016)
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs

Tens of thousands of chemicals with poorly understood biological properties are released into the environment each day. High-throughput screening (HTS) is potentially a more efficient and cost-effective alternative to traditional toxicity tests. Usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf1eb571b0bedb0e365dd34817d83c2

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Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain.

Autor: Cronin, Kenneth D., Ge, Dongliang, Manninger, Paul, Linnertz, Colton, Rossoshek, Anna, Orrison, Bonnie M., Bernard, David J., El-Agnaf, Omar M.A., Schlossmacher, Michael G., Nussbaum, Robert L., Chiba-Falek, Ornit

Publikováno v: Human Molecular Genetics; Sep2009, Vol. 18 Issue 17, p3274-3285, 12p