Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rossman Pamela Loreen"'
Autor:
Peter Michael Wovkulich, Cheryl Janson, Hongmao Sun, Yang He, Rossman Pamela Loreen, Qing Xiang, Xiaolei Zhang, Zhi Chen, Qi Qiao, Romyr Dominique, Christine Lukacs, Kin-Chun Luk, Yi Chen, Kevin W. Anderson, Aruna Railkar, Kelli Glenn, Ann Polonskaia, Masha Vilenchik
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6610-6615
DYRK1B is a kinase over-expressed in certain cancer cells (including colon, ovarian, pancreatic, etc.). Recent publications have demonstrated inhibition of DYRK1B could be an attractive target for cancer therapy. From a data-mining effort, the team h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc5019acedd92e1f83d6b4a4d17562a
https://doi.org/10.1016/j.bmcl.2013.10.055
https://doi.org/10.1016/j.bmcl.2013.10.055
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:209-214
The synthesis and antibacterial activity of a novel ‘tetrazole-tethered’ cephalosporin-quinolone hybrid is described. The in vitro spectrum of 7 mirrored that of a third-generation cephalosporin. Quinolone-like activity was not observed. β-Lacta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c30f36ebc785111f39a38f7f55adff4d
https://doi.org/10.1016/s0960-894x(01)80878-7
https://doi.org/10.1016/s0960-894x(01)80878-7
Autor:
Harry Allen Albrecht, Dennis D. Keith, J. G. Christenson, Chung-Chen Wei, Konzelmann Frederick Martin, N H Georgopapadakou, G. Beskid, Rossman Pamela Loreen, David L. Pruess
Publikováno v:
ChemInform. 23
A series of cephalosporins has been prepared in which the 3'-position was linked to the nitrogen of the antibacterial quinolone ciprofloxacin through a carbamate function. Like the ester-linked and quaternary-linked dual-action cephalosporins reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0404f52cb9aaa5b3848528cd96288098
https://doi.org/10.1002/chin.199210294
https://doi.org/10.1002/chin.199210294
Publikováno v:
ChemInform. 24
The synthesis and antibacterial activity of a novel ‘tetrazole-tethered’ cephalosporin-quinolone hybrid is described. The in vitro spectrum of 7 mirrored that of a third-generation cephalosporin. Quinolone-like activity was not observed. β-Lacta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aeb5e3e48511d4297be8f484c12ef13
https://doi.org/10.1002/chin.199332273
https://doi.org/10.1002/chin.199332273
Autor:
Hong Yang, Irena Daniewski, Dorota Miklowski, Brian Higgins, Giacomo Pizzolato, Fred Konzelmann, Christine Lukacs, Peter Michael Wovkulich, Rossman Pamela Loreen, Kenneth Kolinsky, Xuefeng Yin, Wei Chung-Chen, Grace Ju, Qingjie Ding, Kshitij Chhabilbhai Thakkar, Amy Swain, Jin-Jun Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(20)
A novel series of pyrazolobenzodiazepines 3 has been identified as potent inhibitors of cyclin-dependent kinase 2 (CDK2). Their synthesis and structure-activity relationships (SAR) are described. Representative compounds from this class reversibly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3779ce22a7db6be82920da5853d825bf
https://pubmed.ncbi.nlm.nih.gov/20832307
https://pubmed.ncbi.nlm.nih.gov/20832307
Autor:
David L. Pruess, Konzelmann Frederick Martin, Dennis D. Keith, Harry Allen Albrecht, Rossman Pamela Loreen, Chung-Chen Wei, J. G. Christenson, N H Georgopapadakou, G. Beskid
Publikováno v:
Journal of Medicinal Chemistry. 34:2857-2864
A series of cephalosporins has been prepared in which the 3'-position was linked to the nitrogen of the antibacterial quinolone ciprofloxacin through a carbamate function. Like the ester-linked and quaternary-linked dual-action cephalosporins reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a185190306e5c42f1b249828d56288
https://doi.org/10.1021/jm00113a026
https://doi.org/10.1021/jm00113a026
Autor:
E. R. Lipschitz, D. H. Mcgarry, Dennis D. Keith, G. Beskid, V. Fallot, Rossman Pamela Loreen, Jo Ann Siebelist, Carolyn M. McGarry, Harry Allen Albrecht
Publikováno v:
Chemotherapy. 37:310-317
Ro 24-4383 contains desacetylcefotaxime linked by a carbamate bond at the 3' position to ciprofloxacin. Ro 24-4383 was active against 99% of the 363 gram-positive and gram-negative aerobes tested in vitro, while the comparative agents cefotaxime and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7995df162a7f18a2e9e71fc12114952a
https://doi.org/10.1159/000238873
https://doi.org/10.1159/000238873
Autor:
Chung-Chen Wei, Roxana Yang, John Lawson Roberts, D.W. Moore, Rossman Pamela Loreen, T. Steppe, Manfred Weigele, K.F. West, Kin Chun Luk, Dennis D. Keith, David L. Pruess
Publikováno v:
Bioorganicmedicinal chemistry. 1(3)
A series of alpha-methylene penicillins was synthesized and SAR were studied. The alpha-isomers were found to be chemically reactive and biologically active in contrast to the beta-isomers. In addition, the alpha-isomers have broader spectrum of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea08d495ba1813a52d19b4ba6575c40
https://pubmed.ncbi.nlm.nih.gov/8081849
https://pubmed.ncbi.nlm.nih.gov/8081849
Autor:
Joel Unowsky, Alfred John Corraz, Scott L. Dax, Rossman Pamela Loreen, N H Georgopapadakou, David L. Pruess, Rudolf L. Then, Norma K. Dunlap, Dennis D. Keith, Chung Chen Wei
Publikováno v:
Journal of medicinal chemistry. 35(10)
Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8b936346ea2f91bc48d5bfbb80415e
https://pubmed.ncbi.nlm.nih.gov/1588561
https://pubmed.ncbi.nlm.nih.gov/1588561
Autor:
Pat F. Bevilacqua, John Lawson Roberts, Dennis D. Keith, Pawson Beverly A, Rossman Pamela Loreen, David L. Pruess
Publikováno v:
The Journal of antibiotics. 45(3)
The synthesis and in vitro antibacterial activity of a series of 6-oxygenated penicillanic acid sulfoxides is described. 6 alpha-Hydroxypenicillanic acid-S(S)-oxide (1a) exhibits weak Gram-negative antibacterial activity and appears to be similar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0cc39d2040e7dc34ab3758f603f8d71
https://pubmed.ncbi.nlm.nih.gov/1315728
https://pubmed.ncbi.nlm.nih.gov/1315728