Výsledky vyhledávání - "Rosslyn Grosely"

eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining

Autor: Christopher P. Lapointe, Rosslyn Grosely, Masaaki Sokabe, Carlos Alvarado, Jinfan Wang, Elizabeth Montabana, Nancy Villa, Byung-Sik Shin, Thomas E. Dever, Christopher S. Fraser, Israel S. Fernández, Joseph D. Puglisi

Publikováno v: Nature, vol 607, iss 7917
Nature

Translation initiation defines the identity and quantity of a synthesized protein. The process is dysregulated in many human diseases1,2. A key commitment step is when the ribosomal subunits join at a translation start site on a messenger RNA to form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2eaa553481dbec6647d6a7bc376aca
https://doi.org/10.1038/s41586-022-04858-z

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eIF5B and eIF1A remodel human translation initiation complexes to mediate ribosomal subunit joining

Joining of the ribosomal subunits at a translation start site on a messenger RNA during initiation commits the ribosome to synthesize a protein. Here, we combined single-molecule spectroscopy and structural methods using an in vitro reconstituted sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96c7251689a0aae8948552dda76f4587
https://doi.org/10.1101/2021.12.09.471821

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Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

Autor: Israel S. Fernández, Jinfan Wang, Alex G. Johnson, Rosslyn Grosely, Joseph D. Puglisi, Christopher P. Lapointe

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences

Significance SARS-CoV-2 is the causative agent of the COVID-19 pandemic. A molecular framework for how the virus manipulates host cellular machinery to facilitate infection is needed. Here, we integrate biochemical and single-molecule strategies to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c21ded28e92cb8f9984510c26f28f5
http://europepmc.org/articles/PMC8017934

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Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

Autor: Jinfan Wang, Israel S. Fernández, Joseph D. Puglisi, Rosslyn Grosely, Christopher P. Lapointe, Alex G. Johnson

SARS-CoV-2 recently emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A molecular framework of how the virus manipulates host cellular machinery to facilitate infection remains unclear. Here, we focus on SARS-CoV-2 NSP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34588fbeecdd04d01bfef6b0204ec112
https://doi.org/10.1101/2020.08.20.259770

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RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats

Publikováno v: Nat Neurosci
Nature neuroscience
Nature Neuroscience

Nucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Unconventional translation (RAN translation) of C9orf72 repeats generates dipeptide repeat proteins that can caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9a6ec2cf192f964bb2b5ce13350b5d
https://hdl.handle.net/21.11116/0000-000B-3F43-4

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Inhibition of insulin-like growth factor II (IGF-II)-dependent cell growth by multidentate pentamannosyl 6-phosphate-based ligands targeting the mannose 6-phosphate/IGF-II receptor

Autor: Christopher M. Connelly, Megan E. Zavorka, Rosslyn Grosely, Richard G. MacDonald

Publikováno v: Oncotarget

// Megan E. Zavorka 1, * , Christopher M. Connelly 1, * , Rosslyn Grosely 1 , Richard G. MacDonald 1 1 Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA * These authors have contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563240cf015882ff1e4829a15eb6a93e
http://europepmc.org/articles/PMC5308735

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Expanding single-molecule fluorescence spectroscopy to capture complexity in biology

Autor: Joseph D. Puglisi, Rosslyn Grosely, Junhong Choi, Elisabetta Viani Puglisi

Publikováno v: Curr Opin Struct Biol

Fundamental biological processes are driven by diverse molecular machineries. In recent years, single-molecule fluorescence spectroscopy has matured as a unique tool in biology to study how structural dynamics of molecular complexes drive various bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cd46d587d44fb9fb2dd21546e79ec9
https://pubmed.ncbi.nlm.nih.gov/31213390

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How Messenger RNA and Nascent Chain Sequences Regulate Translation Elongation

Autor: Christopher P. Lapointe, Jinfan Wang, Rosslyn Grosely, Junhong Choi, Joseph D. Puglisi, Arjun Prabhakar

Publikováno v: Annual review of biochemistry. 87

Translation elongation is a highly coordinated, multistep, multifactor process that ensures accurate and efficient addition of amino acids to a growing nascent-peptide chain encoded in the sequence of translated messenger RNA (mRNA). Although transla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e2405aa1aade67900e656068be9153
https://pubmed.ncbi.nlm.nih.gov/29925264

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Secondary structural analysis of the carboxyl-terminal domain from different connexin isoforms

Autor: Gaelle Spagnol, MonaH. Al‐Mugotir, Sydney Zach, Matthew Cervantes, Hanjun Li, Andrew J. Trease, Rosslyn Grosely, Jennifer L. Kopanic, Paul L. Sorgen, Kelly L. Stauch

Publikováno v: Biopolymers. 105:143-162

The connexin carboxyl-terminal (CxCT) domain plays a role in the trafficking, localization, and turnover of gap junction channels, as well as the level of gap junction intercellular communication via numerous post-translational modifications and prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::483c43b154a982271ba034fe8f9b49af
https://doi.org/10.1002/bip.22762

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Effects of Phosphorylation on the Structure and Backbone Dynamics of the Intrinsically Disordered Connexin43 C-terminal Domain

Autor: Sydney Zach, Rosslyn Grosely, Gaelle Spagnol, Fabien Kieken, Mona Al-Mugotir, Sarah Nabors, Paul L. Sorgen, Jennifer L. Kopanic

Publikováno v: Journal of Biological Chemistry. 288:24857-24870

Phosphorylation of the connexin43 C-terminal (Cx43CT) domain regulates gap junction intercellular communication. However, an understanding of the mechanisms by which phosphorylation exerts its effects is lacking. Here, we test the hypothesis that pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9a66f6b28edcf63ca57793307952b2
https://doi.org/10.1074/jbc.m113.454389

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