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Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions

Autor: Flickinger, Kyle M., Wilson, Kelli M., Rossiter, Nicholas J., Hunger, Andrea L., Lee, Tobie D., Hall, Matthew D., Cantor, Jason R.

Publikováno v: bioRxiv

Chemical screening studies have identified drug sensitivities across hundreds of cancer cell lines but most putative therapeutics fail to translate. Discovery and development of drug candidates in models that more accurately reflect nutrient availabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e3dbfed2a6403dc8bbf44b5a9a707fe
https://europepmc.org/articles/PMC10274668/

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer.

Autor: Cheng C; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA., Hu J; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, PRC., Mannan R; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Bhattacharyya R; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Rossiter NJ; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA., Magnuson B; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Wisniewski JP; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA., Zheng Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Xiao L; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Li C; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PRC., Awad D; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., He T; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA.; Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, PRC., Bao Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Zhang Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Cao X; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA., Wang Z; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PRC., Mehra R; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Morlacchi P; Agilent Technologies, Inc., Lexington, MA, USA., Sahai V; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., di Magliano MP; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Shah YM; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Ding K; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PRC., Qiao Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Lyssiotis CA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Chinnaiyan AM; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Urology, University of Michigan, Ann Arbor, MI, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 20. Date of Electronic Publication: 2024 Mar 20.

Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions.

Autor: Flickinger KM, Wilson KM, Rossiter NJ, Hunger AL, Lee TD, Hall MD, Cantor JR

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 06. Date of Electronic Publication: 2023 Jun 06.