Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology

Autor: Rossin, EJ, Lage, K, Raychaudhuri, S, Xavier, RJ, Tatar, D, Benita, Y, COTTONE, Mario

Genome-wide association studies (GWAS) have defined over 150 genomic regions unequivocally containing variation predisposing to immune-mediated disease. Inferring disease biology from these observations, however, hinges on our ability to discover the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3658::a68c35bafdbca6baae9890b6ef2a7ad3
http://hdl.handle.net/10447/63635

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Autor: den Hoed, M, Eijgelsheim, M, Esko, T, Brundel, Bj, Peal, Ds, Evans, Dm, Nolte, Im, Segrè, Av, Holm, H, Handsaker, Re, Westra, Hj, Johnson, T, Isaacs, A, Yang, J, Lundby, A, Zhao, Jh, Kim, Yj, Go, Mj, Almgren, P, Bochud, M, Boucher, G, Cornelis, Mc, Gudbjartsson, D, Hadley, D, van der Harst, P, Hayward, C, den Heijer, M, Igl, W, Jackson, Au, Kutalik, Z, Luan, J, Kemp, Jp, Kristiansson, K, Ladenvall, C, Lorentzon, M, Montasser, Me, Njajou, Ot, O'Reilly, Pf, Padmanabhan, S, St Pourcain, B, Rankinen, T, Salo, P, Tanaka, T, Timpson, Nj, Vitart, V, Waite, L, Wheeler, W, Zhang, W, Draisma, Hh, Feitosa, Mf, Kerr, Kf, Lind, Pa, Mihailov, E, Onland Moret NC, Song, C, Weedon, Mn, Xie, W, Yengo, L, Absher, D, Albert, Cm, Alonso, A, Arking, De, de Bakker PI, Balkau, B, Barlassina, C, Benaglio, P, Bis, Jc, Bouatia Naji, N, Brage, S, Chanock, Sj, Chines, Ps, Chung, M, Darbar, D, Dina, C, Dörr, M, Elliott, P, Felix, Sb, Fischer, K, Fuchsberger, C, de Geus EJ, Goyette, P, Gudnason, V, Harris, Tb, Hartikainen, Al, Havulinna, As, Heckbert, Sr, Hicks, Aa, Hofman, A, Holewijn, S, Hoogstra Berends, F, Hottenga, Jj, Jensen, Mk, Johansson, A, Junttila, J, Kääb, S, Kanon, B, Ketkar, S, Khaw, Kt, Knowles, Jw, Kooner, As, Kors, Ja, Kumari, M, Milani, L, Laiho, P, Lakatta, Eg, Langenberg, C, Leusink, M, Liu, Y, Luben, Rn, Lunetta, Kl, Lynch, Sn, Markus, Mr, Marques Vidal, P, Mateo Leach, I, Mcardle, Wl, Mccarroll, Sa, Medland, Se, Miller, Ka, Montgomery, Gw, Morrison, Ac, Müller Nurasyid, M, Navarro, P, Nelis, M, O'Connell, Jr, O'Donnell, Cj, Ong, Kk, Newman, Ab, Peters, A, Polasek, O, Pouta, A, Pramstaller, Pp, Psaty, Bm, Rao, Dc, Ring, Sm, Rossin, Ej, Rudan, D, Sanna, S, Scott, Ra, Sehmi, Js, Sharp, S, Shin, Jt, Singleton, Ab, Smith, Av, Soranzo, N, Spector, Td, Stewart, C, Stringham, Hm, Tarasov, Kv, Uitterlinden, Ag, Vandenput, L, Hwang, Sj, Whitfield, Jb, Wijmenga, C, Wild, Sh, Willemsen, G, Wilson, Jf, Witteman, Jc, Wong, A, Wong, Q, Jamshidi, Y, Zitting, P, Boer, Jm, Boomsma, Di, Borecki, Ib, van Duijn CM, Ekelund, U, Forouhi, Ng, Froguel, P, Hingorani, A, Ingelsson, E, Kivimaki, M, Kronmal, Ra, Kuh, D, Lind, L, Martin, Ng, Oostra, Ba, Pedersen, Nl, Quertermous, T, Rotter, Ji, van der Schouw YT, Verschuren, Wm, Walker, M, Albanes, D, Arnar, Do, Assimes, Tl, Bandinelli, S, Boehnke, M, de Boer RA, Bouchard, C, Caulfield, Wl, Chambers, Jc, Curhan, G, Cusi, D, Eriksson, J, Ferrucci, L, van Gilst WH, Glorioso, N, de Graaf, J, Groop, L, Gyllensten, U, Hsueh, Wc, Hu, Fb, Huikuri, Hv, Hunter, Dj, Iribarren, C, Isomaa, B, Jarvelin, Mr, Jula, A, Kähönen, M, Kiemeney, La, van der Klauw MM, Kooner, Js, Kraft, P, Iacoviello, Licia, Lehtimäki, T, Lokki, Ml, Mitchell, Bd, Navis, G, Nieminen, Ms, Ohlsson, C, Poulter, Nr, Qi, L, Raitakari, Ot, Rimm, Eb, Rioux, Jd, Rizzi, F, Rudan, I, Salomaa, V, Sever, Ps, Shields, Dc, Shuldiner, Ar, Sinisalo, J, Stanton, Av, Stolk, Rp, Strachan, Dp, Tardif, Jc, Thorsteinsdottir, U, Tuomilehto, J, van Veldhuisen DJ, Virtamo, J, Viikari, J, Vollenweider, P, Waeber, G, Widen, E, Cho, Ys, Olsen, Jv, Visscher, Pm, Willer, C, Franke, L, Global BPgen Consortium, Cardiogram, Consortium, Erdmann, J, Thompson, Jr, PR GWAS Consortium, Pfeufer, A, QRS GWAS Consortium, Sotoodehnia, N, QT IGC Consortium, Newton Cheh, C, CHARGE AF Consortium, Ellinor, Pt, Stricker, Bh, Metspalu, A, Perola, M, Beckmann, Js, Smith, Gd, Stefansson, K, Wareham, Nj, Munroe, Pb, Sibon, Oc, Milan, Dj, Snieder, H, Samani, Nj, Loos, R. J.

Publikováno v: den Hoed, M, Eijgelsheim, M, Esko, T, Brundel, B J J M, Peal, D S, Evans, D M, Nolte, I M, Segrè, A V, Holm, H, Handsaker, R E, Westra, H-J, Johnson, T, Isaacs, A, Yang, J, Lundby, A, Zhao, J H, Kim, Y J, Go, M J, Almgren, P, Bochud, M, Boucher, G, Cornelis, M C, Gudbjartsson, D, Hadley, D, van der Harst, P, Hayward, C, den Heijer, M, Igl, W, Jackson, A U, Kutalik, Z, Luan, J, Kemp, J P, Kristiansson, K, Ladenvall, C, Lorentzon, M, Montasser, M E, Njajou, O T, O'Reilly, P F, Padmanabhan, S, St Pourcain, B, Rankinen, T, Salo, P, Tanaka, T, Timpson, N J, Vitart, V, Navarro, P, Polasek, O, Wild, S H & Wilson, J F & Rudan, I 2013, ' Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders ', Nature Genetics, vol. 45, no. 6, pp. 621-. https://doi.org/10.1038/ng.2610
Nature Genetics, vol. 45, no. 6, pp. 621-631
Nature Genetics, 45(6), 621-631. Nature Publishing Group
Nature Genetics, 45(6), 621-31. Nature Publishing Group
Nature Genetics, 45, 621-31
Nature Genetics, 45(6), 621-+. Nature Publishing Group
Nature Genetics, 45, 6, pp. 621-31
den Hoed, M A H, Eijgelsheim, M, Esko, T, Brundel, B J, Peal, D S, Evans, D M, Nolte, I M, Segrè, A V, Holm, H, Handsaker, R E, Westra, H J, Johnson, T, Isaacs, A, Yang, L, Lundby, A, Zhao, J H, Kim, Y J, Go, M J, Almgren, P, Bochud, M, Boucher, G, Cornelis, M C, Gudbjartsson, D F, Hadley, D, van der Harst, P, Hayward, C, den Heijer, M, Igl, W, Jackson, A U, Kutalik, Z, Luan, J, Kemp, J P, Kristiansson, K, Ladenvall, C, Lorentzon, M, Montasser, M E, Njajou, O T, O'Reilly, P F, Padmanabhan, S, St Pourcain, B, Rankinen, T, Salo, P, Tanaka, T, Timpson, N J, Vitart, V, Waite, L, Wheeler, W, Zhang, W, Draisma, H H M, Feitosa, M F, Kerr, K F, Lind, P A, Mihailov, E, Onland-Moret, N C, Song, C, Weedon, M N, Xie, W, Yengo, L, Absher, D, Albert, C M, Alonso, A, Arking, D E, de Bakker, P I, Balkau, B, Barlassina, C, Benaglio, P, Bis, J C, Bouatia-Naji, N, Brage, S, Chanock, S J, Chines, P S, Chung, M, Darbar, D, Dina, C, Dörr, M, Elliott, P, Felix, S B, Fischer, K, Fuchsberger, C, de Geus, E J C, Goyette, P, Gudnason, V, Harris, T B, Hartikainen, A L, Havulinna, A S, Heckbert, S R, Hicks, A A, Hofman, A, Holewijn, S, Hoogstra-Berends, F, Hottenga, J J, Jensen, M K, Johansson, A, Junttila, J, Kääb, S, Kanon, B, Ketkar, S, Khaw, K T, Knowles, J W, Kooner, A S, Kors, J A, Kumari, M, Milani, L, Laiho, P, Lakatta, E G, Langenberg, C, Leusink, M, Liu, Y, Luben, R N, Lunetta, K L, Lynch, S N, Markus, M R, Marques-Vidal, P, Mateo Leach, I, McArdle, W L, McCarroll, S A, Medland, S E, Miller, K A, Montgomery, G W, Morrison, A C, Müller-Nurasyid, M, Navarro, P, Nelis, M, O'Connell, J R, O'Donnell, C J, Ong, K K, Newman, A B, Peters, A, Polasek, O, Pouta, A, Pramstaller, P P, Psaty, B M, Rao, D C, Ring, S M, Rossin, E J, Rudan, D, Sanna, S, Scott, R A, Sehmi, J S, Sharp, S, Shin, J T, Singleton, A B, Smith, A V, Soranzo, N, Spector, T D, Stewart, C, Stringham, H M, Tarasov, K V, Uitterlinden, A G, Vandenput, L, Hwang, S J, Whitfield, J B, Wijmenga, C, Wild, S H, Willemsen, G, Wilson, J F, Witteman, J C, Wong, A, Wong, Q, Jamshidi, Y, Zitting, P, Boer, J M, Boomsma, D I, Borecki, I B, van Duijn, C M, Ekelund, U, Forouhi, N G, Froguel, P, Hingorani, A D, Ingelsson, E, Kivimaki, M, Kronmal, R A, Kuh, D, Lind, L, Martin, N G, Oostra, B A, Pedersen, N L, Quertermous, T, Rotter, J I, van der Schouw, Y T, Verschuren, W M, Walker, M, Albanes, D, Arnar, D O, Assimes, T L, Bandinelli, S, Boehnke, M, de Boer, R A, Bouchard, C, Caulfield, W L, Chambers, J C, Curhan, G, Cusi, D, Eriksson, J, Ferrucci, L, van Gilst, W H, Glorioso, N, de Graaf, J, Groop, L, Gyllensten, U, Hsueh, W C, Hu, F B, Huikuri, H V, Hunter, D J, Iribarren, C, Isomaa, B, Järvelin, M R, Jula, A, Kähönen, M, Kiemeney, L A, van der Klauw, M M, Kooner, J S, Kraft, P, Iacoviello, L, Lehtimäki, T, Lokki, M L, Mitchell, B D, Navis, G, Nieminen, M S, Ohlsson, C, Poulter, N R, Qi, L, Raitakari, O T, Rimm, E B, Rioux, J D, Rizzi, F, Rudan, I, Salomaa, V, Sever, P S, Shields, D C, Shuldiner, A R, Sinisalo, J, Stanton, A V, Stolk, R P, Strachan, D P, Tardif, J C, Thorsteinsdottir, U, Tuomilehto, J, van Veldhuisen, D J, Virtamo, J, Viikari, J, Vollenweider, P, Waeber, G, Widen, E, Cho, Y S, Olsen, J V, Visscher, P M, Willer, C J, Franke, L, Erdmann, J, Thompson, J R, Pfeufer, A, Sotoodehnia, N, Newton-Cheh, C, Ellinor, P T, Stricker, B H C, Metspalu, A, Perola, M, Beckmann, J S, Smith, G D, Stefansson, K, Wareham, N J, Munroe, P B, Sibon, O C M, Milan, D J, Snieder, H, Samani, N J & Loos, R J 2013, ' Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders ', Nature Genetics, vol. 45, no. 6, pp. 621-631 . https://doi.org/10.1038/ng.2610
Nature Genetics

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f091499ff4331cd37912032e3ea160
https://acuresearchbank.acu.edu.au/item/85846/identification-of-heart-rate-associated-loci-and-their-effects-on-cardiac-conduction-and-rhythm-disorders

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Central Retinal Artery Occlusion Following Sphenopalatine Artery Embolization: A Case Report and Review of the Literature.

Autor: Zhou HW; Department of Ophthalmology, Harvard Medical School, Boston, MA., Foulsham W, Rossin EJ

Publikováno v: Retinal cases & brief reports [Retin Cases Brief Rep] 2024 Oct 21. Date of Electronic Publication: 2024 Oct 21.

Targeting the Tie-2 Receptor With Faricimab in Central Serous Chorioretinopathy: A Case Series Motivated by a Genetic Finding.

Autor: Rämö JT; From the Broad Institute of MIT and Harvard (J.T.R., E.J.R.), Cambridge, Massachusetts, USA; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE) (J.T.R.), University of Helsinki, Helsinki, Finland; Massachusetts Eye and Ear (J.T.R., D.E., L.S., D.G.V., E.J.R.), Boston, Massachusetts, USA., Kim LA; Department of Ophthalmology (L.A.K., P.P.S., R.B., D.E., L.S., D.G.V., E.J.R.), Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA., Stryjewski T; Tallman Eye Associates (T.S.), Lawrence, Massachusetts, USA., Shah PP; Department of Ophthalmology (L.A.K., P.P.S., R.B., D.E., L.S., D.G.V., E.J.R.), Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA., Bejjani R; Department of Ophthalmology (L.A.K., P.P.S., R.B., D.E., L.S., D.G.V., E.J.R.), Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA., Brodie FL; Department of Ophthalmology (F.L.B), University of San Francisco California, San Francisco, California, USA., Eliott D; Massachusetts Eye and Ear (J.T.R., D.E., L.S., D.G.V., E.J.R.), Boston, Massachusetts, USA; Department of Ophthalmology (L.A.K., P.P.S., R.B., D.E., L.S., D.G.V., E.J.R.), Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA., Sobrin L; Massachusetts Eye and Ear (J.T.R., D.E., L.S., D.G.V., E.J.R.), Boston, Massachusetts, USA; Department of Ophthalmology (L.A.K., P.P.S., R.B., D.E., L.S., D.G.V., E.J.R.), Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA., Vavvas DG; Massachusetts Eye and Ear (J.T.R., D.E., L.S., D.G.V., E.J.R.), Boston, Massachusetts, USA; Department of Ophthalmology (L.A.K., P.P.S., R.B., D.E., L.S., D.G.V., E.J.R.), Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA., Rossin EJ; From the Broad Institute of MIT and Harvard (J.T.R., E.J.R.), Cambridge, Massachusetts, USA; Massachusetts Eye and Ear (J.T.R., D.E., L.S., D.G.V., E.J.R.), Boston, Massachusetts, USA; Department of Ophthalmology (L.A.K., P.P.S., R.B., D.E., L.S., D.G.V., E.J.R.), Harvard Medical School, Massachusetts Eye and Ear, Boston, Massachusetts, USA. Electronic address: Elizabeth_rossin@meei.harvard.edu.

Publikováno v: American journal of ophthalmology [Am J Ophthalmol] 2024 Sep 02; Vol. 269, pp. 246-254. Date of Electronic Publication: 2024 Sep 02.