Výsledky vyhledávání - "Rossi P. Naoumova"

Akademický článek

CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients[S]

Publikováno v: Journal of Lipid Research, Vol 54, Iss 12, Pp 3491-3505 (2013)

The purpose of this study was to determine the core biological processes perturbed in the subcutaneous adipose tissue of familial combined hyperlipidemia (FCHL) patients. Annotation of FCHL and control microarray datasets revealed a distinctive FCHL

Externí odkaz: https://doaj.org/article/099d6a65d00b49c4bdc385821c579ab0

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The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism

Autor: Carol C. Shoulders, Xia Yang, Stuart Horswell, William O.C.M. Cookson, Eric E. Schadt, Claire E. Hutchison, Helen E. Speedy, M. Salm, Rossi P. Naoumova, Liming Liang, Anthony S. Wierzbicki

Publikováno v: Genome Research. 22:1144-1153

Genomic inversions are an increasingly recognized source of genetic variation. However, a lack of reliable high-throughput genotyping assays for these structures has precluded a full understanding of an inversion's phylogenetic, phenotypic, and popul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1ea2649d35c2ae115b8a89a1fb08c6
https://doi.org/10.1101/gr.126037.111

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Quantitative 3T MR Imaging of the Descending Thoracic Aorta: Patients with Familial Hypercholesterolemia Have an Increased Aortic Plaque Burden Despite Long-Term Lipid-lowering Therapy

Autor: Isabella Tosi, Rossi P. Naoumova, Joseph V. Hajnal, Elizabeth Potter, Stephan A. Schmitz, Julie Fitzpatrick, Declan P. O'Regan, Clare Neuwirth

Publikováno v: Journal of Vascular and Interventional Radiology. 19:1403-1408

To compare the aortic plaque burden in patients with heterozygous familial hypercholesterolemia on long-term statin treatment with that of matched control subjects.The authors studied 11 heterozygous, nonsmoking, nondiabetic, and nonhypertensive pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a7c631c0583ea7ba04fe5ba5fd486d
https://doi.org/10.1016/j.jvir.2008.06.020

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Liver Fat Content and T2*: Simultaneous Measurement by Using Breath-hold Multiecho MR Imaging at 3.0 T—Feasibility

Autor: Joseph V. Hajnal, Julie Fitzpatrick, Marzena Wylezinska-Arridge, Rossi P. Naoumova, Martina F. Callaghan, Stephan A. Schmitz, Declan P. O'Regan

Publikováno v: Radiology. 247:550-557

Research ethics committee approval was obtained for this study, and written informed consent was obtained from all participants. The purpose was to prospectively evaluate the feasibility of breath-hold multiecho in- and out-of-phase magnetic resonanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b4f888b9a97de44fece25587f3b74e
https://doi.org/10.1148/radiol.2472070880

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Cardiac T2* and lipid measurement at 3.0 T-initial experience

Autor: Joseph V. Hajnal, Martina F. Callaghan, Stephan A. Schmitz, Julie Fitzpatrick, Declan P. O'Regan, Rossi P. Naoumova

Publikováno v: European Radiology. 18:800-805

This study was designed to assess whether breath-hold cardiac multiecho imaging at 3.0 T is achievable without significant image artefacts and if fat/water phase interference modulates the exponential T2* signal decay. Twelve healthy volunteers (mean

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681c80d3b33df2e946f04ec539040134
https://doi.org/10.1007/s00330-007-0814-8

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Pioglitazone Improves Myocardial Blood Flow and Glucose Utilization in Nondiabetic Patients With Combined Hyperlipidemia

Autor: Marco Mongillo, Mary Seed, Rossi P. Naoumova, John Betteridge, Heiko Kindler, Muhammad Tahir Khan, Lucia Leccisotti, Paolo G. Camici, Clare Neuwirth, Paul Holvoet

Publikováno v: Journal of the American College of Cardiology. 50:2051-2058

Objectives This study’s aim was to examine whether treatment with pioglitazone, added to conventional lipid-lowering therapy, would improve myocardial glucose utilization (MGU) and blood flow (MBF) in nondiabetic patients with familial combined hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e852de3a8e818e1bc7e0506dcea703f
https://doi.org/10.1016/j.jacc.2007.07.070

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Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: Relation to liver, muscle and regional body fat content

Autor: Mary Seed, Elizabeth Potter, Robert Hughes, Christopher North, Jimmy D. Bell, Julie Fitzpatrick, Isabella Tosi, Gavin Hamilton, Paul Holvoet, Vian Amber, E. Louise Thomas, Rossi P. Naoumova, D. John Betteridge

Publikováno v: Atherosclerosis. 195:e181-e190

Familial combined hyperlipidaemia (FCHL) is a complex genetic disorder conferring high risk of premature atherosclerosis, characterized by high cholesterol and/or triglyceride, low high density lipoprotein (HDL) cholesterol and insulin resistance. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c25ab31de641512cb6b3ca60f86a97d
https://doi.org/10.1016/j.atherosclerosis.2007.03.043

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Genetic defects causing familial hypercholesterolaemia: Identification of deletions and duplications in the LDL-receptor gene and summary of all mutations found in patients attending the Hammersmith Hospital Lipid Clinic

Autor: Anne K. Soutar, Isabella Tosi, Clare Neuwirth, Paola Toledo-Leiva, Rossi P. Naoumova

Publikováno v: Atherosclerosis. 194:102-111

Familial hypercholesterolaemia (FH) results from defective catabolism of low density lipoproteins (LDL), leading to premature atherosclerosis and early coronary heart disease. It is commonly caused by mutations in LDLR , encoding the LDL receptor tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f938d191b81edb41f4725ede1839f3
https://doi.org/10.1016/j.atherosclerosis.2006.10.003

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Improved cardiovascular outcomes following temporal advances in lipid-lowering therapy in a genetically-characterised cohort of familial hypercholesterolaemia homozygotes

Autor: Mary Seed, Gilbert R. Thompson, Shahenaz Walji, James Scott, Anne K. Soutar, Nicolas B. Myant, Timothy J. Aitman, Clare Neuwirth, Rossi P. Naoumova

Background and aims There is a paucity of data concerning the influence of lipid-lowering therapy on cardiovascular (CV) outcomes in patients with homozygous familial hypercholesterolaemia (FH). To redress this a retrospective analysis was undertaken

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9886995ea5c696a063b6e8f86706fc96
http://hdl.handle.net/10044/1/64546

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Severe Hypercholesterolemia in Four British Families With the D374Y Mutation in the PCSK9 Gene

Autor: Charles van Heyningen, Anne K. Soutar, Isabella Tosi, Rossi P. Naoumova, Dilip D. Patel, Stuart Horswell, Clare Neuwirth, A. David Marais

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 25:2654-2660

Objective— Analysis of long-term (30 years) clinical history and response to treatment of 13 patients with the D374Y mutation of PCSK9 (PCSK9 patients) from 4 unrelated white British families compared with 36 white British patients with heterozygou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fff81131a910bf198ee0eca99ad7acb
https://doi.org/10.1161/01.atv.0000190668.94752.ab

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