Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Rossana Pesi"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6735 (2024)
Tumor cells reprogram their metabolism to meet the increased demand for nucleotides and other molecules necessary for growth and proliferation. In fact, cancer cells are characterized by an increased “de novo” synthesis of purine nucleotides. The
Externí odkaz:
https://doaj.org/article/5b23954a753b4dffa96acb1482655ec9
Autor:
Lorenzo Guidotti, Elena Tomassi, Silvia Marracci, Michele Lai, Dominga Lapi, Rossana Pesi, Laura Pucci, Ettore Novellino, Elisabetta Albi, Mercedes Garcia-Gil
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17416 (2023)
Cisplatin is a chemotherapeutic drug for the treatment of several solid tumors, whose use is limited by its nephrotoxicity, neurotoxicity, ototoxicity, and development of resistance. The toxicity is caused by DNA cross-linking, increase in reactive o
Externí odkaz:
https://doaj.org/article/5ea313a2ee9c4f179ade2b2e8fa81be7
Autor:
Marcella Camici, Mercedes Garcia-Gil, Simone Allegrini, Rossana Pesi, Giulia Bernardini, Vanna Micheli, Maria Grazia Tozzi
Publikováno v:
Metabolites, Vol 13, Iss 7, p 787 (2023)
Cellular purine nucleotides derive mainly from de novo synthesis or nucleic acid turnover and, only marginally, from dietary intake. They are subjected to catabolism, eventually forming uric acid in humans, while bases and nucleosides may be converte
Externí odkaz:
https://doaj.org/article/c8c2c47cf327432aa1afea27daf20aa2
Publikováno v:
Cancers, Vol 14, Iss 19, p 4959 (2022)
Uric acid is the final product of purine catabolism in man and apes. The serum concentration of uric acid is sex-, age- and diet-dependent and is maintained close to its maximal solubility, indicating that it plays some important role. Indeed, it has
Externí odkaz:
https://doaj.org/article/3696feccc19841aca28de9637870369b
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, mot
Externí odkaz:
https://doaj.org/article/5d37555c401a4b9babdff739c711d13f
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/1079a7b7b87546428fe74b52b43f22ca
Autor:
Rossana Pesi, Simone Allegrini, Mercedes Garcia-Gil, Lucia Piazza, Roberta Moschini, Lars Petter Jordheim, Marcella Camici, Maria Grazia Tozzi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7004 (2021)
Cytosolic 5′-nucleotidase II (cN-II) is an allosteric catabolic enzyme that hydrolyzes IMP, GMP, and AMP. The enzyme can assume at least two different structures, being the more active conformation stabilized by ATP and the less active by inorganic
Externí odkaz:
https://doaj.org/article/6095dfd60b5b4c769ab190646d538f23
Autor:
Rossana Pesi, Simone Allegrini, Francesco Balestri, Mercedes Garcia-Gil, Federico Cividini, Laura Colombaioni, Lars Petter Jordheim, Marcella Camici, Maria Grazia Tozzi
Publikováno v:
Cells, Vol 10, Iss 1, p 182 (2021)
Cytosolic 5′-nucleotidase II (NT5C2) is a highly regulated enzyme involved in the maintenance of intracellular purine and the pyrimidine compound pool. It dephosphorylates mainly IMP and GMP but is also active on AMP. This enzyme is highly expresse
Externí odkaz:
https://doaj.org/article/bd07450f4cf94e8781db2a3b7a186ba6
Publikováno v:
Cancers, Vol 11, Iss 9, p 1354 (2019)
The enzymes of both de novo and salvage pathways for purine nucleotide synthesis are regulated to meet the demand of nucleic acid precursors during proliferation. Among them, the salvage pathway enzymes seem to play the key role in replenishing the p
Externí odkaz:
https://doaj.org/article/0d284fa35ba544fe8dba295b1db956ad
Autor:
Mercedes Garcia-Gil, Marcella Camici, Simone Allegrini, Rossana Pesi, Edoardo Petrotto, Maria Grazia Tozzi
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3598 (2018)
The growing evidence of the involvement of purine compounds in signaling, of nucleotide imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light on purine metabolism, indicating that well known biochemical pathways m
Externí odkaz:
https://doaj.org/article/6c5efcb0c2c7424cadb1d53c477e41f0