Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rossana García-Fernández"'
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137787 (2015)
The Kunitz-type protease inhibitor ShPI-1 inhibits human neutrophil elastase (HNE, Ki = 2.35·10-8 M) but does not interact with the porcine pancreatic elastase (PPE); whereas its P1 site variant, ShPI-1/K13L, inhibits both HNE and PPE (Ki = 1.3·10-
Externí odkaz:
https://doaj.org/article/352e828d435b4524b6d52736a93a4a2e
Autor:
Rossana García-Fernández, Steve Peigneur, Tirso Pons, Carlos Alvarez, Lidice González, María A. Chávez, Jan Tytgat
Publikováno v:
Toxins, Vol 8, Iss 4, p 110 (2016)
The bovine pancreatic trypsin inhibitor (BPTI)-Kunitz-type protein ShPI-1 (UniProt: P31713) is the major protease inhibitor from the sea anemone Stichodactyla helianthus. This molecule is used in biotechnology and has biomedical potential related to
Externí odkaz:
https://doaj.org/article/c40928c6dd5d4627bde4a2c17edf194c
Autor:
Rossana García-Fernández, Isel Pascual, Rafael E. Sánchez, Lidice González, Christian Betzel, Laritza Rojas, María A. Chávez
Publikováno v:
American Journal of Analytical Chemistry. :319-331
Protease inhibitors have been isolated from many variable sources; however, the need to identify and characterize new molecules has increased with the discovery of new therapeutic targets and the lack of specificity of already identified compounds wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9e76df24b20c5836d9793bd264ae192
https://doi.org/10.4236/ajac.2016.74030
https://doi.org/10.4236/ajac.2016.74030
Autor:
María A. Chávez, Rossana García-Fernández, Steve Peigneur, Carlos Alvarez, Tirso Pons, Lidice González, Jan Tytgat
Publikováno v:
Toxins, Vol 8, Iss 4, p 110 (2016)
Toxins; Volume 8; Issue 4; Pages: 110
Toxins
Toxins; Volume 8; Issue 4; Pages: 110
Toxins
The bovine pancreatic trypsin inhibitor (BPTI)-Kunitz-type protein ShPI-1 (UniProt: P31713) is the major protease inhibitor from the sea anemone Stichodactyla helianthus. This molecule is used in biotechnology and has biomedical potential related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21d17ff4f0562a795637230f67f76c6
http://www.mdpi.com/2072-6651/8/4/110
http://www.mdpi.com/2072-6651/8/4/110
Autor:
Lars Redecke, María A. Chávez, Pedro A. Valiente, Christian Betzel, Tirso Pons, Dirk Rehders, Markus Perbandt, Ariel Talavera, Rossana García-Fernández, Yamile González-González
Publikováno v:
Journal of Structural Biology. 180:271-279
Proteins isolated from marine invertebrates are frequently characterized by exceptional structural and functional properties. ShPI-1, a BPTI Kunitz-type inhibitor from the Caribbean Sea anemone Stichodactyla helianthus, displays activity not only aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6ec49b3f882aa8cbaf1091a13c98b5
https://doi.org/10.1016/j.jsb.2012.08.009
https://doi.org/10.1016/j.jsb.2012.08.009
Publikováno v:
Journal of Cellular Biochemistry. 113:2364-2374
Human nucleophosmin/B23 is a phosphoprotein involved in ribosome biogenesis, centrosome duplication, cancer, and apoptosis. Its function, localization, and mobility within cells, are highly regulated by phosphorylation events. Up to 21 phosphosites o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2e918e072d1d656fae4ba2ea8d9fb0
https://doi.org/10.1002/jcb.24108
https://doi.org/10.1002/jcb.24108
Autor:
Christian Betzel, María A. Chávez, Markus Perbandt, Patrick Ziegelmüller, Rossana García-Fernández, Nicolas Piganeau, Ulrich Hahn, Lars Redecke, Dirk Rehders
Publikováno v:
The Journal of biological chemistry. 290(22)
Elastase-like enzymes are involved in important diseases such as acute pancreatitis, chronic inflammatory lung diseases, and cancer. Structural insights into their interaction with specific inhibitors will contribute to the development of novel anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ecc4c0c5a19649008ed02f93de4ada
https://pubmed.ncbi.nlm.nih.gov/25878249
https://pubmed.ncbi.nlm.nih.gov/25878249
Autor:
Yamile González-González, Lars Redecke, Markus Perbandt, Rossana García-Fernández, Dayrom F. Gil, Christian Betzel, Tirso Pons, Arne Meyer, María A. Chávez
The BPTI/Kunitz-type inhibitor family includes several extremely potent serine protease inhibitors. To date, the inhibitory mechanisms have only been studied for mammalian inhibitors. Here, the first crystal structure of a BPTI/Kunitz-type inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06c075269c539e4d06796039941ceb3
https://europepmc.org/articles/PMC3515366/
https://europepmc.org/articles/PMC3515366/
Autor:
Laura Varas, Emilio Lamazares, Dayrom F. Gil, Manuel Mansur, Rossana García-Fernández, Yamile González-González, Mariela Pérez, Maday Alonso-del-Rivero, Joaquín Díaz, María A. Chávez
Publikováno v:
FEMS yeast research. 11(7)
Pichia pastoris is a highly successful system for the large-scale expression of heterologous proteins, with the added capability of performing most eukaryotic post-translational modifications. However, this system has one significant disadvantage - f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963b54ea7c713cc7025ef5b0759c081c
https://pubmed.ncbi.nlm.nih.gov/22093684
https://pubmed.ncbi.nlm.nih.gov/22093684