Allo Beta Cell transplantation: specific features, unanswered questions, and immunological challenge

Autor: Rossana Caldara, Valentina Tomajer, Paolo Monti, Valeria Sordi, Antonio Citro, Raniero Chimienti, Chiara Gremizzi, Davide Catarinella, Stefano Tentori, Vera Paloschi, Raffella Melzi, Alessia Mercalli, Rita Nano, Paola Magistretti, Stefano Partelli, Lorenzo Piemonti

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Type 1 diabetes (T1D) presents a persistent medical challenge, demanding innovative strategies for sustained glycemic control and enhanced patient well-being. Beta cells are specialized cells in the pancreas that produce insulin, a hormone that regul

Externí odkaz: https://doaj.org/article/1fd182f972064ef3a90189fdae70ac20

COVID-19 in Solid Organ Transplant Recipient: Exploring Cumulative Incidence, Seroprevalence and Risk Factors for Disease Severity

Autor: Rossana Caldara, Paola Maffi, Sabrina Costa, Elena Bazzigaluppi, Cristina Brigatti, Vito Lampasona, Paola Magistretti, Fabio Manenti, Ilaria Marzinotto, Silvia Pellegrini, Marina Scavini, Antonio Secchi, Lorenzo Piemonti

Publikováno v: Biology, Vol 10, Iss 12, p 1349 (2021)

Background: Solid organ transplant (SOT) recipients may be at increased risk for severe disease and mortality from COVID-19 because of immunosuppression and prolonged end-stage organ disease. As a transplant center serving a diverse patient populatio

Externí odkaz: https://doaj.org/article/d32107c500c14a8bae4c84bb9d5e8c12

Rene Policistico e trapianto di rene: accesso alla lista d’attesa e post trapianto: risultati della ricerca

Autor: Rossana Caldara

Publikováno v: Giornale di Clinica Nefrologia e Dialisi, Vol 31, Iss 3 (2019)

Autosomal-dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end-stage renal disease (ESRD) worldwide. The number of ADPKD patients who are listed for transplantation or receive a kidney transplant is continuously increasing o

Externí odkaz: https://doaj.org/article/5f7d12f86a764fa68dc789e933e535e6

Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death

Autor: Marilena Gregorini, Elena Ticozzelli, Massimo Abelli, Maria A. Grignano, Eleonora F. Pattonieri, Alessandro Giacomoni, Luciano De Carlis, Antonio Dell’Acqua, Rossana Caldara, Carlo Socci, Andrea Bottazzi, Carmelo Libetta, Vincenzo Sepe, Stefano Malabarba, Federica Manzoni, Catherine Klersy, Giuseppe Piccolo, Teresa Rampino

Publikováno v: Transplant international : official journal of the European Society for Organ Transplantation. 35

Donation after circulatory death (DCD) allows expansion of the donor pool. We report on 11 years of Italian experience by comparing the outcome of grafts from DCD and extracorporeal membrane oxygenation (ECMO) prior to death donation (EPD), a new don

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ce3ed1c12be8ad13e06594537ed2f5
https://pubmed.ncbi.nlm.nih.gov/35210934

Regulatory cell therapy in kidney transplantation (The ONE Study):a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

Autor: Kathryn J. Wood, Birgit Sawitzki, James A. Hutchinson, Leslie Brent, Cristiano Scottà, Christoph Meyenberg, P Friend, Kerry Crisalli, Manuela Battaglia, Natalie M Otto, Ben James, Eva C. Guinan, M. C. Cuturi, Alexander Scheffold, William Petchey, Ulrich Kunzendorf, William J. Burlingham, Fadi Issa, Antonio Secchi, Petra Reinke, Giovanna Lombardi, James F. Markmann, Hans-Dieter Volk, David Game, Matthias Edinger, Norbert Ahrens, Ian S.D. Roberts, Michael Kapinsky, Maria P. Hernandez-Fuentes, Bernhard Banas, Sandra Karitzky, Nathalie Dupas, Carsten A. Böger, Edward K. Geissler, Tewfik Miloud, Stephan Schlickeiser, Paul N. Harden, Qizhi Tang, Gilles Blancho, Tobias Bergler, Karsten Juerchott, Robert I. Lechler, Hans J. Schlitt, Josep M. Grinyó, Laura Contreras-Ruiz, Rossana Caldara, Joanna Hester, Mathias Streitz, A. Bushell, Rachel Hilton, Régis Josien, Stuart J. Knechtle, Robert Öllinger, Laurence A. Turka, Cécile Braudeau, Aurélie Moreau, Peter J. Morris, Jeffrey A. Bluestone, Sang-Mo Kang, Ingrid Mutzbauer, Jeroen B. van der Net

Publikováno v: Sawitzki, B, Harden, P, Reinke, P, Moreau, A, Hutchinson, J A, Game, D S, Tang, Q, Guinan, E, Battaglia, M, Burlingham, W J, Roberts, I, Streitz, M, Josien, R, Böger, C A, Scotta, C, Markmann, J F, Hester, J, Juerchott, K, Braudeau, C, James, B, Contreras-Ruiz, L, van der Net, J B, Bergler, T, Caldara, R, Petchey, W, Edinger, M, Dupas, N, Kapinsky, M, Mutzbauer, I, Otto, N M, Ollinger, R, Hernandez Fuentes, M, Issa, F, Ahrens, N, Meyenberg, C, Karitzky, S, Kunzendorf, U, Knechtle, S J, Grinyo, J, Morris, P J, Brent, L, Bushell, A, Turka, L A, Bluestone, J A, Lechler, R, Schlitt, H J, Cuturi, M C, Schlickeiser, S, Friend, P J, Miloud, T, Scheffold, A, Secchi, A, Crisalli, K, Kang, S-M, Hilton, R, Banas, B, Blancho, G, Volk, H-D, Lombardi, G, Wood, K & Geissler, E K 2020, ' Regulatory cell therapy in kidney transplantation (The ONE Study) : a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials ', The Lancet, vol. 395, no. 10237, pp. 1627-1639 . https://doi.org/10.1016/S0140-6736(20)30167-7
Lancet (London, England), vol 395, iss 10237

Background:Use of cell-based medicinal products (CBMPs) represents a state-of-the-art approach for reducing general immunosuppression in organ transplantation. We tested multiple regulatory CBMPs in kidney transplant trials to establish the safety of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eeb3a2997cd38b689087979f243f237
https://kclpure.kcl.ac.uk/ws/files/125216985/AllTogetherFigs.pdf