Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rossana Aprigliano"'
Autor:
Rossana Aprigliano, Merdane Ezgi Aksu, Stefano Bradamante, Boris Mihaljevic, Wei Wang, Kristin Rian, Nicola P. Montaldo, Kayla Mae Grooms, Sarah L. Fordyce Martin, Diana L. Bordin, Matthias Bosshard, Yunhui Peng, Emil Alexov, Cindy Skinner, Nina-Beate Liabakk, Gareth J. Sullivan, Magnar Bjørås, Charles E. Schwartz, Barbara van Loon
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100240- (2021)
Summary: Essential E3 ubiquitin ligase HUWE1 (HECT, UBA, and WWE domain containing 1) regulates key factors, such as p53. Although mutations in HUWE1 cause heterogenous neurodevelopmental X-linked intellectual disabilities (XLIDs), the disease mechan
Externí odkaz:
https://doaj.org/article/b8557ff56ac14f5fb273cea9a18c581c
Publikováno v:
Life Science Alliance. 6:e202301950
BAZ2A is the epigenetic repressor of rRNA genes that are transcribed by RNA Polymerase I. In prostate cancer (PCa), however, BAZ2A function was shown to go beyond this role since it can also repress other genes that are frequently silenced in metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c299b6208ba51ff7f5e3912a29e78f
https://doi.org/10.26508/lsa.202301950
https://doi.org/10.26508/lsa.202301950
Autor:
Marco Bolis, Rostyslav Kuzyakiv, Raffaella Santoro, Karolina Pietrzak, Guido Sauter, Ronald Simon, Rossana Aprigliano, Jean-Philippe Theurillat, Dominik Bär
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The cell of origin and the temporal order of oncogenic events in tumors play important roles for disease state. This is of particular interest for PCa due to its highly variable clinical outcome. However, these features are difficult to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8630eca0c0698d5556f3cf5fc4f053
https://doi.org/10.1073/pnas.1911673117
https://doi.org/10.1073/pnas.1911673117
Autor:
Sandra C Frommel, Karolina Pietrzak, Seraina Steiger, Rodrigo Peña-Hernández, Marcin Roganowicz, Raffaella Santoro, Juliana Bizzarro, Rossana Aprigliano
Prostate cancer (PCa) is one of the most prevalent cancers in men. Cancer stem cells are thought to be associated with PCa relapse and represent a target against metastatic PCa. Here we show that BAZ2A (also known as TIP5), a factor previously implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ee24a876cf8fbd847d01ca6791efdc
https://doi.org/10.1101/2020.07.03.185843
https://doi.org/10.1101/2020.07.03.185843
Autor:
Anastasia Tsaalbi-Shtylik, Rossana Aprigliano, Niels de Wind, Daniela C.F. Salvatori, Matthias Bosshard, Marc H.G.P. Raaijmakers, Ronald van Os, Celia Dingemanse-van der Spek, Albertina Dethmers-Ausema, Barbara van Loon, Gerald de Haan, Keiji Hashimoto, Masaaki Moriya, Si Chen, Nima Borhan Fakouri, Seka Lazare, Lene Juel Rasmussen, Ana Martín-Pardillos
Publikováno v:
Blood, 130(13), 1523-1534. AMER SOC HEMATOLOGY
Blood, 130(13), 1523-1534
Blood, 130(13), 1523-1534. American Society of Hematology
Blood, 130(13), 1523-1534
Blood, 130(13), 1523-1534. American Society of Hematology
Endogenous DNA damage is causally associated with the functional decline and transformation of stem cells that characterize aging. DNA lesions that have escaped DNA repair can induce replication stress and genomic breaks that induce senescence and ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303237965cefbec89cd518ec17b7d33
https://research.rug.nl/en/publications/aa9f02d3-22fc-43b4-8020-b72d57383feb
https://research.rug.nl/en/publications/aa9f02d3-22fc-43b4-8020-b72d57383feb
Autor:
Guy Froyen, Matthias Altmeyer, Barbara van Loon, F. Lucy Raymond, Matthias Bosshard, Enni Markkanen, Rossana Aprigliano, Cristina Gattiker, Stefania Pellegrino, Grigory L. Dianov, Paul Hoff Backe, Vuk Palibrk, Magnar Bjørås
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Scientific Reports
Scientific Reports
Mutations in the HECT, UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-linked intellectual disability (XLID). HUWE1 regulates essential processes such as genome integrity maintenance. Alterations in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7ba587c83d1c0aa21a115029655951
https://doi.org/10.1038/s41598-018-24189-2
https://doi.org/10.1038/s41598-018-24189-2
Autor:
Paul Hoff Backe, F. Lucy Raymond, Matthias Altmeyer, Magnar Bjørås, Vuk Palibrk, Stefania Pellegrino, Guy Froyen, Barbara van Loon, Rossana Aprigliano, Matthias Bosshard, Cristina Gattiker, Grigory L. Dianov, Enni Markkanen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
Mutations in the HECT, UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-linked intellectual disability (XLID). HUWE1 regulates essential processes such as genome integrity maintenance. Alterations in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d573b2be69ff623ad67a88617f91d6
https://doi.org/10.1038/s41598-017-15380-y
https://doi.org/10.1038/s41598-017-15380-y
Autor:
Sandra C Frommel, Marcin Roganowicz, Luigi Lerra, Raffaella Santoro, Karolina Pietrzak, Rossana Aprigliano, Seraina Steiger, Rodrigo Peña-Hernández, Juliana Bizzarro
Publikováno v:
EMBO Reports
EMBO reports
EMBO reports
Prostate cancer (PCa) is one of the most prevalent cancers in men. Cancer stem cells are thought to be associated with PCa relapse. Here, we show that BAZ2A is required for PCa cells with a cancer stem‐like state. BAZ2A genomic occupancy in PCa cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e27ff0ece415d8b321fcc93b7d9eab