Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ross Thorne"'
Autor:
Zdenka Dudová, Nathalie Conte, Jeremy Mason, Dalibor Stuchlík, Radim Peša, Csaba Halmagyi, Zinaida Perova, Abayomi Mosaku, Ross Thorne, Alex Follette, Ľuboslav Pivarč, Radim Šašinka, Muhammad Usman, Steven Neuhauser, Dale A. Begley, Debra M. Krupke, Massimiliano Frassà, Alessandro Fiori, Riccardo Corsi, Luca Vezzadini, Claudio Isella, Andrea Bertotti, Carol Bult, Helen Parkinson, Enzo Medico, Terrence Meehan, Aleš Křenek
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Patient-derived xenografts (PDX) mice models play an important role in preclinical trials and personalized medicine. Sharing data on the models is highly valuable for numerous reasons – ethical, economical, research cross valida
Externí odkaz:
https://doaj.org/article/f99e9bc8c35f4c12ae94bc2bd9b450b1
Autor:
Nicholas T. Crump, Erica Ballabio, Laura Godfrey, Ross Thorne, Emmanouela Repapi, Jon Kerry, Marta Tapia, Peng Hua, Christoffer Lagerholm, Panagis Filippakopoulos, James O. J. Davies, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The role of BRD4 and Mediator in regulating enhancer-promoter interactions is poorly understood. Here the authors find that treatment with BET inhibitors or pharmacological degradation of BRD4 disrupts transcription while having very little effect on
Externí odkaz:
https://doaj.org/article/8fdcc190846d423ba9cdaa4d7f3a1b96
Autor:
Laura Godfrey, Nicholas T. Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L. Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in
Externí odkaz:
https://doaj.org/article/e4a9cce559524c16a138443251705752
Autor:
Zdenka Dudová, Nathalie Conte, Jeremy Mason, Dalibor Stuchlík, Radim Peša, Csaba Halmagyi, Zinaida Perova, Abayomi Mosaku, Ross Thorne, Alex Follette, Ľuboslav Pivarč, Radim Šašinka, Muhammad Usman, Steven Neuhauser, Dale A. Begley, Debra M. Krupke, Massimiliano Frassà, Alessandro Fiori, Riccardo Corsi, Luca Vezzadini, Claudio Isella, Andrea Bertotti, Carol Bult, Helen Parkinson, Enzo Medico, Terrence Meehan, Aleš Křenek
Publikováno v:
BMC genomics. 23(1)
Background Patient-derived xenografts (PDX) mice models play an important role in preclinical trials and personalized medicine. Sharing data on the models is highly valuable for numerous reasons – ethical, economical, research cross validation etc.
Autor:
Siobhan Rice, Ryan Beveridge, Edward Morrissey, Marella F. T. R. de Bruijn, Thomas A. Milne, Nicholas T. Crump, Tudor A. Fulga, Max Jamilly, Anindita Roy, Ross Thorne, Irene Roberts, Joe Harman, Marta Tapia
Publikováno v:
Genome Res
Regulatory interactions mediated by transcription factors (TFs) make up complex networks that control cellular behavior. Fully understanding these gene regulatory networks (GRNs) offers greater insight into the consequences of disease-causing perturb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be19121ad43f709ac0c572fbf1b4e05f
https://doi.org/10.1101/gr.268490.120
https://doi.org/10.1101/gr.268490.120
Autor:
Zinaida Perova, Csaba Halmagyi, Alex Follette, Mauricio Martinez, Federico Lopez-Gomez, Jeremy Mason, Abayomi Mosaku, Nathalie Conte, Ross Thorne, Steven Neuhauser, Dale Begley, Debra Krupke, Terrence Meehan, Carol Bult, Helen Parkinson
Publikováno v:
Cancer Research. 82:3105-3105
PDCM Finder (https://cancermodels.org) is a new portal that aggregates patient-derived models (xenografts, cell lines and organoids) from 27 academic and commercial providers, enables users to search and compare over 6000 models and associated molecu
Autor:
Emmanouela Repapi, Panagis Filippakopoulos, Erica Ballabio, Christoffer Lagerholm, Peng Hua, Jon Kerry, Thomas A. Milne, Nicholas T. Crump, Laura Godfrey, Marta Tapia, James O.J. Davies, Ross Thorne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Enhancers are DNA sequences that enable complex temporal and tissue-specific regulation of genes in higher eukaryotes. Although it is not entirely clear how enhancer-promoter interactions can increase gene expression, this proximity has been observed
Autor:
Anindita Roy, Nicholas T. Crump, de Bruijn Mftr., Tudor A. Fulga, Irene Roberts, Max Jamilly, Ross Thorne, Ryan Beveridge, Marta Tapia, Joe Harman, Siobhan Rice, Edward Morrissey, Thomas A. Milne
Regulatory interactions mediated by transcription factors (TFs) make up complex networks that control cellular behavior. Fully understanding these gene regulatory networks (GRNs) offers greater insight into the consequences of disease-causing perturb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f0c7f78b82673ed6945083cc0cde6f1
https://doi.org/10.1101/2020.06.30.179796
https://doi.org/10.1101/2020.06.30.179796
Autor:
Dale A. Begley, Mauricio Martinez, Nathalie Conte, Alex W. Follette, Steven B. Neuhauser, Helen Parkinson, Debra M. Krupke, Zinaida Perova, Ross Thorne, Csaba Halmagyi, Abayomi Mosaku, Carol J. Bult, Terrence F. Meehan, Jeremy Mason
Publikováno v:
Cancer Research. 81:LB017-LB017
Patient-derived tumor xenograft (PDX) models are a critical oncology platform for cancer research, drug development and personalized medicine. Because of the heterogeneous nature of PDXs repositories, finding models of interest is a challenge. The Ja
Autor:
Emmanouela Repapi, Ross Thorne, Damien J. Downes, Joe Harman, I-Jun Lau, Jim R. Hughes, Nicholas T. Crump, Thomas A. Milne, Laura Godfrey, Paresh Vyas, Alastair L. Smith, Jelena Telenius, Dimitra Dimou, A. Marieke Oudelaar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Enhancer elements are a key regulatory feature of many important genes. Several general features including the presence of specific histone modifications are used to demarcate potentially active enhancers. Here we reveal that putative enhancers marke