Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart

Autor: Ross T. Lindsay, Philip Ambery, Lutz Jermutus, Andrew J. Murray

Publikováno v: Physiological Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)

Abstract The inotropic effects of glucagon have been recognized for many years, but it has remained unclear whether glucagon signaling is beneficial to cardiac function. We evaluated the effects of glucagon alone and in combination with the glucagon�

Externí odkaz: https://doaj.org/article/87b884012d2c4f36ac251561f7c20681

β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery

Autor: Cecilia Castro, Sophie Dieckmann, Ross T. Lindsay, James A. West, Andrew J. Murray, Dominic Manetta-Jones, Julian L. Griffin, Dominika Krzyzanska

Publikováno v: eLife, Vol 10 (2021)
eLife

Extrahepatic tissues which oxidise ketone bodies also have the capacity to accumulate them under particular conditions. We hypothesised that acetyl-coenzyme A (acetyl-CoA) accumulation and altered redox status during low-flow ischaemia would support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0f68c7a8a535e3a10ed90d4916a711
https://doi.org/10.7554/elife.71270

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy

Autor: Thomas Secher, Philip J. Pedersen, Jacob Jelsing, Lisbeth Nielsen Fink, Louise Thisted, Andrew J. Murray, Sebastian T. Thrane, Nora E. Zois, Tanja X. Pedersen, Torben Skarsfeldt, Morten B. Thomsen, Thea T. Johansen, Ross T. Lindsay, Mette V. Østergaard, Annemarie A. Pedersen

Publikováno v: Thisted, D L A, Østergaard, M V, Pedersen, A A, Pedersen, P J, Lindsay, R T, Murray, A J, Fink, L N, Pedersen, T X, Secher, T, Johansen, T T, Thrane, S T, Skarsfeldt, T, Jelsing, J, Thomsen, M B & Zois, N E 2020, ' Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy ', Scientific Reports, vol. 10, 16130 . https://doi.org/10.1038/s41598-020-73046-8
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Thisted, L, Ostergaard, M, Pedersen, A A, Pedersen, P J, Lindsay, R T, Murray, A J, Fink, L N, Pedersen, T X, Secher, T, Johansen, T T, Thrane, S T, Skarsfeldt, T, Jelsing, J, Thomsen, M B & Zois, N E 2020, ' Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy ', Scientific Reports, vol. 10, no. 1, 16130 . https://doi.org/10.1038/s41598-020-73046-8

Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001006a66b6924921a628f8bcb796c90
https://doi.org/10.1038/s41598-020-73046-8

Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release

Autor: Elizabeth A. Williams, Martin Feelisch, Julian L. Griffin, Ben D. McNally, Mario Siervo, Steven A. Murfitt, Tom Ashmore, Andrew J. Murray, Ross T. Lindsay, Lee D. Roberts, Bernadette O. Fernandez

Publikováno v: Diabetes. 66:674-688

Exercise is an effective intervention for the prevention and treatment of type 2 diabetes. Skeletal muscle combines multiple signals that contribute to the beneficial effects of exercise on cardiometabolic health. Inorganic nitrate increases exercise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f490c17309509447fe3a6654ba92b3ec
https://doi.org/10.2337/db16-0843

PPARα-independent effects of nitrate supplementation on skeletal muscle metabolism in hypoxia

Autor: Katie A, O'Brien, James A, Horscroft, Jules, Devaux, Ross T, Lindsay, Alice Strang, Steel, Anna D, Clark, Andrew, Philp, Stephen D R, Harridge, Andrew J, Murray

Publikováno v: Biochimica et Biophysica Acta. Molecular Basis of Disease

Hypoxia is a feature of many disease states where convective oxygen delivery is impaired, and is known to suppress oxidative metabolism. Acclimation to hypoxia thus requires metabolic remodelling, however hypoxia tolerance may be aided by dietary nit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::912174119e3ce9434c713be375fdbc53
https://pubmed.ncbi.nlm.nih.gov/30055294