Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ross S. Thomas"'
Autor:
Manikandan Periyasamy, Hetal Patel, Chun-Fui Lai, Van T.M. Nguyen, Ekaterina Nevedomskaya, Alison Harrod, Roslin Russell, Judit Remenyi, Anna Maria Ochocka, Ross S. Thomas, Frances Fuller-Pace, Balázs Győrffy, Carlos Caldas, Naveenan Navaratnam, Jason S. Carroll, Wilbert Zwart, R. Charles Coombes, Luca Magnani, Laki Buluwela, Simak Ali
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 108-121 (2015)
Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regions. We
Externí odkaz:
https://doaj.org/article/0888c564b94245ac837fe1a7d55a9dc2
Autor:
Stephen P. Fox, R. Charles Coombes, Xanthippi Alexi, Chun Fui Lai, Fiona Kyle, Silvia Ottaviani, Ross S. Thomas, Hui Hua, Jason S. Carroll, Simak Ali, Holly B. Callaghan, Koen D. Flach, Laki Buluwela, Rosalind Launchbury, Wilbert Zwart, Paul Thiruchelvam
Publikováno v:
Nucleic Acids Research
Oestrogen receptor α (ERα) is a nuclear receptor that is the driving transcription factor expressed in the majority of breast cancers. Recent studies have demonstrated that the liver receptor homolog-1 (LRH-1), another nuclear receptor, regulates b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6d63cc359475625b98508329a05193
Autor:
Simak Ali, Frances V. Fuller-Pace, Laki Buluwela, Luca Magnani, Naveenan Navaratnam, Roslin Russell, Carlos Caldas, Jason S. Carroll, Anna Maria Ochocka, Manikandan Periyasamy, Van T. M. Nguyen, Hetal Patel, Ross S. Thomas, Chun-Fui Lai, Wilbert Zwart, Alison Harrod, Balázs Győrffy, Ekaterina Nevedomskaya, Judit Remenyi, R. Charles Coombes
Publikováno v:
Cell Reports
Cell Reports, Vol 13, Iss 1, Pp 108-121 (2015)
Cell Reports, Vol 13, Iss 1, Pp 108-121 (2015)
Summary Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b663f5091c6a5cc46f7b2d488a399b18
https://doi.org/10.1016/j.celrep.2015.08.066
https://doi.org/10.1016/j.celrep.2015.08.066
Autor:
Leigh H. McKinlay, Martin J. Tymms, Ross S. Thomas, Arun Seth, Suzanne Hasthorpe, Paul J. Hertzog, Ismail Kola
Publikováno v:
The Journal of Immunology. 161:4098-4105
Ets-1 is a transcription factor with restricted expression in lymphocytes, and it has been implicated in the regulation of T cell genes such as TCRα, TCRβ, CD4, IL-2, and TNF-α. We show in this study that Ets-1 is also expressed in some mast cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b014cfcac087fc92090b91e5da01a924
https://doi.org/10.4049/jimmunol.161.8.4098
https://doi.org/10.4049/jimmunol.161.8.4098
Autor:
Ismail Kola, Ross S Thomas, Christine Debouck, Arun Seth, Jiong Zhou, Martin J. Tymms, Brian C. Schutte, Martin Rosenberg, Takis S. Papas, Annie Yn Ng, Grant R. Sutherland, Helen J. Eyre
Publikováno v:
Oncogene. 15:2449-2462
The ETS family of genes are implicated in cancers such as Ewings sarcoma, acute myeloid leukemia and chronic myelomonocytic leukemia. Further, they have important functions in embryonic development. Hence, identification and characterization of membe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f657c9ef0b5d808fbfc791e271c7b29
https://doi.org/10.1038/sj.onc.1201427
https://doi.org/10.1038/sj.onc.1201427
Publikováno v:
Oncogene. 14:2845-2855
Activation of helper T cells results in coordinate expression of a number of cytokines involved in differentiation, proliferation and activation of the haematopoietic system. Granulocyte-macrophage colony stimulating factor (GM-CSF) is one such cytok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d657731b84b6353e2433ea23ca30154
https://doi.org/10.1038/sj.onc.1201125
https://doi.org/10.1038/sj.onc.1201125
Autor:
Dm Thompson, A Panayiotakis, Robert G. Ramsay, R Ascione, Ismail Kola, Ross S Thomas, Martin J. Tymms, A Seth
Publikováno v:
International journal of oncology. 1(6)
The Ets family of genes encode nuclear proteins that activate transcription by binding to a specific purine-rich (GGAA) ets binding sequence (EBS) present in promoters/enhancers of various genes. We have previously shown that over-expression of ets1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7a865ece2d21a2b2161d19e867414f
https://pubmed.ncbi.nlm.nih.gov/21584592
https://pubmed.ncbi.nlm.nih.gov/21584592
Autor:
Laki Buluwela, Andrew Photiou, Chun-Fui Lai, R. Charles Coombes, Paul Thiruchelvam, Eric A. Ortlund, Hui Hua, Simak Ali, Alan C. Spivey, Richard J. Whitby, Ross S. Thomas, Andrew R. Bayly, Manikandan Periyasamy, Fiona Kyle, Jason S. Carroll, William H. Hudson, Antoni Hurtado
Publikováno v:
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2010, 127 (2), pp.385-396. ⟨10.1007/s10549-010-0994-9⟩
Breast Cancer Research and Treatment, Springer Verlag, 2010, 127 (2), pp.385-396. ⟨10.1007/s10549-010-0994-9⟩
International audience; Estrogen receptor-α (ER) is expressed in the great majority of breast cancers, and the inhibition of ER action is a key part of breast cancer treatment. The inhibition of ER action is achieved using anti-estrogens, primarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ba029f1036211066007ad86f83aa6b
https://hal.archives-ouvertes.fr/hal-00594480/file/PEER_stage2_10.1007%2Fs10549-010-0994-9.pdf
https://hal.archives-ouvertes.fr/hal-00594480/file/PEER_stage2_10.1007%2Fs10549-010-0994-9.pdf
Autor:
Andrew Photiou, Simak Ali, Chun-Fui Lai, Marwa Al-Sabbagh, Rosemary A. Fisher, R. Charles Coombes, Manikandan Periyasamy, Laki Buluwela, Robert S. Tolhurst, Lesley-Ann Martin, Sayka Barry, Paul Thiruchelvam, Tahereh Kamalati, Mitch Dowsett, Hetal Patel, Tatjana Crnogorac-Jurcevic, Fiona Kyle, Ross S. Thomas
Publikováno v:
Breast cancer research and treatment. 128(2)
Estrogen receptor-α (ERα) positive breast cancer frequently responds to inhibitors of ERα activity, such as tamoxifen, and/or to aromatase inhibitors that block estrogen biosynthesis. However, many patients become resistant to these agents through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484150187b6ed5d9ba721fd0cc10462e
https://pubmed.ncbi.nlm.nih.gov/20730598
https://pubmed.ncbi.nlm.nih.gov/20730598
Autor:
Noel C. Wortham, Susan E. Bray, R. C. Coombes, Les Huson, Samantha M. Nicol, Frances V. Fuller-Pace, Ross S. Thomas, Manikandan Periyasamy, Jie Jiang, E Ahamed, Anna Maria Ochocka, Simak Ali, Sami Shousha
Publikováno v:
Oncogene
The DEAD-box RNA helicases p68 (DDX5) and p72 (DDX17) have been shown to act as transcriptional co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ERalpha). Here, we show that, although both proteins inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab1e0322520a1baf3e3abf10e37974d
https://pubmed.ncbi.nlm.nih.gov/19718048
https://pubmed.ncbi.nlm.nih.gov/19718048