Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Ross Laybutt"'
Autor:
Indu G. Rajapaksha, Lakmie S. Gunarathne, Khashayar Asadi, Ross Laybutt, Sof Andrikopoulous, Ian E. Alexander, Mathew J. Watt, Peter W. Angus, Chandana B. Herath
Publikováno v:
Hepatology Communications, Vol 6, Iss 5, Pp 1056-1072 (2022)
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is frequently associated with type 2 diabetes. However, there is no specific medical therapy to treat this condition. Angiotensin‐converting enzyme 2 (AC
Externí odkaz:
https://doaj.org/article/08064fce3b5743cb8a28721cf571fa86
Autor:
Nicola J. Lee, Amy D. Nguyen, Ronaldo F. Enriquez, Jude Luzuriaga, Mohammed Bensellam, Ross Laybutt, Paul A. Baldock, Herbert Herzog
Publikováno v:
Molecular Metabolism, Vol 4, Iss 3, Pp 164-174 (2015)
Objective: The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear. Methods: Here we employ mice lacking neuropeptide Y, Y1 receptors solely in cells o
Externí odkaz:
https://doaj.org/article/6408bae3d0e7442588fe06bc2bb6da23
Publikováno v:
Nutrition, Metabolism and Cardiovascular Diseases. 32:2439-2449
Betaine supplementation has been shown to enhance hepatic lipid metabolism in obese mice and improve exercise performance in healthy populations. We examined effects of betaine supplementation, alone or in combination with treadmill exercise, on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df418d8579e71a0b6b004ae93acae96
https://doi.org/10.1016/j.numecd.2022.08.012
https://doi.org/10.1016/j.numecd.2022.08.012
Autor:
Mojgan Nazari, Kenneth W. Ho, Natasha Langley, Kuan M. Cha, Raymond Kodsi, Mawson Wang, D. Ross Laybutt, Kim Cheng, Rebecca A. Stokes, Michael M. Swarbrick, Jenny E. Gunton
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown adipose tissue (BAT) may increase total daily energy expenditure by 20%. Humans normally have more beige an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a201e1be1409d397095ee36f740f8777
https://doi.org/10.1038/s41598-022-04809-8
https://doi.org/10.1038/s41598-022-04809-8
Autor:
Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G. Pappas, Xin Liu, John W. Scott, Jonathan S. Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L. Eizirik, D. Ross Laybutt, Herbert Herzog, Helen E. Thomas, Kim Loh
Publikováno v:
Molecular Metabolism, Vol 55, Iss, Pp 101413-(2022)
Molecular Metabolism
Molecular Metabolism
Objectives Loss of functional β-cell mass is a key factor contributing to poor glycemic control in advanced type 2 diabetes (T2D). We have previously reported that the inhibition of the neuropeptide Y1 receptor improves the islet transplantation out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a7ecdfaccc807908090a8a1ce8c978
http://www.sciencedirect.com/science/article/pii/S2212877821002714
http://www.sciencedirect.com/science/article/pii/S2212877821002714
Autor:
Indu G. Rajapaksha, Lakmie S. Gunarathne, Khashayar Asadi, Ross Laybutt, Sof Andrikopoulous, Ian E. Alexander, Mathew J. Watt, Peter W. Angus, Chandana B. Herath
Publikováno v:
Hepatology communications. 6(5)
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is frequently associated with type 2 diabetes. However, there is no specific medical therapy to treat this condition. Angiotensin-converting enzyme 2 (ACE2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6005c1a920b3819702db5dc77335d8df
https://pubmed.ncbi.nlm.nih.gov/34951153
https://pubmed.ncbi.nlm.nih.gov/34951153
Autor:
Jee-Hye Kim, Viviane Delghingaro-Augusto, Jeng Yie Chan, D. Ross Laybutt, Joseph Proietto, Christopher J. Nolan
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2022)
Frontiers in Endocrinology, Vol 12 (2022)
BackgroundMaintenance of a normal fetal nutrient supply requires major adaptations in maternal metabolic physiology, including of the islet beta-cell. The role of lipid signaling processes in the mechanisms of islet beta-cell adaptation to pregnancy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeb596c72bd84e55dfd1881d0b15462
https://pubmed.ncbi.nlm.nih.gov/35069446
https://pubmed.ncbi.nlm.nih.gov/35069446
Autor:
Kailun Lee, Jeng Yie Chan, Cassandra Liang, Chi Kin Ip, Yan-Chuan Shi, Herbert Herzog, William E. Hughes, Mohammed Bensellam, Viviane Delghingaro-Augusto, Mark E. Koina, Christopher J. Nolan, D. Ross Laybutt
Publikováno v:
Diabetologia. 65(6)
Aims/hypothesis Pancreatic beta cell dedifferentiation, transdifferentiation into other islet cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the mechanisms are poorly defined. The endoplasmic reticulum stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4babfa5b1526a415f0d3684eddcae52d
https://pubmed.ncbi.nlm.nih.gov/35316840
https://pubmed.ncbi.nlm.nih.gov/35316840
Publikováno v:
Diabetologia. 62:993-999
Mild islet inflammation has been suggested as a contributing factor to beta cell failure in type 2 diabetes. Macrophage levels are elevated in the islets of humans and mice with type 2 diabetes, but their effects on beta cells are not understood. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af27124a992c990d3c130ff7f4be7e5e
https://doi.org/10.1007/s00125-019-4844-y
https://doi.org/10.1007/s00125-019-4844-y
Autor:
Xuzhu Lin, Kim Loh, Alba Moreno-Asso, Chieh Hsin Yang, Ross Laybutt, Herbert Herzog, John W. Scott, Cassandra Smith, Stacey Fynch, Decio L. Eizirik, Liu X, Helen E. Thomas, Jonathan S. Oakhill, Evan Pappas, Nadarajah S, Yan-Chuan Shi, Sandra Galic, Loudovaris T, Itamar Levinger, Ann-Onda D
Loss of functional β-cell mass is a key factor contributing to the poor glycaemic control in type 2 diabetes. However, therapies that directly target these underlying processes remains lacking. Here we demonstrate that gene expression of neuropeptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10896846473d66d95c2bf652d57d9527
https://doi.org/10.1101/2021.05.14.444149
https://doi.org/10.1101/2021.05.14.444149
