Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Ross Laman"'
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A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy
Autor: Claire Stevens, Jody Clements, Katy Hills, Ross Laman, Jennifer E. Roy, David S. Richardson, Jennifer Cole, Sarah Edkins, Christopher Greenman, Kelly Halliday, Sofie West, Helen Davies, Matthew Gorton, Sara Widaa, Richard Wooster, Adam Butler, Richard Lugg, Raffaella Smith, Tracy T. Batchelor, Lisa Brackenbury, Jon W. Teague, Gregory J. Riggins, Andy Jenkinson, Adrian Parker, Syd Barthorpe, Christopher I. Hunter, Simon A. Forbes, Michael R. Stratton, Wolf Mueller, Douglas F. Easton, Janet Perry, Jennifer Varian, Sarah O’Meara, David N. Louis, Helen Solomon, David T. Jones, Ed Dicks, Rachel Harrison, P. Andrew Futreal, Rebecca Shepherd, Philip J. Stephens, Keiran Raine, Tim Avis, Kristian Gray, Gemma Buck, Daniel P. Cahill, Andrew D. Yates, Vivienne Kosmidou, Jonathon Hinton, Robert Petty, Andrew Menzies, Graham R. Bignell, Calli Tofts, Alexandra Small, Kymberly K. Levine
Publikováno v: Cancer Res
Malignant gliomas have a very poor prognosis. The current standard of care for these cancers consists of extended adjuvant treatment with the alkylating agent temozolomide after surgical resection and radiotherapy. Although a statistically significan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa969034dc593f7ea0e864ded4c8df4
https://europepmc.org/articles/PMC7212022/
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6
Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults
Autor: J. Wolter Oosterhuis, Tim Avis, Gemma Buck, Ruud J.H.L.M. van Gurp, Michael R. Stratton, Simon A. Forbes, Richard Wooster, Kelly Halliday, Adam Butler, Raffaella Smith, Philip J. Stephens, Lisa Brackenbury, Jody Clements, Jon W. Teague, Jennifer Cole, Sarah Edkins, Anthony Webb, Katy Hills, Helen Davies, Yvonne Stephens, Keiran Raine, Ed Dicks, Sara Widaa, Claire Stevens, Adrian Parker, Sarah O’Meara, Christopher Greenman, Ross Laman, Christopher I. Hunter, Syd Barthorpe, P. Andrew Futreal, Leendert H. J. Looijenga, Ken Edwards, Rachel Harrison, Rebecca Shepherd, Helen Solomon, Andrew D. Yates, David T. Jones, Kristian Gray, Sofie West, Matthew Gorton, Robert Petty, Andrew Menzies, Ad J. M. Gillis, Vivienne Kosmidou, Janet Perry, Alexandra Small, Jennifer Varian, Jonathon Hinton, Calli Tofts, Graham R. Bignell, Hans Stoop, Richard Lugg
Publikováno v: Genes Chromosomes & Cancer, 45, 42-46. Wiley-Liss Inc.
Genes Chromosomes Cancer
The protein kinase gene family is the most frequently mutated in human cancer. Previous work has documented activating mutations in the KIT receptor tyrosine kinase in testicular germ-cell tumors (TGCT). To investigate further the potential role of m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3630a8946fdb34594ed2e0ffa8b95c
https://pure.eur.nl/en/publications/4a08d5f7-ce0c-4fcd-afc7-8c186385ab34
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7
Somatic mutations of the protein kinase gene family in human lung cancer
Autor: Adrienne M. Flanagan, Graham R. Bignell, Jennifer Cole, Adam Butler, Douglas F. Easton, Janet Perry, Helen Davies, Anthony R. Green, Bin Tean Teh, Bruce Malkowicz, Andrew G. Nicholson, Raffaella Smith, Jon W. Teague, Jennifer Varian, Peter Goldstraw, Rachel Harrison, Suet Yi Leung, Alexandra Small, Ken Edwards, Sunil R. Lakhani, Andrew D. Yates, Ed Dicks, Gemma Buck, Rebecca Shepherd, Simon A. Forbes, Sofie West, Keiran Raine, Claire Stevens, Sara Widaa, Richard Wooster, Sarah O’Meara, Kristian Gray, Barbara L. Weber, Sarah Edkins, Kelly Halliday, Philip J. Stephens, Christopher Greenman, Tim Avis, Marco A. Pierotti, P. Andrew Futreal, Richard Lugg, Jody Clements, Anthony Webb, Siu Tsan Yuen, Katy Hills, Helen Solomon, Colin Cooper, Francis Brasseur, Ross Laman, Lisa Brackenbury, Calli Tofts, Jonathon Hinton, Yvonne Stephens, David Jones, Michael R. Stratton, Robert Petty, Andrew Menzies, Maggie Knowles, Syd Barthorpe, Matthew Gorton, Vivienne Kosmidou, Adrian Parker, Christopher I. Hunter, Leendert H. J. Looijenga
Publikováno v: Cancer Research, 65(17), 7591-7595. American Association for Cancer Research Inc.
Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. We screened the coding sequences of 518 protein kinases (∼1.3 Mb of DNA per sample) for somatic mutations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5446c6ac87aec9a988f52a5ac5286ead
https://pubmed.ncbi.nlm.nih.gov/16140923
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8
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Autor: Adrienne M. Flanagan, Bin Teh, Calli Tofts, Simon A. Forbes, Christopher Greenman, Richard Wooster, Keiran Raine, Jonathon Hinton, Bruce Malkowicz, Ken Edwards, Alexandra Small, Sarah O’Meara, Kelly Halliday, Colin Cooper, Francis Brasseur, Andrew D. Yates, Graham R. Bignell, Andy Barthorpe, Sofie West, Robert Petty, Michael R. Stratton, Sara Widaa, Andrew Menzies, Philip J. Stephens, Matthew Gorton, Sunil R. Lakhani, Ed Dicks, Janet Perry, Jody Clements, Yvonne Stephens, Adam Butler, Maggie Knowles, Anthony R. Green, Charles Cox, Kristian Gray, Richard Lugg, Jennifer Varian, Katy Hills, Jon W. Teague, Tim Avis, Douglas F. Easton, Andrew G. Nicholson, Siu Tsan Yuen, Raffaella Smith, Patrick S. Tarpey, Claire Stevens, Helen Solomon, Rachel Harrison, Suet Yi Leung, David T. Jones, Rebecca Shepherd, Barbara L. Weber, Marco A. Pierotti, Vivienne Kosmidou, Anthony Webb, P. Andrew Futreal, Jennifer Cole, Sarah Edkins, Helen Davies, Ross Laman, Adrian Parker, Christopher I. Hunter, Leendert H. J. Looijenga, Gemma Buck, Lisa Brackenbury
Publikováno v: Nature Genetics, 37(6), 590-592. Nature Publishing Group
We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b23c22bcb97cd0ef64f25e6b7bc7565
https://pure.eur.nl/en/publications/6502e7d9-a9ba-4103-b4b6-1ad476656d7c
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