Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ross L. Blankenship"'
Autor:
Anjul Khadria, Chad D. Paavola, Konstantin Maslov, Francisco A. Valenzuela, Andrea E. Sperry, Amy L. Cox, Rui Cao, Junhui Shi, Patricia L. Brown-Augsburger, Emmanuel Lozano, Ross L. Blankenship, Ranajoy Majumdar, Scott A. Bradley, John M. Beals, Sunday S. Oladipupo, Lihong V. Wang
Publikováno v:
Molecular Metabolism, Vol 62, Iss , Pp 101522- (2022)
Objective: Ultra-rapid insulin formulations control postprandial hyperglycemia; however, inadequate understanding of injection site absorption mechanisms is limiting further advancement. We used photoacoustic imaging to investigate the injection site
Externí odkaz:
https://doaj.org/article/4e686fb7d1214da195f3ad2aa1b7871d
Autor:
Anjul Khadria, Chad D. Paavola, Konstantin Maslov, Patricia L. Brown-Augsburger, Patrick F. Grealish, Emmanuel Lozano, Ross L. Blankenship, Rui Cao, Junhui Shi, John M. Beals, Sunday S Oladipupo, Lihong V. Wang
Over 100 monoclonal antibodies have been approved by the FDA for clinical use; however, a paucity of knowledge exists regarding the injection site behavior of these formulated therapeutics, i.e., the effect of antibody and formulation on the tissue a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a84a060b67bf2dc067a9d8eada60bc4
https://doi.org/10.1101/2022.09.29.509334
https://doi.org/10.1101/2022.09.29.509334
Autor:
Zheng Yu Wang, Jessica B. Montgomery, Jose L. Estrada, A. Joseph Tector, Ross L. Blankenship, Ping Li, Matthew Tector, Shunji Nagai, Susan M. Downey, James R. Butler
Publikováno v:
Transplantation. 100:533-537
BACKGROUND Disrupting the porcine GGTA1 and CMAH genes [double knockout (DKO)] that produce the gal-α(1,3)-gal and N-glycolylneuraminic acid xenoantigens reduces human antibody binding to porcine peripheral blood mononuclear cells. It is important t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af21fb60423c3c883f70fc2411565ab
https://doi.org/10.1097/tp.0000000000001070
https://doi.org/10.1097/tp.0000000000001070
Autor:
Matthew Tector, Gregory R. Martens, Leela L. Paris, James R. Butler, Ping Li, Ross L. Blankenship, Richard A. Sidner, Jose L. Estrada, A. Joseph Tector, Joseph M. Ladowski
Publikováno v:
Transplantation. 100:571-576
A profound thrombocytopenia limits hepatic xenotransplantation in the pig-to-primate model. Porcine livers also have shown the ability to phagocytose human platelets in the absence of immune-mediated injury. Recently, inactivation of the porcine ASGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdd7c11fa91ba22eeb3bbeadb2eee85
https://doi.org/10.1097/tp.0000000000001071
https://doi.org/10.1097/tp.0000000000001071
Autor:
Matthew Tector, Leela L. Paris, Ross L. Blankenship, A. J. Tector, Luz M. Reyes, Aaron C. Miner, Rachel J. Blosser, Rashod F. Smith
Publikováno v:
Tissue Antigens. 84:484-488
We have characterized swine leucocyte antigen (SLA) classes I and II molecules of a domestic pig as a model for use in our xenotransplant program. Molecular characterization of the SLA classes I and II genes is critical to understanding the adaptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401b11f76f28b48c66b49ad6e51d4cd2
https://doi.org/10.1111/tan.12430
https://doi.org/10.1111/tan.12430
Autor:
A. Joseph Tector, Leela L. Paris, Christopher Burlak, Bess Ivary, Ping Li, Ray K. Chihara, Luz M. Reyes, R A Sidner, Ross L. Blankenship, Susan M. Downey, Jose L. Estrada, Fuqin Yin, Zheng-Yu Wang, Andrew J. Lutz
Publikováno v:
Xenotransplantation. 20:27-35
Background Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells. Galα-1,3-Gal (Gal) and N-glycolylneuraminic acid (Neu5Gc) are two known xenoantigens. Methods We report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695a5f4c317e81cdfdc314f836a6b442
https://doi.org/10.1111/xen.12019
https://doi.org/10.1111/xen.12019
Autor:
Richard A. Sidner, Ross L. Blankenship, A. Joseph Tector, Zheng Yu Wang, Ping Li, Gregory R. Martens, Matthew Tector, Jose L. Estrada
Publikováno v:
Transplantation. 101(3)
Background The rapidly improving tools of genetic engineering may make it possible to overcome the humoral immune barrier that prevents xenotransplantation. We hypothesize that levels of human antibody binding to donor tissues from swine must approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edafd67a3c900ceb55319ba6c9f2353
https://pubmed.ncbi.nlm.nih.gov/27379553
https://pubmed.ncbi.nlm.nih.gov/27379553
Autor:
Jose L. Estrada, Leela L. Paris, Zheng Yu Wang, James R. Butler, Ping Li, Christopher Burlak, Richard A. Sidner, Susan M. Downey, Jessica B. Montgomery, Luz M. Reyes, A. Joseph Tector, Matthew Tector, Ross L. Blankenship
Publikováno v:
Xenotransplantation. 22(3)
Background The lethal thrombocytopenia that accompanies liver xenotransplantation is a barrier to clinical application. Human platelets are bound by the asialoglycoprotein receptor (ASGR) on pig sinusoidal endothelial cells and phagocytosed. Inactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d8a120de35acad85e44595522ec3a7
https://pubmed.ncbi.nlm.nih.gov/25728617
https://pubmed.ncbi.nlm.nih.gov/25728617
Autor:
Leela L. Paris, James R. Butler, Jose L. Estrada, A. Joseph Tector, Jessica B. Montgomery, Zheng Yu Wang, Susan M. Downey, Ross L. Blankenship, Ping Li, Rafael Miyashiro Nunes dos Santos, Christopher Burlak, Matthew Tector
Publikováno v:
Xenotransplantation. 22(1)
Background Manipulating the pig genome to increase compatibility with human biology may facilitate the clinical application of xenotransplantation. Genetic modifications to pig cells have been made by sequential recombination in fetal fibroblasts and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c28b362a3e0a070ad6d79ec944743ce
https://pubmed.ncbi.nlm.nih.gov/25178170
https://pubmed.ncbi.nlm.nih.gov/25178170
Autor:
Jose Estrada, R A Sidner, Susan M. Downey, Matthew Tector, James R. Butler, Leela L. Paris, Ross L. Blankenship, A. J. Tector
Publikováno v:
Transplantation. 98:415-416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ea5f80ede49b74df755fd4e176ca5c
https://doi.org/10.1097/00007890-201407151-01375
https://doi.org/10.1097/00007890-201407151-01375