Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Ross L Cagan"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010792 (2023)
Experimental models that capture the genetic complexity of human disease and allow mechanistic explorations of the underlying cell, tissue, and organ interactions are crucial to furthering our understanding of disease biology. Such models require com
Externí odkaz:
https://doaj.org/article/343a5a5b8eaf49e7909fd1976bc95854
Autor:
Peter M U Ung, Masahiro Sonoshita, Alex P Scopton, Arvin C Dar, Ross L Cagan, Avner Schlessinger
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006878 (2019)
Drosophila provides an inexpensive and quantitative platform for measuring whole animal drug response. A complementary approach is virtual screening, where chemical libraries can be efficiently screened against protein target(s). Here, we present a u
Externí odkaz:
https://doaj.org/article/314c6675ac5d4158a1dd1b291006b7e2
Autor:
Susumu Hirabayashi, Ross L Cagan
Publikováno v:
eLife, Vol 4 (2015)
Cancer cells demand excessive nutrients to support their proliferation but how cancer cells sense and promote growth in the nutrient favorable conditions remain incompletely understood. Epidemiological studies have indicated that obesity is a risk fa
Externí odkaz:
https://doaj.org/article/0b55e1549c7e49af9e45a839d6a8b6d0
Publikováno v:
PLoS Computational Biology, Vol 6, p e1000841 (2010)
We present a computer simulation and associated experimental validation of assembly of glial-like support cells into the interweaving hexagonal lattice that spans the Drosophila pupal eye. This process of cell movements organizes the ommatidial array
Externí odkaz:
https://doaj.org/article/7513861bc38845cda7f26d01cc3b3ed0
Autor:
Ruth I Johnson, Ross L Cagan
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7008 (2009)
BACKGROUND:The Drosophila pupal eye has become a popular paradigm for understanding morphogenesis and tissue patterning. Correct rearrangement of cells between ommatidia is required to organize the ommatidial array across the eye field. This requires
Externí odkaz:
https://doaj.org/article/13b3b2fbe9314b80b0f65df7b895460e
A key tool of cancer therapy has been targeted inhibition of oncogene-addicted pathways. However, efficacy has been limited by progressive emergence of resistance as transformed cells adapt. Here, we use Drosophila to dissect response to targeted the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3680f73d54dd03cfdcd4f16ee010cfd6
https://doi.org/10.1158/0008-5472.c.6508046.v1
https://doi.org/10.1158/0008-5472.c.6508046.v1
Figure S7, S8, shows effect of sorafenib/bortezomib/vorinostat on TT cell tumor xenografts in mice and effect of 'network brake' drug combinations on different human cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e5912985b823c16413d7ebbaad5e28
https://doi.org/10.1158/0008-5472.22410674.v1
https://doi.org/10.1158/0008-5472.22410674.v1
Shows statistics for drug screen in flies and CI index in human cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2344c4d0b4138cf64fed1760f3487239
https://doi.org/10.1158/0008-5472.22410668.v1
https://doi.org/10.1158/0008-5472.22410668.v1
Supplementary Figure 2 from Differing Src Signaling Levels Have Distinct Outcomes in Drosophila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5052cf746b5e2191ec0603d38aa962
https://doi.org/10.1158/0008-5472.22371113.v1
https://doi.org/10.1158/0008-5472.22371113.v1
Supplementary Figure 3 from Differing Src Signaling Levels Have Distinct Outcomes in Drosophila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a505b826784d50dfbd412efb3a23d496
https://doi.org/10.1158/0008-5472.22371110
https://doi.org/10.1158/0008-5472.22371110