Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Ross L Cagan"'
Autor:
Jennifer E. L. Diaz, Vanessa Barcessat, Christian Bahamon, Chana Hecht, Tirtha K. Das, Ross L. Cagan
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/e0b3d58cd64b4977bc6f17c8fdf46280
Autor:
Bojie Cong, Ross L. Cagan
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-7 (2024)
Abstract Throughout an individual’s life, somatic cells acquire cancer-associated mutations. A fraction of these mutations trigger tumour formation, a phenomenon partly driven by the interplay of mutant and wild-type cell clones competing for domin
Externí odkaz:
https://doaj.org/article/a6886b5b019040ac83ce4ce6c1a3af27
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010792 (2023)
Experimental models that capture the genetic complexity of human disease and allow mechanistic explorations of the underlying cell, tissue, and organ interactions are crucial to furthering our understanding of disease biology. Such models require com
Externí odkaz:
https://doaj.org/article/343a5a5b8eaf49e7909fd1976bc95854
Autor:
Mojgan Padash Barmchi, Miranda Thomas, Jayashree V. Thatte, Arushi Vats, Bing Zhang, Ross L. Cagan, Lawrence Banks
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Human papillomavirus (HPV) is the leading cause of cervical cancer and has been implicated in several other cancer types including vaginal, vulvar, penile, and oropharyngeal cancers. Despite the recent availability of a vaccine, there are st
Externí odkaz:
https://doaj.org/article/7444da68b90b44009b1780a02e5e7108
Autor:
Erdem Bangi, Peter Smibert, Andrew V. Uzilov, Alexander G. Teague, Sindhura Gopinath, Yevgeniy Antipin, Rong Chen, Chana Hecht, Nelson Gruszczynski, Wesley J. Yon, Denis Malyshev, Denise Laspina, Isaiah Selkridge, Huan Wang, Jorge Gomez, John Mascarenhas, Aye S. Moe, Chun Yee Lau, Patricia Taik, Chetanya Pandya, Max Sung, Sara Kim, Kendra Yum, Robert Sebra, Michael Donovan, Krzysztof Misiukiewicz, Celina Ang, Eric E. Schadt, Marshall R. Posner, Ross L. Cagan
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102212- (2021)
Summary: Adenoid cystic carcinoma (ACC) is a rare cancer type that originates in the salivary glands. Tumors commonly invade along nerve tracks in the head and neck, making surgery challenging. Follow-up treatments for recurrence or metastasis includ
Externí odkaz:
https://doaj.org/article/a515dc8776494774a7791cde6351eadf
Autor:
Peter M U Ung, Masahiro Sonoshita, Alex P Scopton, Arvin C Dar, Ross L Cagan, Avner Schlessinger
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006878 (2019)
Drosophila provides an inexpensive and quantitative platform for measuring whole animal drug response. A complementary approach is virtual screening, where chemical libraries can be efficiently screened against protein target(s). Here, we present a u
Externí odkaz:
https://doaj.org/article/314c6675ac5d4158a1dd1b291006b7e2
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Colorectal cancers carry multiple mutations. Here, the authors use Drosophilaas a model organism and assess multiple combinations of mutations and their response to various drugs, providing further insight into drug resistance mechanisms.
Externí odkaz:
https://doaj.org/article/e59e5a0467fd4abfb5f65e06e4a7d710
Autor:
Sarah Levinson, Ross L. Cagan
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 3052-3061 (2016)
We generated and compared Drosophila models of RET fusions CCDC6-RET and NCOA4-RET. Both RET fusions directed cells to migrate, delaminate, and undergo EMT, and both resulted in lethality when broadly expressed. In all phenotypes examined, NCOA4-RET
Externí odkaz:
https://doaj.org/article/88fb2a2d36f44ccea275a2eea4819511
Autor:
Benjamin D. Levine, Ross L. Cagan
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1477-1487 (2016)
We have developed a Drosophila lung cancer model by targeting Ras1G12V—alone or in combination with PTEN knockdown—to the Drosophila tracheal system. This led to overproliferation of tracheal tissue, formation of tumor-like growths, and animal le
Externí odkaz:
https://doaj.org/article/f557198148f04bfca7a82277f5091329
A key tool of cancer therapy has been targeted inhibition of oncogene-addicted pathways. However, efficacy has been limited by progressive emergence of resistance as transformed cells adapt. Here, we use Drosophila to dissect response to targeted the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3680f73d54dd03cfdcd4f16ee010cfd6
https://doi.org/10.1158/0008-5472.c.6508046.v1
https://doi.org/10.1158/0008-5472.c.6508046.v1
