Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ross Kettleborough"'
Autor:
William M. Shaw, Ross Kettleborough, Tom Ellis, David Öling, Niklas Larsson, Mark Wigglesworth, Sonya Clark, Lina Lawenius
Publikováno v:
ACS Synthetic Biology. 7:2317-2321
Site saturation mutagenesis (SSM) is a powerful mutagenesis strategy for protein engineering and directed evolution experiments. However, limiting factors using this method are either biased representation of variants, or limiting library size. To ov
Autor:
Ross Kettleborough, Catherine M Scahill, Derek L. Stemple, Fruzsina Fényes, Elisabeth M. Busch-Nentwich, Christopher M. Dooley
Publikováno v:
Methods (San Diego, Calif.)
The zebrafish mutation project (ZMP) aims to generate a loss of function allele for every protein-coding gene, but importantly to also characterise the phenotypes of these alleles during the first five days of development. Such a large-scale screen r
Autor:
Jeffrey A. Yoder, Derek L. Stemple, Jorge Andrade, Kyle M. Hernandez, Ross Kettleborough, Dustin J. Wcisel, Jill L. O. de Jong, Sean C. McConnell
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Antigen processing and presentation genes found within the MHC are among the most highly polymorphic genes of vertebrate genomes, providing populations with diverse immune responses to a wide array of pathogens. Here, we describe transcriptome, exome
Autor:
Samantha Carruthers, Elisabeth M. Busch-Nentwich, Isabel Brocal, Richard Clark, Amanda Hall, Christopher M. Dooley, Derek L. Stemple, Ross Kettleborough, Richard White
Publikováno v:
BMC Genomics
Background The CRISPR/Cas9 system is a prokaryotic immune system that infers resistance to foreign genetic material and is a sort of 'adaptive immunity'. It has been adapted to enable high throughput genome editing and has revolutionised the generati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8d0b0233c9dda5ca60a817633a848c
https://zenodo.org/record/58796
https://zenodo.org/record/58796
Autor:
Ross Kettleborough, Makoto Kamei, Annabelle Scott, Kevin A. Thomas, Moon Kyoung Bae, Derek L. Stemple, Michael J. Parsons, Van N. Pham, Brant M. Weinstein, Steven M. Pollard
Publikováno v:
Developmental Biology. 289:64-76
Laminins are major constituents of basement membranes and have wide ranging functions during development and in the adult. They are a family of heterotrimeric molecules created through association of an alpha, beta and gamma chain. We previously repo
Autor:
Sean M. Grimmond, James C. Smith, Joshua M. Brickman, Rosa S.P. Beddington, Alistair R. R. Forrest, Melanie Clements, Amer Ahmed Rana, Sally L. Dunwoodie, Rita Sousa-Nunes, Ross Kettleborough, Philip Avner
Publikováno v:
Genome Research. 13:2609-2620
This article investigates the expression patterns of 160 genes that are expressed during early mouse development. The cDNAs were isolated from 7.5 d postcoitum (dpc) endoderm, a region that comprises visceral endoderm (VE), definitive endoderm, and t
Autor:
Steven A. Harvey, Derek L. Stemple, Fruzsina Fényes, Ross Kettleborough, Richard White, Ian M Sealy, James C. Smith
Publikováno v:
Development (Cambridge, England)
Transcription is an essential component of basic cellular and developmental processes. However, early embryonic development occurs in the absence of transcription and instead relies upon maternal mRNAs and proteins deposited in the egg during oocyte
Autor:
Richard Gibbons, Samantha Carruthers, Elisabeth M. Busch-Nentwich, Neha Wali, Richard White, Catherine M Scahill, Derek L. Stemple, Isaac J. Nijman, Ewart de Bruijn, Steven A. Harvey, Jennifer Yen, Selina Mehroke, Christopher M. Dooley, Ross Kettleborough, Edwin Cuppen, Colin Herd, Freek van Eeden, Fruzsina Fényes, Ian M Sealy, Amanda Hall
Publikováno v:
Nature, 496(7446), 494-497. Nature Publishing Group
Nature
Nature
Since the publication of the human reference genome, the identities of specific genes associated with human diseases are being discovered at a rapid rate. A central problem is that the biological activity of these genes is often unclear. Detailed inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a039e315928d2d323068ee593bbac219
https://pure.knaw.nl/portal/en/publications/609cc023-9032-4a83-8b41-d550aea36368
https://pure.knaw.nl/portal/en/publications/609cc023-9032-4a83-8b41-d550aea36368
Autor:
Augusto Rendon, Ana Cvejic, Paquita Nurden, Peter A. Smethurst, Ross Kettleborough, Randy J. Read, Willem H. Ouwehand, Katrin Voss, Rémi Favier, Graham Kiddle, Paul Bertone, Marie-Christine Alessi, Myrto Kostadima, Botond Sipos, Cornelis A. Albers, Alan T. Nurden, Evelien E. Bouwmans, Gregory E. Jordan, Jonathan Stephens, Suthesh Sivapalaratnam
Publikováno v:
Nature genetics, 43(8), 735-737. Nature Publishing Group
Nature genetics
Nature genetics
Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is characterized by mild thrombocytopenia with large platelets and a paucity of α-granules; these abnormalities cause mostly moderate but in rare cases severe bleeding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abc58bd4c63583725787a8614ccc3d5
https://www.repository.cam.ac.uk/handle/1810/309463
https://www.repository.cam.ac.uk/handle/1810/309463
There is an increasing requirement for efficient reverse genetics in the zebrafish, Here we describe a method that takes advantage of conventional mutagenized libraries (identical to ones used in forward screens) and re-sequencing to identify ENU-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe42c498ef8e1c8b15131fded0cc4413
https://doi.org/10.1016/b978-0-12-374814-0.00006-9
https://doi.org/10.1016/b978-0-12-374814-0.00006-9