Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ross James Macrae"'
Autor:
Valerie Hoffart, Nantharat Pearnchob, Roland Bodmeier, Mathias Walther, Mesut Ciper, Martin Körber, Ross James Macrae
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 78:447-454
Weakly basic drugs and their salts exhibit a decrease in aqueous solubility at higher pH, which can result in pH-dependent or even incomplete release of these drugs from extended release formulations. The objective of this study was to evaluate strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e07cebc94dc2b822a5f3d067f158c
https://doi.org/10.1016/j.ejpb.2011.03.018
https://doi.org/10.1016/j.ejpb.2011.03.018
Publikováno v:
Journal of Controlled Release. 125:1-15
The use of polymer blends as coating materials for controlled drug delivery systems can offer major advantages, including: (i) facilitated adjustment of desired drug release patterns, mechanical properties and drug release mechanisms, (ii) improved f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46daa108c2f0363a6f6256c396ee252c
https://doi.org/10.1016/j.jconrel.2007.09.012
https://doi.org/10.1016/j.jconrel.2007.09.012
Autor:
Ross James Macrae, Janet S. Burton, Craig S. Foster, Steve W. Doughty, Colin D. Melia, J. Craig Richardson
Publikováno v:
Carbohydrate Polymers. 65:22-27
The influence of molecular structure of small ionised molecules on the thermo-reversible sol:gel phase transition of a hydroxyalkyl cellulose ether has been investigated with respect to an l -amino acid series. The concentration dependency of the pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7acb955f8e4e94b47e4a7b7495fdc42
https://doi.org/10.1016/j.carbpol.2005.11.022
https://doi.org/10.1016/j.carbpol.2005.11.022
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 60:73-80
The effect of SBE7-beta-cyclodextrin together with hydroxypropylmethyl cellulose (HPMC) or polyvinylpyrrolidone (PVP) on the saturated solubility and delivery of carbamazepine (a poorly soluble drug) from sustained release (SR) beads was investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bc2682ee90889b2dcf484f6ca2ba4f
https://doi.org/10.1016/j.ejpb.2004.12.001
https://doi.org/10.1016/j.ejpb.2004.12.001
Publikováno v:
Biomacromolecules. 6:2074-2083
The aim of this study was to coat theophylline-loaded spherical beads with pH-sensitive polymer blends to control the resulting drug release kinetics. Various mixtures of ethylcellulose (water-insoluble) and Eudragit L (methacrylic-acid-ethyl-acrylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7247aa7cb07852ecfcf4f61ce3819892
https://doi.org/10.1021/bm0500704
https://doi.org/10.1021/bm0500704
Autor:
Jonathan C.D Sutch, Richard Bowtell, Colin D. Melia, Howard N.E. Stevens, Alistair Ross, Walter Köckenberger, Ross James Macrae
Publikováno v:
Journal of Controlled Release. 92:341-347
Chronopharmaceutical capsules, ethylcellulose-coated to prevent water ingress, exhibited clearly different release characteristics when coated by organic or aqueous processes. Organic-coated capsules produced a delayed pulse release, whereas aqueous-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e78e9adbd074c1783efed6629a1aa6
https://doi.org/10.1016/s0168-3659(03)00341-9
https://doi.org/10.1016/s0168-3659(03)00341-9
Publikováno v:
Journal of Controlled Release. 89:457-471
THE OBJECTIVES OF THIS STUDY WERE: (i). to use blends of gastrointestinal tract (GIT)-insoluble and enteric polymers (ethyl cellulose and Eudragit L) as coating materials for multiparticulate controlled release dosage forms; (ii). to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e7cd9215b71acba88669d8881fe9c4
https://doi.org/10.1016/s0168-3659(03)00155-x
https://doi.org/10.1016/s0168-3659(03)00155-x
Publikováno v:
Journal of Pharmacy and Pharmacology. 52:903-909
We report the development of a chronopharmaceutical capsule drug delivery system capable of releasing drug after pre-determined time delays. The drug formulation is sealed inside the insoluble capsule body by an erodible tablet (ET). The release time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665c35dd4cf327d5b97b870ff41fd257
https://doi.org/10.1211/0022357001774787
https://doi.org/10.1211/0022357001774787
Publikováno v:
Drug development and industrial pharmacy. 36(2)
Purpose: Purpose of this study was to develop storage stable pellets coated with the aqueous ethylcellulose dispersion Aquacoat ECD. Methods: The influence of accelerated curing/storage conditions on the release behavior of Aquacoat/HPMC-coated drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228a0c401de2457e445e7b78a48e6e07
https://pubmed.ncbi.nlm.nih.gov/19555247
https://pubmed.ncbi.nlm.nih.gov/19555247
Publikováno v:
Pharmaceutical research. 22(7)
To elucidate the drug release mechanisms from pellets coated with pH-sensitive polymer blends. Verapamil hydrochloride-loaded beads were coated with various blends of a water-insoluble and an enteric polymer, ethylcellulose:Eudragit L and Eudragit NE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1222c8963ae278eb3a53d5ed9d0a87
https://pubmed.ncbi.nlm.nih.gov/16028014
https://pubmed.ncbi.nlm.nih.gov/16028014