Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ross J. Bland"'
Autor:
Heather V. Simpson, Peter H. Janssen, Ross J. Bland, Saleh Umair, Gemma Henderson, Gajenathirin Sinnathamby
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192164 (2018)
PLoS ONE, Vol 13, Iss 2, p e0192164 (2018)
Culture-independent methods were used to study the microbiota of adult worms, third-stage larvae and eggs, both in faeces and laid in vitro, of Haemonchus contortus, a nematode parasite of the abomasa of ruminants which is a major cause of production
Publikováno v:
Experimental Parasitology. 134:1-6
Sarcosine (N-methylglycine) is an intermediate in glycine degradation and can also be synthesised from glycine in mammals. Sarcosine metabolism in Haemonchus contortus and Teladorsagia circumcincta differed from that of mammals in that creatinase act
Publikováno v:
Experimental Parasitology. 129:115-119
A fully functional ornithine–glutamate–proline pathway was detected in L3 and adult Haemonchus contortus and Teladorsagia circumcincta, making the parasites capable of interconversion of these amino acids. Ornithine aminotransferase (OAT) (E.C. 2
Autor:
Helen L. Fitzsimons, Veronique Riban, Jennifer L. Wendelken, Ross J. Bland, Christine V. Sapan, Matthew J. During
Publikováno v:
The Journal of Gene Medicine. 12:385-398
Background The steps necessary to translate promising new biological therapies to the clinic are poorly documented. For gene therapy, there are unique aspects that need to be addressed in biodistribution studies. Notably, the spread of the vector bey
Autor:
Amy Baohan, Robert E. Burke, Ross J. Bland, Hsiao-Chun Cheng, Tatyana Kareva, Nikolai Kholodilov, Vincent Ries, Matthew J. During, Tinmarla F. Oo, Margarita Rzhetskaya
Publikováno v:
Journal of Neurochemistry. 110:23-33
Following mitosis, specification and migration during embryogenesis, dopamine neurons of the mesencephalon undergo a postnatal naturally occurring cell death event that determines their final adult number, and a period of axonal growth that determine
Autor:
Asla Pitkänen, Ross J. Bland, Matthew J. During, Helen L. Fitzsimons, Francesco Ferraguti, Annamaria Vezzani, Francesco Noé, Mirjana Carli, Günther Sperk, Claudia Balducci, Angelisa Frasca
Publikováno v:
Neurotherapeutics. 6:300-306
Gene therapy may represent a promising alternative treatment of epileptic patients who are resistant to conventional anti-epileptic drugs. Among the various approaches for the application of gene therapy in the treatment of CNS disorders, recombinant
Publikováno v:
Molecular Therapy. 16:1048-1055
Defects in cellular quality control mechanisms are thought to contribute to the neuropathology of Parkinson's disease (PD). Overexpressing heat shock proteins (HSPs) may constitute a powerful therapeutic strategy for PD, because they boost the abilit
Autor:
Francesco Ferraguti, Ross J. Bland, Francesco Noé, Claudia Balducci, Asla Pitkänen, Annamaria Vezzani, Allan-Hermann Pool, Matthew J. During, Marco Gobbi, Gunther Sperk, Massimo Rizzi, Jari Nissinen
Publikováno v:
Brain. 131:1506-1515
Temporal lobe epilepsy remains amongst the most common and drug refractory of neurological disorders. Gene therapy may provide a realistic therapeutic approach alternative to surgery for intractable focal epilepsies. To test this hypothesis, we appli
Autor:
Ross J. Bland, Margarita Rzhetskaya, A. William Tank, Nikolai Kholodilov, Xiqun Chen, Robert E. Burke, Matthew J. During, Tatyana Kareva
Publikováno v:
The Journal of Neuroscience. 28:672-680
There is extensive evidence that the mitogen-activated protein kinase (MAPK) signaling cascade mediates programmed cell death in neurons. However, current evidence that the mixed linage kinases (MLKs), upstream in this cascade, mediate cell death is
Autor:
Chengke Tang, Deborah Young, Paul J. Mattis, P. Lawlor, Helen L. Fitzsimons, David Eidelberg, Ross J. Bland, Michael G. Kaplitt, Matthew J. During, Andrew Feigin, Kristin Strybing
Publikováno v:
The Lancet. 369:2097-2105
Summary Background Dopaminergic neuronal loss in Parkinson's disease leads to changes in the circuitry of the basal ganglia, such as decreased inhibitory GABAergic input to the subthalamic nucleus. We aimed to measure the safety, tolerability, and po