Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Ross J, Porter"'
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Akademický článek
Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate
Autor: Ross J Porter, Graeme I Murray, Abdo Alnabulsi, Matthew P Humphries, Jacqueline A James, Manuel Salto‐Tellez, Stephanie G Craig, Ji M Wang, Teizo Yoshimura, Mairi H McLean
Publikováno v: The Journal of Pathology: Clinical Research, Vol 7, Iss 5, Pp 495-506 (2021)
Abstract Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the colonic epithelial expression of cathelicidin (LL‐37) in CRC. Cathelicidin exerts pleotropic effects including anti‐microbial and immunoregulatory f
Externí odkaz: https://doaj.org/article/ba815979fd8d47278716bcad2a4d676c
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2
Akademický článek
QuPath Algorithm Accurately Identifies MLH1-Deficient Inflammatory Bowel Disease-Associated Colorectal Cancers in a Tissue Microarray
Autor: Ross J. Porter, Shahida Din, Peter Bankhead, Anca Oniscu, Mark J. Arends
Publikováno v: Diagnostics, Vol 13, Iss 11, p 1890 (2023)
Current methods for analysing immunohistochemistry are labour-intensive and often confounded by inter-observer variability. Analysis is time consuming when identifying small clinically important cohorts within larger samples. This study trained QuPat
Externí odkaz: https://doaj.org/article/862b35c3db57464a85fbcd3ecee2edc7
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3
Akademický článek
Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model
Autor: Daniel P. Brice, Graeme I. Murray, Heather M. Wilson, Ross J. Porter, Susan Berry, Scott K. Durum, Mairi H. McLean
Publikováno v: Biology, Vol 11, Iss 3, p 427 (2022)
A treatment with direct healing effects on the gastrointestinal epithelial barrier is desirable for inflammatory bowel disease (IBD). Interleukin-27 (IL-27) is an immunoregulatory cytokine, and oral delivery is an effective treatment in murine models
Externí odkaz: https://doaj.org/article/bfd3bdd5fc0849e49ba926846b57a200
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4
c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions
Autor: Grant, Halliday, Ross J, Porter, Catherine J, Black, Mark J, Arends, Shahida, Din
Publikováno v: Halliday, G, Porter, R J, Black, C J, Arends, M J & Din, S 2022, ' c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions ', World Journal of Gastroenterology . https://doi.org/10.3748/wjg.v28.i13.1338
BACKGROUNDPost-colonoscopy colorectal cancer (CRC) rates for patients with inflammatory bowel disease (IBD) are unacceptably high. During colonoscopy, an intravenous fluorescent anti-c-MET probe may improve endoscopic detection of lesions. However, c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fd185fa1ff628a8d5f3c427ad98e16
https://doi.org/10.3748/wjg.v28.i13.1338
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5
Subcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an ‘Immune Cold’ Phenotype Associated with Poor Survival
Autor: Ross J. Porter, Graeme I. Murray, Sandra Hapca, Andrew Hay, Stephanie G. Craig, Matthew P. Humphries, Jacqueline A. James, Manuel Salto-Tellez, Daniel P. Brice, Susan H. Berry, Mairi H. McLean
Publikováno v: Cancers; Volume 15; Issue 6; Pages: 1865
Porter, R J, Murray, G I, Hapca, S, Hay, A, Craig, S G, Humphries, M P, James, J A, Salto-Tellez, M, Brice, D P, Berry, S H & McLean, M H 2023, ' Subcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an ‘Immune Cold’ Phenotype Associated with Poor Survival ', Cancers, vol. 15, no. 6, 1865 . https://doi.org/10.3390/cancers15061865
Porter, R J, Murray, G I, Hapca, S, Hay, A, Craig, S G, Humphries, M P, James, J A, Salto-Tellez, M, Brice, D P, Berry, S H & McLean, M H 2023, ' Subcellular epithelial HMGB1 expression is associated with colorectal neoplastic progression, male sex, mismatch repair protein expression, lymph node positivity, and an 'immune cold' phenotype associated with poor survival ', Cancers, vol. 15, no. 6, 1865, pp. 1865 . https://doi.org/10.3390/cancers15061865
New treatment targets are needed for colorectal cancer (CRC). We define expression of High Mobility Group Box 1 (HMGB1) protein throughout colorectal neoplastic progression and examine the biological consequences of aberrant expression. HMGB1 is a ub
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26eef120374bc4eb411d6c937144162c
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6
Endoscopically placed venting gastrostomy can be a safe and effective palliative intervention in benign and malignant gastrointestinal obstruction
Autor: Emma L Metcalfe, Alastair W. McKinlay, Ross J Porter
Publikováno v: Frontline Gastroenterol
IntroductionChronic gastrointestinal obstruction can precipitate a constellation of symptoms including nausea, vomiting, abdominal distension and pain that negatively impact on health-related quality of life. Decompression via venting gastrostomy can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2bd744fb2d253698e2e3a748b2cc5a
https://doi.org/10.1136/flgastro-2021-101930
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7
Colonic epithelial cathelicidin ( LL ‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8 + T cell infiltrate
Autor: Manuel Salto-Tellez, Stephanie G Craig, Graeme I. Murray, Abdo Alnabulsi, Mairi H. McLean, Ross J Porter, Ji Ming Wang, Matthew P. Humphries, Teizo Yoshimura, Jacqueline James
Publikováno v: The Journal of Pathology: Clinical Research, Vol 7, Iss 5, Pp 495-506 (2021)
Porter, R J, Murray, G I, Alnabulsi, A, Humphries, M P, James, J A, Salto-Tellez, M, Craig, S G, Wang, J M, Yoshimura, T & McLean, M H 2021, ' Colonic epithelial cathelicidin (LL-37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate ', Journal of Pathology: Clinical Research . https://doi.org/10.1002/cjp2.222
Porter, R J, Murray, G I, Alnabulsi, A, Humphries, M P, James, J A, Salto-Tellez, M, Craig, S G, Wang, J M, Yoshimura, T & McLean, M H 2021, ' Colonic epithelial cathelicidin ( LL -37) expression intensity is associated with progression of colorectal cancer and presence of CD8 + T cell infiltrate ', The Journal of Pathology: Clinical Research, vol. 7, no. 5, pp. 495-506 . https://doi.org/10.1002/cjp2.222, https://doi.org/10.1002/cjp2.222
Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the colonic epithelial expression of cathelicidin (LL‐37) in CRC. Cathelicidin exerts pleotropic effects including anti‐microbial and immunoregulatory functions.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b572f51a0443baf98adf098ef052db5e
https://doi.org/10.1002/cjp2.222
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8
Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus
Autor: James A. Evans, Emanuela Carlotti, Meng-Lay Lin, Richard J. Hackett, Magnus J. Haughey, Adam M. Passman, Lorna Dunn, George Elia, Ross J. Porter, Mairi H. McLean, Frances Hughes, Joanne ChinAleong, Philip Woodland, Sean L. Preston, S. Michael Griffin, Laurence Lovat, Manuel Rodriguez-Justo, Weini Huang, Nicholas A. Wright, Marnix Jansen, Stuart A.C. McDonald
Publikováno v: Evans, J A, Carlotti, E, Lin, M-L, Hackett, R J, Haughey, M J, Passman, A M, Dunn, L, Elia, G, Porter, R J, McLean, M H, Hughes, F, ChinAleong, J, Woodland, P, Preston, S L, Griffin, S M, Lovat, L, Rodriguez-Justo, M, Huang, W, Wright, N A, Jansen, M & McDonald, S A C 2021, ' Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus ', Gastroenterology . https://doi.org/10.1053/j.gastro.2021.12.271
BACKGROUND & AIMS: Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma but our understanding of how it evolves is poorly understood. We investigated BE gland phenotype distribution, the clonal nature of phenotypic change, and how
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ce501697431493a43d2e17fdea462c
https://hdl.handle.net/20.500.11820/86dd8044-f515-481a-8ca6-c44362bdc748
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