Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ross H. Durland"'
Autor:
Ross H. Durland, David G. Gorenstein, David E. Volk, Weiguo He, Xin Li, Ganesh L.R. Lokesh, Claudio N. Cavasotto, Johnnie Englehardt, Miguel Angel Elizondo-Riojas, Varatharasa Thiviyanathan, Anoma Somasunderam
Publikováno v:
Biochemistry. 51:8321-8323
By combining pseudorandom bead-based aptamer libraries with conjugation chemistry, we have created next-generation aptamers, X-aptamers (XAs). Several X-ligands can be added in a directed or random fashion to the aptamers to further enhance their bin
Autor:
Nilabh Chaudhary, Ganapathi R. Revankar, V. Bodepudi, T. S. Rao, J. Guy-Caffey, Krishna Jayaraman, Ross H. Durland
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:951-955
The ability of simple azole nucleosides to promote antiparallel triplex formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhancing cellular uptake and stability of olig
Publikováno v:
Nucleosides and Nucleotides. 14:45-63
A convenient synthesis of 1-(2-deoxy-β-D-erythro-pentofuranosyl)quinazoline-2,4(3H)-dione ( 6 ) has been accomplished. The structural conformation of ( 6 ) was derived by 2D NMR, COSY and NOESY experiments. Nucleoside ( 6 ) was incorporated into G-r
Autor:
Ganapathi R. Revankar, Ross H. Durland, Veeraiah Bodepudi, Melissa A. Myrick, Dale M. Seth, T. Sudhakar Rao
Publikováno v:
Biochemistry. 34:765-772
An efficient and expeditious method for the synthesis of S6-(cyanoethyl)-N2-isobutyryl (or trifluoroacetyl)-2'-deoxy-6-thioguanosine (7 and 2) from 2'-deoxyguanosine (G) has been developed. Compound 7 has been incorporated into several G-rich triple-
Autor:
Ross H. Durland, Dale M. Seth, Veeraiah Bodepudi, Krishna Jayaraman, Ganapathi R. Revankar, T. Sudhakar Rao
Publikováno v:
Nucleic Acids Research. 23:647-653
The ability of certain azole substituted oligodeoxy-ribonucleotides to promote antiparallel triple helix formation with duplex targets having CG or TA interruptions in the otherwise homopurine sequence was examined. 2'-Deoxyribonucleosides of the azo
Publikováno v:
Journal of Heterocyclic Chemistry. 31:935-940
The synthesis of oligonucleotides containing 7-(2-deoxy-β-D-erythro-pentofuranosyl)guanine and 8-amino-2′-deoxyguanosine was accomplished. The viable intermediate N2-isobutyryl-7-(2-deoxy-β-D-erythro-pentofuranosyl)guanine (6) was prepared via a
Publikováno v:
Nucleosides and Nucleotides. 13:255-273
Total synthesis of novel DMT-phosphoramidites of thymidine (11 and 15) and 2′-deoxyguanosine (8 and 20) have been accomplished. The utility of these modified building blocks in the preparation of triple helix forming oligodeoxyribonucleotides with
Autor:
Pradeep Singh, John H. Tinsley, Ross H. Durland, Ganapathi R. Revankar, Krishna Jayaraman, Jamie Rayford, Melissa A. Myrick, Dale M. Seth, T. Sudhakar Rao
Publikováno v:
Nucleic Acids Research. 22:3233-3240
The goal of this study was to address antiparallel triplex formation at duplex targets that do not conform to a strict oligopurine.oligopyrimidine motif. We focused on the ability of natural bases and base analogs incorporated into oligonucleotide th
Publikováno v:
Gene. 133:1-8
Mini-replicons of the broad-host-range plasmid RK2 with increased copy number (cn) due to mutations in the gene encoding the essential replication initiation protein TrfA are described. The cn of these derivatives have been determined in Escherichia
Publikováno v:
Tetrahedron Letters. 33:7651-7654
A simple and expeditious synthesis of S 6 -cyanoethyl-2′-deoxy-6-thioguanosine from 2′-deoxyguanosine has been accomplished in good yield and incorporated into several triple helix forming oligonucleotides using the solid-phase phosphoramidite ch