Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ross G, Cameron"'
Publikováno v:
Liver. 22:235-244
Background/aims: Primary biliary cirrhosis (PBC) is a chronic liver disease that results in cholestasis and bile duct loss. Ursodeoxycholic acid (UDCA) has been shown to reduce hepatocellular damage in PBC. The study attempted to quantify perisinusoi
Autor:
Manuela G Neuman, Gady G Katz, Pearl Jacobson-Brown, Izabella M. Malkiewicz, Heather K Neilson, Neil H. Shear, Ross G. Cameron, Frank S. Abbott
Publikováno v:
Clinical Biochemistry. 34:211-218
Objectives: To determine the cytotoxicity of valproic acid (VPA) and its metabolite, 4-ene-valproic acid (4-ene-VPA) in human hepatoblastoma cells (Hep G2), and to study the modulatory effect of cytochrome P450 2E1 induction in this model. Methods: C
Publikováno v:
Clinical Biochemistry. 34:195-201
Objectives: To determine what changes are occurring in patients with primary sclerosing cholangitis (PSC) by examining perisinusoidal macrophages (Kupffer cells) in liver biopsies; 2-to measure transforming growth factor beta (TGFβ) as a marker of f
Autor:
Neil H Shear, Gady G. Katz, Ross G. Cameron, Izabella M. Malkiewicz, Manuela G Neuman, Julia A Haber
Publikováno v:
Clinical Biochemistry. 32:519-536
To study the effect of cytochrome P450 2E1-inducers on methotrexate (MTX)-induced cytotoxicity in human hepatocytes, and investigate the role of silymarin in preventing this toxicity.Cells were exposed to MTX in the presence of either ethanol (EtOH)
Autor:
Ross G. Cameron, Manuela G. Neuman
Publikováno v:
Clinical Biochemistry. 32:579-584
To study light and electron microscopic changes in alcohol-liver disease (ALD) patients, and characterize the expression pattern of Kupffer and stellate cells, correlating changes with serum cytokine levels.Liver biopsies studied in 35 ALD patients w
Autor:
Ross G. Cameron, George Feuer
Apoptosis is a fascinating concept for the basic scientist. This is not only because of the multifaceted variety of proposed and discovered mechanisms, but because apoptosis represents a fundamental pathway for cell renewal. The study of apoptosis ha
Autor:
Kenneth A. Fleming, Douglas M. Templeton, Robert A. McClelland, Nancy F. Olivieri, Gary M. Brittenham, Ross G. Cameron, Alastair D. Burt, Christine E. McLaren
Publikováno v:
New England Journal of Medicine. 339:417-423
Deferiprone is an orally active iron-chelating agent that is being evaluated as a treatment for iron overload in thalassemia major. Studies in an animal model showed that prolonged treatment is associated with a decline in the effectiveness of deferi
Publikováno v:
Journal of Parenteral and Enteral Nutrition. 21:7-13
Background: We previously showed that continuous infusion of tumor necrosis factor-α (TNF-α) in orally fed rats caused weight and muscle wasting mainly because of anorexia. However, when we tried to prevent weight loss by giving total parenteral nu
Autor:
Hiroshi Yamasaki, Gerald Batist, Hisayoshi Nakazawa, Nasser Fotouhi-Ardakani, Moulay A. Alaoui-Jamali, Michael C. Kew, Gordon M. Kirby, Ross G. Cameron
Publikováno v:
International Journal of Cancer. 68:21-25
AGG to AGT mutations in codon 249 of the p53 tumor-suppressor gene are frequently observed in hepatocellular carcinomas (HCC) from areas where exposure to aflatoxin B1 (AFB) occurs. We developed a sensitive allele-specific polymerase chain reaction (
Autor:
Ross G. Cameron, Gideon Koren, Robert A. McClelland, Nancy F. Olivieri, Douglas M. Templeton, Gary M. Brittenham, Peter P. Liu, Doreen Matsui, Matitiahu Berkovitch, Laurence M. Blendis
Publikováno v:
New England Journal of Medicine. 332:918-922
Background To determine whether the orally active iron chelator deferiprone (1,2-dimethyl-3-hydroxypyridin-4-one) is efficacious in the treatment of iron overload in patients with thalassemia major, we conducted a prospective trial of deferiprone in