Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ross E. Granrath"'
Autor:
Micah G. Donovan, Neetha P. Eduthan, Keith P. Smith, Eleanor C. Britton, Hannah R. Lyford, Paula Araya, Ross E. Granrath, Katherine A. Waugh, Belinda Enriquez Estrada, Angela L. Rachubinski, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong inter-individual variability in terms of developmental phenotypes and diagnosis of co-occurring conditions. The mechanisms underlying this variable de
Externí odkaz:
https://doaj.org/article/9c8d84e2b387481eb0fa610529c4f865
Autor:
Micah G. Donovan, Angela L. Rachubinski, Keith P. Smith, Paula Araya, Katherine A. Waugh, Belinda Enriquez-Estrada, Eleanor C. Britton, Hannah R. Lyford, Ross E. Granrath, Kyndal A. Schade, Kohl T. Kinning, Neetha Paul Eduthan, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114599- (2024)
Summary: Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions. Hypoxemia and dysregulated hematopoiesis have been doc
Externí odkaz:
https://doaj.org/article/899484d6d7604ee5ad8c1bd6d67a98fd
Autor:
Rani K. Powers, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona-Iragui, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy numbe
Externí odkaz:
https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d85
Autor:
Katherine A. Waugh, Paula Araya, Ahwan Pandey, Kimberly R. Jordan, Keith P. Smith, Ross E. Granrath, Santosh Khanal, Eric T. Butcher, Belinda Enriquez Estrada, Angela L. Rachubinski, Jennifer A. McWilliams, Ross Minter, Tiana Dimasi, Kelley L. Colvin, Dmitry Baturin, Andrew T. Pham, Matthew D. Galbraith, Kyle W. Bartsch, Michael E. Yeager, Christopher C. Porter, Kelly D. Sullivan, Elena W. Hsieh, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1893-1908.e4 (2019)
Summary: People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence of neurological and autoimmune conditions. However, the mech
Externí odkaz:
https://doaj.org/article/5e8ba4aab3a0402a9359cd3e3d5c2332
Autor:
Matthew D Galbraith, Kohl T Kinning, Kelly D Sullivan, Ryan Baxter, Paula Araya, Kimberly R Jordan, Seth Russell, Keith P Smith, Ross E Granrath, Jessica R Shaw, Monika Dzieciatkowska, Tusharkanti Ghosh, Andrew A Monte, Angelo D'Alessandro, Kirk C Hansen, Tellen D Benett, Elena WY Hsieh, Joaquín M Espinosa
Publikováno v:
eLife, Vol 10 (2021)
COVID19 is a heterogeneous medical condition involving diverse underlying pathophysiological processes including hyperinflammation, endothelial damage, thrombotic microangiopathy, and end-organ damage. Limited knowledge about the molecular mechanisms
Externí odkaz:
https://doaj.org/article/c5f457f7384b4b44a7d4aef02aa82ab3
Autor:
Belinda Enriquez-Estrada, Jessica R Shaw, Ross E Granrath, Angela L. Rachubinski, Joaquín M. Espinosa, Kohl T Kinning, L. Alexander Liggett, James DeGregori, Matthew D. Galbraith, Kelly D. Sullivan, Keith P Smith
Publikováno v:
Blood Adv
Key Points Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disru
Autor:
Matthew D. Galbraith, Kohl T. Kinning, Kelly D. Sullivan, Paula Araya, Keith P. Smith, Ross E. Granrath, Jessica R. Shaw, Ryan Baxter, Kimberly R. Jordan, Seth Russell, Monika Dzieciatkowska, Julie A. Reisz, Fabia Gamboni, Francesca Cendali, Tusharkanti Ghosh, Kejun Guo, Cara C. Wilson, Mario L. Santiago, Andrew A. Monte, Tellen D. Bennett, Kirk C. Hansen, Elena W. Y. Hsieh, Angelo D’Alessandro, Joaquin M. Espinosa
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both protective and harmful effects being documented. We report here a multiomics investigation of systemic IFN signaling in hospitalized COVID-19 patients, defining t
Autor:
Katherine A. Waugh, Ross Minter, Jessica Baxter, Congwu Chi, Kathryn D. Tuttle, Neetha P. Eduthan, Matthew D. Galbraith, Kohl T. Kinning, Zdenek Andrysik, Paula Araya, Hannah Dougherty, Lauren N. Dunn, Michael Ludwig, Kyndal A. Schade, Dayna Tracy, Keith P. Smith, Ross E. Granrath, Nicolas Busquet, Santosh Khanal, Ryan D. Anderson, Liza L. Cox, Belinda Enriquez Estrada, Angela L. Rachubinski, Hannah R. Lyford, Eleanor C. Britton, David J. Orlicky, Jennifer L. Matsuda, Kunhua Song, Timothy C. Cox, Kelly D. Sullivan, Joaquin M. Espinosa
Trisomy 21 causes Down syndrome, a condition characterized by cognitive impairments, immune dysregulation, and atypical morphogenesis. Using whole blood transcriptome analysis, we demonstrate that specific overexpression of four interferon receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0537897f7410b5176b3650f94e662bc
https://doi.org/10.1101/2022.02.03.478982
https://doi.org/10.1101/2022.02.03.478982
Autor:
Kelley L. Colvin, Kyle Bartsch, Ross Minter, Belinda Enriquez Estrada, Katherine A. Waugh, Tiana Dimasi, Angela L. Rachubinski, Ross E Granrath, Michael E. Yeager, Keith P Smith, Kelly D. Sullivan, Paula Araya, Jennifer A. McWilliams, Dmitry Baturin, Joaquín M. Espinosa, Matthew D. Galbraith, Kimberly R. Jordan, Santosh Khanal, Andrew T. Pham, Christopher C. Porter, Eric T. Butcher, Elena W Y Hsieh, Ahwan Pandey
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1893-1908.e4 (2019)
Summary: People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence of neurological and autoimmune conditions. However, the mech
Autor:
Paula Araya, Kohl T. Kinning, Christina Coughlan, Keith P. Smith, Ross E. Granrath, Belinda A. Enriquez-Estrada, Kayleigh Worek, Kelly D. Sullivan, Angela L. Rachubinski, Kristine Wolter-Warmerdam, Francis Hickey, Matthew D. Galbraith, Huntington Potter, Joaquin M. Espinosa
Publikováno v:
Cell Reports. 41:111883
Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by stunted growth, cognitive impairment, and increased risk of diverse neurological conditions. Although signs of lifelong neurodegeneration are well documented in