Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Ross Dobie"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a992117824d74b4e8e82eb45561f81f7
Autor:
Rose Ruiz Daniels, Richard S Taylor, Ross Dobie, Sarah Salisbury, James J Furniss, Emily Clark, Daniel J Macqueen, Diego Robledo
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0285020 (2023)
The use of single cell sequencing technologies has exploded over recent years, and is now commonly used in many non-model species. Sequencing nuclei instead of whole cells has become increasingly popular, as it does not require the processing of samp
Externí odkaz:
https://doaj.org/article/ab19d3068c284b06a2fe44636f13ed42
Autor:
Phoebe M Kirkwood, Douglas A Gibson, Isaac Shaw, Ross Dobie, Olympia Kelepouri, Neil C Henderson, Philippa TK Saunders
Publikováno v:
eLife, Vol 11 (2022)
The human endometrium experiences repetitive cycles of tissue wounding characterised by piecemeal shedding of the surface epithelium and rapid restoration of tissue homeostasis. In this study, we used a mouse model of endometrial repair and three tra
Externí odkaz:
https://doaj.org/article/7eaf0612c02f426aa9291a9e9c6f5a01
Autor:
Martine Manuel, Kai Boon Tan, Zrinko Kozic, Michael Molinek, Tiago Sena Marcos, Maizatul Fazilah Abd Razak, Dániel Dobolyi, Ross Dobie, Beth E P Henderson, Neil C Henderson, Wai Kit Chan, Michael I Daw, John O Mason, David J Price
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001563 (2022)
The development of stable specialized cell types in multicellular organisms relies on mechanisms controlling inductive intercellular signals and the competence of cells to respond to such signals. In developing cerebral cortex, progenitors generate o
Externí odkaz:
https://doaj.org/article/e095303f3e8640019b40c0c448f676c2
Autor:
Richard S. Taylor, Rose Ruiz Daniels, Ross Dobie, Shahmir Naseer, Thomas C. Clark, Neil C. Henderson, Pierre Boudinot, Samuel A.M. Martin, Daniel J. Macqueen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The liver is a multitasking organ with essential functions for vertebrate health spanning metabolism and immunity. In contrast to mammals, our understanding of liver cellular heterogeneity and its role in regulating immunological status remains poorl
Externí odkaz:
https://doaj.org/article/acce3d03cf184fd0a9a9c084590d564f
Autor:
Duncan C. Humphries, Ross Mills, Ross Dobie, Neil C. Henderson, Tariq Sethi, Alison C. Mackinnon
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Rationale: Galectin-3 (Gal-3) is an immune regulator and an important driver of fibrosis in chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Previous work has shown that global deletion of galectin-3 reduces collagen
Externí odkaz:
https://doaj.org/article/514aa246c23f4d81a2d479d419fca3f5
Autor:
Ross Dobie, John R. Wilson-Kanamori, Beth E.P. Henderson, James R. Smith, Kylie P. Matchett, Jordan R. Portman, Karolina Wallenborg, Simone Picelli, Anna Zagorska, Swetha V. Pendem, Thomas E. Hudson, Minnie M. Wu, Grant R. Budas, David G. Breckenridge, Ewen M. Harrison, Damian J. Mole, Stephen J. Wigmore, Prakash Ramachandran, Chris P. Ponting, Sarah A. Teichmann, John C. Marioni, Neil C. Henderson
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1832-1847.e8 (2019)
Summary: Iterative liver injury results in progressive fibrosis disrupting hepatic architecture, regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of pathological matrix during fibrosis and are thought to be
Externí odkaz:
https://doaj.org/article/3e037994cd354294a9745ce74fc85275
Autor:
Katherine Martin, James Pritchett, Jessica Llewellyn, Aoibheann F. Mullan, Varinder S. Athwal, Ross Dobie, Emma Harvey, Leo Zeef, Stuart Farrow, Charles Streuli, Neil C. Henderson, Scott L. Friedman, Neil A. Hanley, Karen Piper Hanley
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Antifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibr
Externí odkaz:
https://doaj.org/article/f88a909827dd4238bbf8364f30631af2
Autor:
Ross Dobie, Vicky E. MacRae, Chloe Pass, Elspeth M. Milne, S. Faisal Ahmed, Colin Farquharson
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
Individuals with inflammatory bowel disease (IBD) often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multif
Externí odkaz:
https://doaj.org/article/1fc18fddd0d3483e9b46d23e4866c5f0
Autor:
Ross Dobie, Neil C. Henderson
Publikováno v:
F1000Research, Vol 5 (2016)
Despite the high prevalence of liver disease globally, there are currently no approved anti-fibrotic therapies to treat patients with liver fibrosis. A major goal in anti-fibrotic therapy is the development of drug delivery systems that allow direct
Externí odkaz:
https://doaj.org/article/83f0089a32924d4b919f48992fe5768c