Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ross D Jones"'
Autor:
Laura Prochazka, Yale S Michaels, Charles Lau, Ross D Jones, Mona Siu, Ting Yin, Diana Wu, Esther Jang, Mercedes Vázquez‐Cantú, Penney M Gilbert, Himanshu Kaul, Yaakov Benenson, Peter W Zandstra
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 11, Pp 1-22 (2022)
Abstract During development, cell state transitions are coordinated through changes in the identity of molecular regulators in a cell type‐ and dose‐specific manner. The ability to rationally engineer such transitions in human pluripotent stem ce
Externí odkaz:
https://doaj.org/article/e2b62297353c4d7b84600c9edd7e25df
Autor:
Ross D. Jones, Yili Qian, Katherine Ilia, Benjamin Wang, Michael T. Laub, Domitilla Del Vecchio, Ron Weiss
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Engineered signaling networks can impart cells with new functionalities useful for directing differentiation and actuating cellular therapies. For such applications, the engineered networks must be tunable, precisely regulate target gene exp
Externí odkaz:
https://doaj.org/article/07b7c8171973444cb2597e662547c991
Autor:
Ross D. Jones, Yili Qian, Velia Siciliano, Breanna DiAndreth, Jin Huh, Ron Weiss, Domitilla Del Vecchio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Accurately predicting the behaviour of a genetic circuit remains difficult due to the lack of modularity. Here the authors quantify the effects of resource loading in mammalian systems and develop an endoribonuclease-based feedfoward controller to ad
Externí odkaz:
https://doaj.org/article/41ee51a0778e4e32aca6ad6f2f5dcaae
Autor:
Laura N Stankiewicz, Kevin Salim, Emily A Flaschner, Yu Xin Wang, John M Edgar, Bruce ZB Lin, Grace C Bingham, Matthew C Major, Ross D Jones, Helen M Blau, Elizabeth J Rideout, Megan K Levings, Peter W Zandstra, Fabio MV Rossi
Publikováno v:
bioRxiv
SummaryWithin the thymus, regulation of the cellular cross-talk directing T cell development is dependent on spatial interactions within specialized niches. To create a holistic, spatially defined map of tissue niches guiding postnatal T cell develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7bca0c46114847f2a5ad4602946ecd
https://doi.org/10.1101/2023.04.13.536804
https://doi.org/10.1101/2023.04.13.536804
Autor:
Katherine Ilia, Nika Shakiba, Trevor Bingham, Ross D. Jones, Michael M. Kaminski, Eliezer Aravera, Simone Bruno, Sebastian Palacios, Ron Weiss, James J. Collins, Domitilla Del Vecchio, Thorsten M. Schlaeger
Publikováno v:
bioRxiv
Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless, the impact of TF dynamics on reprogramming efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de8cfc6528e5f4ee2f132f694f1c2f3
https://europepmc.org/articles/PMC9900859/
https://europepmc.org/articles/PMC9900859/
Publikováno v:
Cell Syst
The rise of systems biology has ushered a new paradigm: the view of the cell as a system that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides a complementary approach, allowing us to program cell behavior throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022960c03c7409696a496510e19585d3
https://doi.org/10.1016/j.cels.2021.05.011
https://doi.org/10.1016/j.cels.2021.05.011
Autor:
Himanshu Kaul, Nicolas Werschler, Ross D. Jones, M. Mona Siu, Mukul Tewary, Andrew Hagner, Joel Ostblom, Daniel Aguilar-Hidalgo, Peter W. Zandstra
Publikováno v:
Stem cell reports.
The mechanism by which morphogenetic signals engage the regulatory networks responsible for early embryonic tissue patterning is incompletely understood. Here, we developed a minimal gene regulatory network (GRN) model of human pluripotent stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68201ec864ba33f30f319658e642a228
https://pubmed.ncbi.nlm.nih.gov/36332630
https://pubmed.ncbi.nlm.nih.gov/36332630
Autor:
Ilia K, Domitilla Del Vecchio, Yili Qian, Ron Weiss, Michael T. Laub, Ross D. Jones, Benjamin X. Wang
Publikováno v:
Nature Communications. 13
Rewired and synthetic signaling networks can impart cells with new functionalities and enable efforts in engineering cell therapies and directing cell development. However, there is a need for tools to build synthetic signaling networks that are tuna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260943b066080fc2e59a198c7d4b05ba
https://doi.org/10.1038/s41467-022-29338-w
https://doi.org/10.1038/s41467-022-29338-w
Autor:
Himanshu Kaul, M. Siu, Peter W. Zandstra, D. Wu, Yaakov Benenson, Ting Yin, M. Vazquez-Cantu, Ross D. Jones, L. Prochazka, E. Jang, C. Lau, Penney M. Gilbert, Y. S. Michaels
During development, state transitions are coordinated through changes in the identity of molecular regulators in a cell state- and dose specific manner. The ability to rationally engineer such functions in human pluripotent stem cells (hPSC) will ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69ab9ef5124fb128b772ba9565d74c8d
https://doi.org/10.1101/2021.11.05.467377
https://doi.org/10.1101/2021.11.05.467377
Autor:
Domitilla Del Vecchio, Ron Weiss, Velia Siciliano, Breanna DiAndreth, Yili Qian, Jin Huh, Ross D. Jones
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Synthetic biology has the potential to bring forth advanced genetic devices for applications in healthcare and biotechnology. However, accurately predicting the behavior of engineered genetic devices remains difficult due to lack of modularity, where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068b5e192c1eb14db618e02343897ead
https://doi.org/10.1101/867028
https://doi.org/10.1101/867028