Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Ross D Hannan"'
Autor:
Chue Vin Chin, Jisha Antony, Sarada Ketharnathan, Anastasia Labudina, Gregory Gimenez, Kate M Parsons, Jinshu He, Amee J George, Maria Michela Pallotta, Antonio Musio, Antony Braithwaite, Parry Guilford, Ross D Hannan, Julia A Horsfield
Publikováno v:
eLife, Vol 9 (2020)
Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21,
Externí odkaz:
https://doaj.org/article/468478a941f34ce89b0313a4e6cc727f
Autor:
Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga, Katherine M Hannan, Ross D Hannan, Gloria Rudenko
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005432 (2017)
Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other eukaryotes e
Externí odkaz:
https://doaj.org/article/4a35b7495b2f4c1d877fe6f8ca6eb7b2
Autor:
Jeannine Diesch, Elaine Sanij, Omer Gilan, Christopher Love, Hoanh Tran, Nicholas I Fleming, Jason Ellul, Marcia Amalia, Izhak Haviv, Richard B Pearson, Eugene Tulchinsky, John M Mariadason, Oliver M Sieber, Ross D Hannan, Amardeep S Dhillon
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e88950 (2014)
Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown to drive overexpression of the AP
Externí odkaz:
https://doaj.org/article/d7fe9ee98a4f408bb231db36ea198d14
Autor:
Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, Graham J Lieschke, Didier Y R Stainier, Joan K Heath
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003279 (2013)
Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel
Externí odkaz:
https://doaj.org/article/f2b587b2488b4beba385b93b524c7da4
Autor:
Simon R Foster, Enzo R Porrello, Brooke Purdue, Hsiu-Wen Chan, Anja Voigt, Sabine Frenzel, Ross D Hannan, Karen M Moritz, David G Simmons, Peter Molenaar, Eugeni Roura, Ulrich Boehm, Wolfgang Meyerhof, Walter G Thomas
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64579 (2013)
G protein-coupled receptors (GPCRs) are critical for cardiovascular physiology. Cardiac cells express >100 nonchemosensory GPCRs, indicating that important physiological and potential therapeutic targets remain to be discovered. Moreover, there is a
Externí odkaz:
https://doaj.org/article/7c2bf768ea8240dfabe8a4383dab9b91
Autor:
Jane I Lin, Naomi C Mitchell, Marina Kalcina, Elly Tchoubrieva, Mary J Stewart, Steven J Marygold, Cherryl D Walker, George Thomas, Sally J Leevers, Richard B Pearson, Leonie M Quinn, Ross D Hannan
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002408 (2011)
The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as tumour suppressors in Drosophila and vertebrates. To examine how reductions in Rps could lead
Externí odkaz:
https://doaj.org/article/fca2638bcbb24c7889f06530e5409653
Autor:
Chang-Won Kang, Anneke C. Blackburn, Amos Hong Pheng Loh, Kuick Chick Hong, Jian Yuan Goh, Nadine Hein, Denis Drygin, Chris R. Parish, Ross D. Hannan, Katherine M. Hannan, Lucy A. Coupland
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1133 (2023)
The survival rate of patients with osteosarcoma (OS) has not improved over the last 30 years. Mutations in the genes TP53, RB1 and c-Myc frequently occur in OS and enhance RNA Polymerase I (Pol I) activity, thus supporting uncontrolled cancer cell pr
Externí odkaz:
https://doaj.org/article/828e24308c6e4101a33cd536ee4eaae4
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
All Supplementary Methods and associated references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019c8dd00fb9804dbcab5c9c85324ed7
https://doi.org/10.1158/2159-8290.22537003
https://doi.org/10.1158/2159-8290.22537003
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and its dysregulation is a common feature in cancer. We evaluated CX-5461, the first-in-class selective rDNA transcription inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918b37c279b207d3fe24ae1fef2b4322
https://doi.org/10.1158/2159-8290.c.6548299.v1
https://doi.org/10.1158/2159-8290.c.6548299.v1
Autor:
Richard B. Pearson, Ross D. Hannan, Grant A. McArthur, Ricky W. Johnstone, Sean O'Brien, Denis Drygin, Jian Kang, Elaine Sanij, Gretchen Poortinga, Megan J. Bywater, Jake Shortt, Amee J. George, Pui Yee Ng, Eric Kusnadi, Carleen Cullinane, Nadine Hein, Katherine M. Hannan, Jennifer R. Devlin
This figure shows supplementary data pertinent to Figure 1 including cell death, cell signalling and mRNA transcription analysis data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f00c09f22ecead59d5a70462dd77357
https://doi.org/10.1158/2159-8290.22530959.v1
https://doi.org/10.1158/2159-8290.22530959.v1