Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ross Cagan"'
Autor:
Ross Cagan, Kevan Shokat
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/61eba61902a64586ac1e1c4e5256f4c0
Autor:
Zhaoping Xiong, Minji Jeon, Robert J Allaway, Jaewoo Kang, Donghyeon Park, Jinhyuk Lee, Hwisang Jeon, Miyoung Ko, Hualiang Jiang, Mingyue Zheng, Aik Choon Tan, Xindi Guo, Multi-Targeting Drug DREAM Challenge Community, Kristen K Dang, Alex Tropsha, Chana Hecht, Tirtha K Das, Heather A Carlson, Ruben Abagyan, Justin Guinney, Avner Schlessinger, Ross Cagan
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009302 (2021)
A continuing challenge in modern medicine is the identification of safer and more efficacious drugs. Precision therapeutics, which have one molecular target, have been long promised to be safer and more effective than traditional therapies. This appr
Externí odkaz:
https://doaj.org/article/760d14f1687d40cc99f25eb1a90cecb7
Autor:
Marshall Posner, Ross Cagan
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102279- (2021)
Externí odkaz:
https://doaj.org/article/2ce02409495d44b49e44a54ae8a0225a
Autor:
Tirtha K. Das, Jared Gatto, Rupa Mirmira, Ethan Hourizadeh, Dalia Kaufman, Bruce D. Gelb, Ross Cagan
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102306- (2021)
Summary: RASopathies represent a family of mostly autosomal dominant diseases that are caused by missense variants in the rat sarcoma viral oncogene/mitogen activated protein kinase (RAS/MAPK) pathway including KRAS, NRAS, BRAF, RAF1, and SHP2. These
Externí odkaz:
https://doaj.org/article/f4df6e338bf44cc19768215f9a685bac
Autor:
Ross Cagan, Pablo Meyer
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 4, Pp 349-352 (2017)
Cancer therapeutics currently have the lowest clinical trial success rate of all major diseases. Partly as a result of the paucity of successful anti-cancer drugs, cancer will soon be the leading cause of mortality in developed countries. As a diseas
Externí odkaz:
https://doaj.org/article/28f7e8b256f14dbbac81f1d695238309
Autor:
Ross Cagan
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 11, Pp 1241-1244 (2016)
An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a dif
Externí odkaz:
https://doaj.org/article/1296e37e16fd4db2a1adceaf7e9bdb98
Autor:
Jianbo Na, Laura Palanker Musselman, Jay Pendse, Thomas J Baranski, Rolf Bodmer, Karen Ocorr, Ross Cagan
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003175 (2013)
Diets high in carbohydrates have long been linked to progressive heart dysfunction, yet the mechanisms by which chronic high sugar leads to heart failure remain poorly understood. Here we combine diet, genetics, and physiology to establish an adult D
Externí odkaz:
https://doaj.org/article/aa585e4dd82c4bcda7449113b0f59fe9
Autor:
Ross Cagan, Eyal Gottlieb
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 3, Pp 233-233 (2016)
With the untimely death of Marcos Vidal, we have lost a good friend and a creative, brilliant colleague who made important contributions to the field of cancer biology through fruit fly research. Marcos began his research into Drosophila at Ross Caga
Externí odkaz:
https://doaj.org/article/7e95f60aee134c599c6938bade94f8ab
Autor:
Shibo Fu, Ying Yang, Tirtha K. Das, Yun Yen, Bing-sen Zhou, Ming-Ming Zhou, Michael Ohlmeyer, Eric C. Ko, Ross Cagan, Barry S. Rosenstein, Shu-hsia Chen, Johnny Kao
Publikováno v:
PLoS ONE, Vol 7, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/752d1ec08b7541acb828af2ac59337b8
Autor:
Shibo Fu, Ying Yang, Tirtha K Das, Yun Yen, Bing-sen Zhou, Ming-Ming Zhou, Michael Ohlmeyer, Eric C Ko, Ross Cagan, Barry S Rosenstein, Shu-hsia Chen, Johnny Kao
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38465 (2012)
BACKGROUND:Persistence of γ-H2AX after ionizing radiation (IR) or drug therapy is a robust reporter of unrepaired DNA double strand breaks in treated cells. METHODS:DU-145 prostate cancer cells were treated with a chemical library ±IR and assayed f
Externí odkaz:
https://doaj.org/article/bbc32fe02ee7409080cba4863a517cf0