Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ross A. Cardarelli"'
Autor:
Matt R. Kelley, Ross A. Cardarelli, Joshua L. Smalley, Thomas A. Ollerhead, Peter M. Andrew, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss
Publikováno v:
EBioMedicine, Vol 32, Iss , Pp 62-71 (2018)
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic i
Externí odkaz:
https://doaj.org/article/48778aaa8f3145169b545ba38e5c06bc
Autor:
Josephine Ng, Nicholas J. Brandon, Joshua L. Smalley, Qiu Ren, Stephen J. Moss, Georgina Kontou, Jack H. Howden, Ross A. Cardarelli, Catherine Choi, Josef T. Kittler
The K+/Cl– co-transporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl−levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors GABAARs. In accord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7889a3b43ffc335ed77368eb9f53e13b
https://doi.org/10.1101/2020.10.29.360875
https://doi.org/10.1101/2020.10.29.360875
Autor:
Joshua L. Smalley, Peter M. Andrew, Stephen J. Moss, Matt R. Kelley, Tarek Z. Deeb, Thomas A. Ollerhead, Ross A. Cardarelli, Nicholas J. Brandon
Publikováno v:
EBioMedicine, Vol 32, Iss, Pp 62-71 (2018)
EBioMedicine
EBioMedicine
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7b82eca4c78d2007ade07cec0d8503
https://doi.org/10.1016/j.ebiom.2018.05.029
https://doi.org/10.1016/j.ebiom.2018.05.029
Autor:
Hanna Jaaro-Peled, Patricio O'Donnell, Akira Sawa, Elizabeth M. Powell, Ross A. Cardarelli, Rolicia Martin
Publikováno v:
Complex Psychiatry. 4:20-29
A truncated disrupted in schizophrenia 1 (Disc1) gene increases the risk of psychiatric disorders, probably affecting cortical interneurons. Here, we sought to determine whether this cell population is affected in mice carrying a truncated (Disc1) al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55dd28004007d011e2641ef3f36e316
https://doi.org/10.1159/000488030
https://doi.org/10.1159/000488030
Autor:
Karen Jones, Ross A. Cardarelli, Leslie C. Conway, David Baker, Matthew P. Burnham, Tarek Z. Deeb, Stephen J. Moss, Lisa McWilliams, Nicholas J. Brandon, Qi Wang, Yvonne E. Moore, Roland Bürli
Publikováno v:
Journal of Biological Chemistry. 292:21253-21263
K+/Cl− cotransporter 2 (KCC2) is selectively expressed in the adult nervous system and allows neurons to maintain low intracellular Cl− levels. Thus, KCC2 activity is an essential prerequisite for fast hyperpolarizing synaptic inhibition mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbac179cb870d4f07932de04c41b0f59
https://doi.org/10.1074/jbc.m117.817841
https://doi.org/10.1074/jbc.m117.817841
Autor:
Eileen McCall, Anass Jawhari, Anders Gunnarsson, Niek Dekker, Ross A. Cardarelli, Stephen J. Moss, Kelly Garnier, Qi Wang, Stéphane Audebert, Tarek Z. Deeb, Stefan Geschwindner, Matthew P. Burnham, Patrick Schultz, David Baker, Alexandre Frechard, Igor Medina, Morgane Agez, Leslie C. Conway, Nicholas J. Brandon
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-15739-1⟩
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-15739-1⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-15739-1⟩
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-15739-1⟩
KCC2 is a neuron specific K+-Cl− co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia. Despite significant accumulating dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42ab6696e56aecc30330e8e110cb149
http://link.springer.com/article/10.1038/s41598-017-15739-1
http://link.springer.com/article/10.1038/s41598-017-15739-1
Autor:
Shiva K. Tyagarajan, Yasmine Cantaut-Belarif, Ross A. Cardarelli, Deepak Srivastava, Stephen J. Moss, Jayanta Mukherjee, Antoine Triller, Tarek Z. Deeb, Jamie Maguire, Nicholas J. Brandon, Menelas N. Pangalos
Publikováno v:
Proceedings of the National Academy of Sciences. 114:11763-11768
Estrogen plays a critical role in many physiological processes and exerts profound effects on behavior by regulating neuronal excitability. While estrogen has been established to exert effects on dendritic morphology and excitatory neurotransmission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3340ea65e35bf36485525a2d09a10c6
https://doi.org/10.1073/pnas.1705075114
https://doi.org/10.1073/pnas.1705075114
Autor:
Shu Fun Josephine Ng, Jack H. Howden, Christopher E. Bope, Miguel A. Rodriguez Santos, Jake S. Dengler, Matt R. Kelley, Qiu Ren, Paul Davies, Ross A. Cardarelli, Catherine Choi, Josef T. Kittler, Joshua L. Smalley, Stephen J. Moss, Georgina Kontou, Nicholas J. Brandon
Publikováno v:
The Journal of Biological Chemistry
The K+/Cl− cotransporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl− levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric acid receptors (GABAARs). In acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99424a7f43e3b1d015f02bb407fe0519
https://doi.org/10.1016/j.jbc.2021.100364
https://doi.org/10.1016/j.jbc.2021.100364
Autor:
Jayanta, Mukherjee, Ross A, Cardarelli, Yasmine, Cantaut-Belarif, Tarek Z, Deeb, Deepak P, Srivastava, Shiva K, Tyagarajan, Menelas N, Pangalos, Antoine, Triller, Jamie, Maguire, Nicholas J, Brandon, Stephen J, Moss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(44)
Our knowledge of how estrogen signaling can influence inhibitory synaptic transmission is rudimentary and is addressed here. Collectively, our data suggest that estrogen modulates the dynamics of surface GABAA receptors and hence efficacy of synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e07cac15e1645ea7347a80eafc0339b2
https://pubmed.ncbi.nlm.nih.gov/29078280
https://pubmed.ncbi.nlm.nih.gov/29078280
Autor:
Tarek Z. Deeb, Mark E. Duggan, Jamie Maguire, Nicholas J. Brandon, Stephen J. Moss, Liliya Silayeva, Matt R. Kelley, John Dunlop, Sudhir Sivakumaran, Stephen Zicha, Robert J. Mather, Ross A. Cardarelli, Yvonne E. Moore, Jayanta Mukherjee, Danielle H. Morrow
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(21)
GABAAreceptors form Cl−permeable channels that mediate the majority of fast synaptic inhibition in the brain. The K+/Cl−cotransporter KCC2 is the main mechanism by which neurons establish low intracellular Cl−levels, which is thought to enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0dd6f9d7499ff8024bc6dda7edce13
https://pubmed.ncbi.nlm.nih.gov/26019342
https://pubmed.ncbi.nlm.nih.gov/26019342