Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ross A. Bathgate"'
Autor:
Mariana R Melo, Alexander D Wykes, Angela A Connelly, Jaspreet K Bassi, Shane D Cheung, Stuart J McDougall, Clément Menuet, Ross AD Bathgate, Andrew M Allen
Publikováno v:
eLife, Vol 12 (2023)
The pre-Bötzinger complex (preBötC), a key primary generator of the inspiratory breathing rhythm, contains neurons that project directly to facial nucleus (7n) motoneurons to coordinate orofacial and nasofacial activity. To further understand the i
Externí odkaz:
https://doaj.org/article/78edb85389c04ef0887fd55cfac45618
Autor:
Fariha Alam, Tracey A. Gaspari, Barbara K. Kemp-Harper, Edward Low, Aaron Aw, Dorota Ferens, Iresha Spizzo, Ann-Maree Jefferis, Praveen Praveen, Robert E. Widdop, Ross A.D. Bathgate, Mohammed Akhter Hossain, Chrishan S. Samuel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114370- (2023)
The hormone, relaxin (RLX), exerts various organ-protective effects independently of etiology. However, its complex two-chain and three disulphide bonded structure is a limitation to its preparation and affordability. Hence, a single chain-derivative
Externí odkaz:
https://doaj.org/article/5ab983e3650b46eba55d98f76cfcbf69
Autor:
Fabian Bumbak, Miquel Pons, Asuka Inoue, Juan Carlos Paniagua, Fei Yan, Hongwei Wu, Scott A. Robson, Ross A.D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112015- (2023)
Summary: Nuclear magnetic resonance (NMR) studies have revealed that fast methyl sidechain dynamics can report on entropically-driven allostery. Yet, NMR applications have been largely limited to the super-microsecond motional regimes of G protein-co
Externí odkaz:
https://doaj.org/article/e832682210c9421aa7945f05bde3d419
Publikováno v:
IBRO Reports, Vol 8, Iss , Pp 1-10 (2020)
Modern neuroscience utilizes transgenic techniques extensively to study the activity and function of brain neural networks. A key feature of this approach is its compatibility with molecular methods for selective transgene expression in neuronal circ
Externí odkaz:
https://doaj.org/article/14337411d3d745afbe6494b18e5ccd5a
Autor:
Bradley L. Hoare, Shoni Bruell, Ashish Sethi, Paul R. Gooley, Michael J. Lew, Mohammed A. Hossain, Asuka Inoue, Daniel J. Scott, Ross A.D. Bathgate
Publikováno v:
iScience, Vol 11, Iss , Pp 93-113 (2019)
Summary: The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. H2 relaxin is hypothesized to bind to two distinct ECD
Externí odkaz:
https://doaj.org/article/106ae93fb3814699bbd1551cc5a6f606
Autor:
Phillip L. van der Peet, Christian Gunawan, Alaa Abdul-Ridha, Sherie Ma, Daniel J. Scott, Andrew L. Gundlach, Ross A.D. Bathgate, Jonathan M. White, Spencer J. Williams
Publikováno v:
MethodsX, Vol 5, Iss , Pp 257-267 (2018)
Chemogenetics uses engineered proteins that are controlled by small molecule actuators, allowing in vivo functional studies of proteins with temporal and dose control, and include Designer Receptors Exclusively Activated by Designer Drugs (DREADDs).
Externí odkaz:
https://doaj.org/article/d942c1cf12674dec842b64444a935b01
Autor:
Guangyao Lin, Yang Feng, Xiaoqing Cai, Caihong Zhou, Lijun Shao, Yan Chen, Linhai Chen, Qing Liu, Qingtong Zhou, Ross A.D. Bathgate, Dehua Yang, Ming-Wei Wang
Publikováno v:
Molecules, Vol 26, Iss 24, p 7511 (2021)
Relaxin/insulin-like family peptide receptor 3 (RXFP3) belongs to class A G protein-coupled receptor family. RXFP3 and its endogenous ligand relaxin-3 are mainly expressed in the brain with important roles in the regulation of appetite, energy metabo
Externí odkaz:
https://doaj.org/article/468a0e2b14504c3d99e6d0c542bd077f
Autor:
Lisa M. Williams, Xiaoji He, Tasneem M. Vaid, Alaa Abdul‐Ridha, Alice R. Whitehead, Paul R. Gooley, Ross A.D. Bathgate, Spencer J. Williams, Daniel J. Scott
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 1, Pp n/a-n/a (2019)
Abstract α1A‐ and α1B‐adrenoceptors (ARs) are G protein‐coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (C
Externí odkaz:
https://doaj.org/article/b419ae6ece494556af9fcb4e8297bc83
Autor:
Roger Summers, Craig Smith, Michelle Halls, Andrew L. Gundlach, Thomas Dschietzig, Ross A.D. Bathgate, Alexander I. Agoulnik
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Relaxin family peptide receptors (RXFP, nomenclature as agreed by the NC-IUPHAR Subcommittee on Relaxin family peptide receptors [23, 119]) may be divided into two pairs, RXFP1/2 and RXFP3/4. Endogenous agonists at these receptors are heterodimeric p
Autor:
Shalinda J.A. Fernando, Qian Wang, Debbie L. Hay, Ross A.D. Bathgate, Peter R. Shepherd, Kate L. Lee
Publikováno v:
Bioscience Reports. 43
RXFP4 is a G protein–coupled receptor (GPCR) in the relaxin family. It has recently been recognised that this receptor and its cognate ligand INSL5 may have a role in the regulation of food intake, gut motility, and other functions relevant to meta