Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ross A Breckenridge"'
Autor:
Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun
Publikováno v:
PLoS Biology, Vol 11, Iss 9, p e1001666 (2013)
Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, wh
Externí odkaz:
https://doaj.org/article/c94bc252bb4048fdb56691e64de2627d
Autor:
Ross A. Breckenridge
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 1, Iss 1, Pp 29-36 (2014)
Immediately following birth, the mammalian heart switches from generating ATP via glycolysis to β-oxidation of lipid. Coincident with this metabolic remodeling, cardiomyocyte mitosis ceases and regenerative capacity is lost. Recently, our understand
Externí odkaz:
https://doaj.org/article/d6f9e98f48e74ed59807fb5fad602860
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 503-507 (2013)
SUMMARY The pathology of sudden infant death syndrome (SIDS) is poorly understood. Many risk factors, including hypoxia, have been identified. Prolongation of the ECG QTc interval is associated with elevated risk of SIDS but its aetiology in most cas
Externí odkaz:
https://doaj.org/article/a701ea185ca44873b3c754ac6d600968
Autor:
Carl C. Peck, Ross A. Breckenridge
Publikováno v:
Clinical pharmacology and therapeutics. 108(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03a460b65b58eba0d97e58915185456
https://pubmed.ncbi.nlm.nih.gov/32279311
https://pubmed.ncbi.nlm.nih.gov/32279311
Publikováno v:
Br J Clin Pharmacol
Radically expanding use of real-world data (RWD) and real-world evidence (RWE) holds the potential to substantially impact drug development, pharmaceutical regulation, and payment within health care systems. Central to this is the reconfiguration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fc3c901f743d9463dfe612959b96af
https://pubmed.ncbi.nlm.nih.gov/31290181
https://pubmed.ncbi.nlm.nih.gov/31290181
Autor:
Malcolm Finlay, Aaisha Opel, Ross A. Breckenridge, Andrew Tinker, David Montaigne, Naomi Anderson, Muriel Nobles
Publikováno v:
Journal of Biological Chemistry. 290:19233-19244
The description of potential molecular substrates for predisposition to atrial fibrillation (AF) is incomplete, and it is unknown what role regulators of G-protein signaling might play. We address whether the attenuation of RGS4 function may promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6c574a8490aefc3513ac3e92b26bc2
https://doi.org/10.1074/jbc.m115.666719
https://doi.org/10.1074/jbc.m115.666719
Publikováno v:
The Lancet Respiratory Medicine. 4:601-603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f30a95af465e18941e371a355da827
https://doi.org/10.1016/s2213-2600(16)30118-7
https://doi.org/10.1016/s2213-2600(16)30118-7
Autor:
Franklyn B. Garry, Joseph M. Neary, Timothy N. Holt, Timothy J. Mohun, Marianne T. Neary, Ross A. Breckenridge, Gretchen K. Lund
Publikováno v:
Pulmonary Circulation. 4:496-503
Bovine pulmonary hypertension, brisket disease, causes significant morbidity and mortality at elevations above 2,000 m. Mean pulmonary arterial pressure (mPAP) is moderately heritable, with inheritance estimated to lie within a few major genes. Invas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d06fb4da7b9ca772f9238faf3a5708f
https://doi.org/10.1086/677364
https://doi.org/10.1086/677364
Autor:
Ross A. Breckenridge, Gregory I. Mashanov, Nigel J. M. Birdsall, Tatiana A. Nenasheva, Justin E. Molloy, Marianne T. Neary
Publikováno v:
Journal of Molecular and Cellular Cardiology. 57:129-136
M2 muscarinic acetylcholine receptors modulate cardiac rhythm via regulation of the inward potassium current. To increase our understanding of M2 receptor physiology we used Total Internal Reflection Fluorescence Microscopy to visualize individual re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78af21ec4c39443fe64d2b283128313b
https://doi.org/10.1016/j.yjmcc.2013.01.009
https://doi.org/10.1016/j.yjmcc.2013.01.009
Autor:
Laurent Dupays, Nicola Smart, Catherine A. Risebro, Paul R. Riley, Ross A. Breckenridge, Timothy J. Mohun
The precise origins of myocardial progenitors and their subsequent contribution to the developing heart has been an area of considerable activity within the field of cardiovascular biology. How these progenitors are regulated and what signals are res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9724e4583018d87c1f80d7525b52c7
https://doi.org/10.1242/dev.02625
https://doi.org/10.1242/dev.02625
