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Genetic Markers of Toxicity From Capecitabine and Other Fluorouracil-Based Regimens: Investigation in the QUASAR2 Study, Systematic Review, and Meta-Analysis

Autor: Sargent, Daniel, Gonzalez-Neira, Anna, Johnstone, Elaine, Seymour, Matthew, Schwab, Matthias, Boige, Valérie, Milano, Gérard, Nicholson, George, Zanger, Ulrich M., Green, Erin, Scudder, Claire, Jensen, Søren Astrup, Wadelius, Mia, Lacas, Benjamin, Garmo, Hans, Martin, Miguel, Love, Sharon, Afzal, Shoaib, Ribelles, Nuria, Thompson, Lindsay, Enghusen, Henrik, McLeod, Howard, Church, David, Palles, Claire, Glimelius, Bengt, Wang, Haitao, Domingo, Enric, Braun, Michael, Rosmarin, Dan, Etienne-Grimaldi, Marie-Christine, Jones, Angela, Julier, Patrick

Fluourouracil (FU) is a mainstay of chemotherapy, although toxicities are common. Genetic biomarkers have been used to predict these adverse events, but their utility is uncertain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da8aaed4dd034080df2e141831b2fd3e

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Germline determinants of 5-fluorouracil drug toxicity and patient survival in colorectal cancer

Autor: Rosmarin, Daniel Norris

Despite a decade of publications investigating the effect of germline polymorphisms on both toxicity related to treatment with 5-fluorouracil-based (5-FU) chemotherapy and prognosis following diagnosis with colorectal cancer (CRC), few genetic biomar

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618394

A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.

Autor: Rosmarin D; Molecular and Population Genetics Laboratory, Oxford, UK Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK., Palles C; Molecular and Population Genetics Laboratory, Oxford, UK., Pagnamenta A; Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK., Kaur K; Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK., Pita G; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid, Spain., Martin M; Department of Medical Oncology, Instituto de Investigacion Sanitaria Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain., Domingo E; Molecular and Population Genetics Laboratory, Oxford, UK Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK., Jones A; Molecular and Population Genetics Laboratory, Oxford, UK., Howarth K; Molecular and Population Genetics Laboratory, Oxford, UK., Freeman-Mills L; Molecular and Population Genetics Laboratory, Oxford, UK., Johnstone E; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK., Wang H; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK., Love S; Centre for Statistics in Medicine, University of Oxford, Botnar Research Centre, Oxford, UK., Scudder C; OCTO, University of Oxford, Old Road Campus Research Building, Oxford, UK., Julier P; OCTO, University of Oxford, Old Road Campus Research Building, Oxford, UK., Fernández-Rozadilla C; Molecular and Population Genetics Laboratory, Oxford, UK., Ruiz-Ponte C; Galician Public Foundation of Genomic Medicine (FPGMX), CIBERER, Genomics Medicine Group, Hospital Clinico, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain., Carracedo A; Galician Public Foundation of Genomic Medicine (FPGMX), CIBERER, Genomics Medicine Group, Hospital Clinico, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain., Castellvi-Bel S; Genetic Susceptibility to Colorectal Cancer Group, Gastrointestinal & Pancreatic Oncology Team, IDIBAPS/CIBERehd/Hospital Clínic, Centre Esther Koplowitz (CEK), Barcelona, Spain., Castells A; Institute of Digestive and Metabolic Diseases, Hospital Clínic, Barcelona, Spain., Gonzalez-Neira A; Human Genotyping Unit-CeGen, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, Madrid, Spain., Taylor J; Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK., Kerr R; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK., Kerr D; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK., Tomlinson I; Molecular and Population Genetics Laboratory, Oxford, UK Oxford NIHR Comprehensive Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK.

Publikováno v: Gut [Gut] 2015 Jan; Vol. 64 (1), pp. 111-20. Date of Electronic Publication: 2014 Mar 19.