Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Roslyn N. Brown"'
Autor:
Ryan L. Sontag, Ernesto S. Nakayasu, Roslyn N. Brown, George S. Niemann, Michael A. Sydor, Octavio Sanchez, Charles Ansong, Shao-Yeh Lu, Hyungwon Choi, Dylan Valleau, Karl K. Weitz, Alexei Savchenko, Eric D. Cambronne, Joshua N. Adkins
Publikováno v:
mSystems, Vol 1, Iss 4 (2016)
ABSTRACT Many pathogenic bacteria of the family Enterobacteriaceae use type III secretion systems to inject virulence proteins, termed “effectors,” into the host cell cytosol. Although host-cellular activities of several effectors have been demon
Externí odkaz:
https://doaj.org/article/f78a2ab44ff5495684196c96fa5db218
Autor:
Samuel H. Payne, Stefano Bonissone, Si Wu, Roslyn N. Brown, Dmitry N. Ivankov, Dmitrij Frishman, Ljiljana Paša-Tolić, Richard D. Smith, Pavel A. Pevzner
Publikováno v:
mBio, Vol 3, Iss 6 (2012)
ABSTRACT Signal peptides are a cornerstone mechanism for cellular protein localization, yet until now experimental determination of signal peptides has come from only a narrow taxonomic sampling. As a result, the dominant view is that Sec-cleaved sig
Externí odkaz:
https://doaj.org/article/d97b16dedef64b4e89c86a8a1c5f39b4
Autor:
Afshan S Kidwai, Ivy Mushamiri, George S Niemann, Roslyn N Brown, Joshua N Adkins, Fred Heffron
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70753 (2013)
Salmonella enterica serovar Typhimurium causes typhoid-like disease in mice and is a model of typhoid fever in humans. One of the hallmarks of typhoid is persistence, the ability of the bacteria to survive in the host weeks after infection. Virulence
Externí odkaz:
https://doaj.org/article/35c4c09bb2c4441d9db5e90f1918d1c5
Autor:
Jie Li, Rosa Di Leo, Tiago J. P. Sobreira, Michael A. Sydor, Gordon W. Slysz, Olena Onoprienko, Ernesto S. Nakayasu, Brooke L. Deatherage Kaiser, Charles Ansong, Tatiana Skarina, Joshua N. Adkins, Eric D. Cambronne, Daniel R. Humphrys, Richard D. Smith, Roslyn N. Brown, Alexei Savchenko, Ryan L. Sontag
Publikováno v:
Journal of Proteome Research. 14:4029-4038
Ubiquitination is a key protein post-translational modification that regulates many important cellular pathways and whose levels are regulated by equilibrium between the activities of ubiquitin ligases and deubiquitinases. Here, we present a method t
Autor:
Richard D. Smith, Renuka Bhattacharya, John D. Sandoval, Kevin L. Crowell, Deborah L. Diamond, Steven G. Self, Gordon W. Slysz, Kristin E. Burnum-Johnson, Yehia M. Ibrahim, Susan Strom, William F. Danielson, Paul D. Piehowski, Daniel J. Orton, Marina A. Gritsenko, Brian L. LaMarche, Brian J. McMahon, Matthew E. Monroe, Brenna C. Simons, Robert L. Carithers, Melissa M. Matzke, Ronald J. Moore, David E. Purdy, Roslyn N. Brown, James D. Perkins, Jon M. Jacobs, Erin S. Baker, Gordon A. Anderson, Bobbie-Jo M. Webb-Robertson, Michael G. Katze
Publikováno v:
Molecular & Cellular Proteomics. 13:1119-1127
Rapid diagnosis of disease states using less invasive, safer, and more clinically acceptable approaches than presently employed is a crucial direction for the field of medicine. While MS-based proteomics approaches have attempted to meet these object
Autor:
Ryan L, Sontag, Ernesto S, Nakayasu, Roslyn N, Brown, George S, Niemann, Michael A, Sydor, Octavio, Sanchez, Charles, Ansong, Shao-Yeh, Lu, Hyungwon, Choi, Dylan, Valleau, Karl K, Weitz, Alexei, Savchenko, Eric D, Cambronne, Joshua N, Adkins
Publikováno v:
mSystems
During infection, pathogenic bacteria face an adverse environment of factors driven by both cellular and humoral defense mechanisms. To help evade the immune response and ultimately proliferate inside the host, many bacteria evolved specialized secre
Autor:
Haizhen, Zhang, Feng, Yang, Wei-Jun, Qian, Roslyn N, Brown, Yuexi, Wang, Eric D, Merkley, Eric E, Merkley, Jea H, Park, Matthew E, Monroe, Samuel O, Purvine, Ronald J, Moore, Liang, Shi, James K, Fredrickson, Ljiljana, Paša-Tolić, Richard D, Smith, Mary S, Lipton
Publikováno v:
Analytical Chemistry. 83:7260-7268
The c-type cytochromes play essential roles in many biological activities of both prokaryotic and eukaryotic cells, including electron transfer, enzyme catalysis, and induction of apoptosis. We report a novel enrichment strategy for identifying c-typ
Publikováno v:
Journal of Proteome Research. 9:4454-4463
A simple and effective subcellular proteomic method for fractionation based on osmotic lysis, differential centrifugation, and Sarkosyl solubilization was applied to the Gram-negative bacterium Shewanella oneidensis to gain insight into its subcellul
Publikováno v:
Applied and Environmental Microbiology. 75:4936-4949
Vibrio vulnificus is a bacterial contaminant of shellfish and causes highly lethal sepsis and destructive wound infections. A definitive identification of virulence factors using the molecular version of Koch's postulates has been hindered because of
Autor:
Cosmin Mihai, Joshua N. Adkins, Roslyn N. Brown, Tatiana Skarina, Hong Cui, John R. Cort, Ryan L. Sontag, Alexei Savchenko, Galya Orr
Publikováno v:
Journal of Visualized Experiments.
The study of protein interactions in the context of living cells can generate critical information about localization, dynamics, and interacting partners. This information is particularly valuable in the context of host-pathogen interactions. Many pa