Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.

Autor: Paparin JL; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France. Electronic address: jean-laurent.paparin@merck.com., Amador A; Former Idenix employee., Badaroux E; Former Idenix employee., Bot S; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France., Caillet C; Former Idenix employee., Convard T; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France., Da Costa D; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France., Dukhan D; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France., Griffe L; Former Idenix employee., Griffon JF; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France., LaColla M; Former Idenix employee., Leroy F; Former Idenix employee., Liuzzi M; Former Idenix employee., Giulia Loi A; Former Idenix employee., McCarville J; Former Idenix employee., Mascia V; Former Idenix employee., Milhau J; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France., Onidi L; Former Idenix employee., Pierra C; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France., Rahali R; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France., Rosinosky E; Former Idenix employee., Sais E; Former Idenix employee., Seifer M; Former Idenix employee., Surleraux D; Former Idenix employee., Standring D; Former Idenix employee., Dousson CB; Idenix SARL, an MSD Company, Medicinal Chemistry Laboratory, Cap Gamma, 1682 rue de la Valsière, BP50001, 34189 Montpellier Cedex 4, France.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 01; Vol. 27 (11), pp. 2634-2640. Date of Electronic Publication: 2017 Jan 13.

Organophosphorus Chemistry : Volume 48

Autor: David W Allen, David Loakes, John C Tebby

This annual review of the literature presents a comprehensive and critical survey of the vast field of study involving organophosphorus compounds, from phosphines and related P-C bonded compounds to phosphorus acids, phosphine chalcogenides and nucle