Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rosina Savisaar"'
Autor:
Noélia Custódio, Rosina Savisaar, Célia Carvalho, Pedro Bak-Gordon, Maria I. Ribeiro, Joana Tavares, Paula B. Nunes, Ana Peixoto, Carla Pinto, Carla Escudeiro, Manuel R. Teixeira, Maria Carmo-Fonseca
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 199 (2022)
Predictive biomarkers are crucial in clarifying the best strategy to use poly(ADP-ribose) polymerase inhibitors (PARPi) for the greatest benefit to ovarian cancer patients. PARPi are specifically lethal to cancer cells that cannot repair DNA damage b
Externí odkaz:
https://doaj.org/article/35fd3c7193d046c8884b97ed420fee1b
The adoption of whole genome sequencing in genetic screens has facilitated the detection of genetic variation in the intronic regions of genes, far from annotated splice sites. However, selecting an appropriate computational tool to differentiate fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca4ff5fbde192d11d9064c920dd5bef
https://doi.org/10.1101/2023.02.17.528928
https://doi.org/10.1101/2023.02.17.528928
Autor:
Noélia, Custódio, Rosina, Savisaar, Célia, Carvalho, Pedro, Bak-Gordon, Maria I, Ribeiro, Joana, Tavares, Paula B, Nunes, Ana, Peixoto, Carla, Pinto, Carla, Escudeiro, Manuel R, Teixeira, Maria, Carmo-Fonseca
Publikováno v:
Biomedicines. 10(2)
Predictive biomarkers are crucial in clarifying the best strategy to use poly(ADP-ribose) polymerase inhibitors (PARPi) for the greatest benefit to ovarian cancer patients. PARPi are specifically lethal to cancer cells that cannot repair DNA damage b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16d753df6bfab4ecb977f2c99c1d85d5
https://pubmed.ncbi.nlm.nih.gov/35203410
https://pubmed.ncbi.nlm.nih.gov/35203410
Autor:
Pedro, Prudêncio, Rosina, Savisaar, Kenny, Rebelo, Rui Gonçalo, Martinho, Maria, Carmo-Fonseca
Publikováno v:
RNA (New York, N.Y.). 28(2)
Widespread cotranscriptional splicing has been demonstrated from yeast to human. However, most studies to date addressing the kinetics of splicing relative to transcription used either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54e7187854774e4abb9fd4309afbd447
https://pubmed.ncbi.nlm.nih.gov/34667107
https://pubmed.ncbi.nlm.nih.gov/34667107
Autor:
Grzegorz Kudla, Liam Abrahams, Laurence D. Hurst, Rosina Savisaar, Bethan Young, Christine Mordstein
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Abrahams, L, Savisaar, R, Mordstein, C, Young, B, Kudla, G & Hurst, L D 2021, ' Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption ', Nucleic Acids Research, vol. 49, no. 17, pp. 9665-9685 . https://doi.org/10.1093/nar/gkab750
Nucleic Acids Research
Abrahams, L, Savisaar, R, Mordstein, C, Young, B, Kudla, G & Hurst, L 2021, ' Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption ', Nucleic Acids Research, vol. 49, no. 17, pp. 9665-9685 . https://doi.org/10.1093/nar/gkab750
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Abrahams, L, Savisaar, R, Mordstein, C, Young, B, Kudla, G & Hurst, L D 2021, ' Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption ', Nucleic Acids Research, vol. 49, no. 17, pp. 9665-9685 . https://doi.org/10.1093/nar/gkab750
Nucleic Acids Research
Abrahams, L, Savisaar, R, Mordstein, C, Young, B, Kudla, G & Hurst, L 2021, ' Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption ', Nucleic Acids Research, vol. 49, no. 17, pp. 9665-9685 . https://doi.org/10.1093/nar/gkab750
© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb41ee3aeb468d8ff8d56d0778369f68
https://hdl.handle.net/10451/49552
https://hdl.handle.net/10451/49552
Widespread co-transcriptional splicing has been demonstrated from yeast to human. However, most studies to date addressing the kinetics of splicing relative to transcription used either Saccharomyces cerevisiae or metazoan cultured cell lines. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a8721277886641235345db4c6b20c9b
https://doi.org/10.1101/2020.11.05.367888
https://doi.org/10.1101/2020.11.05.367888
Autor:
Grzegorz Kudla, Rosina Savisaar, Lana Talmane, Christine Mordstein, Jeanne Bazile, Martin S. Taylor, Laurence D. Hurst, Michael Liss, Robert Young, Juliet Luft
Publikováno v:
Mordstein, C, Savisaar, R, Young, R S, Bazile, J, Talmane, L, Luft, J, Liss, M, Taylor, M S, Hurst, L D & Kudla, G 2020, ' Codon Usage and Splicing Jointly Influence mRNA Localization ', Cell Systems, vol. 10, no. 4, pp. 351-362.e8 . https://doi.org/10.1016/j.cels.2020.03.001
Cell Systems
Cell Systems
Summary In the human genome, most genes undergo splicing, and patterns of codon usage are splicing dependent: guanine and cytosine (GC) content is the highest within single-exon genes and within first exons of multi-exon genes. However, the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ceab45f0d3e54449703eaf47c1197e
https://hdl.handle.net/20.500.11820/ba69cc6e-29b6-443c-8791-ce9e07eac2a9
https://hdl.handle.net/20.500.11820/ba69cc6e-29b6-443c-8791-ce9e07eac2a9
Autor:
Laurence D. Hurst, Rosina Savisaar, Martin S. Taylor, Michael Liss, Robert Young, Lana Talmane, Jeanne Bazile, Grzegorz Kudla, Juliet Luft, Christine Mordstein
Although multiple studies have addressed the effects of codon usage on gene expression, such studies were typically performed in unspliced model genes. In the human genome, most genes undergo splicing and patterns of codon usage are splicing-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e1e30e84450f6017825c7d8d701c6c
https://doi.org/10.1101/527440
https://doi.org/10.1101/527440
Autor:
Alexandre E. Peluffo, Jean R. David, Daniel R. Matute, Amir Yassin, Virginie Courtier-Orgogozo, David L. Stern, Rosina Savisaar, Michael Lang, Olga Nagy, Isabelle Nuez
Publikováno v:
Current Biology-CB
Current Biology-CB, Elsevier, 2018, 28, pp.1-7
HAL
Current Biology-CB, Elsevier, 2018, 28, pp.1-7
HAL
Diverse traits often covary between species [1-3]. The possibility that a single mutation could contribute to the evolution of several characters between species [3] is rarely investigated as relatively few cases are dissected at the nucleotide level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6482c1f5619ad3fb7eb73b2efc0332ce
https://hal.archives-ouvertes.fr/hal-03450814
https://hal.archives-ouvertes.fr/hal-03450814
Autor:
Amir Yassin, Virginie Courtier-Orgogozo, David L. Stern, Rosina Savisaar, Olga Nagy, Isabelle Nuez, Jean R. David, Daniel R. Matute, Michael Lang, Alexandre E. Peluffo
Diverse traits often covary between species. The possibility that a single mutation could contribute to the evolution of several characters between species is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269c948fbb3942752c863cdce6564552