Amiodarone hydrochloride: enhancement of solubility and dissolution rate by solid dispersion technique

Autor: Clarice Madalena Bueno Rolim, Alexandre Machado Rubim, Luciane Varini Laporta, Rosimar Leitenberg, Jaqueline Bandeira Rubenick, Eduarda Gregolin

Publikováno v: Brazilian Journal of Pharmaceutical Sciences; Vol. 51 No. 4 (2015); 957-966
Brazilian Journal of Pharmaceutical Sciences; Vol. 51 Núm. 4 (2015); 957-966
Brazilian Journal of Pharmaceutical Sciences; v. 51 n. 4 (2015); 957-966
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Vol 51, Iss 4, Pp 957-966 (2015)
Brazilian Journal of Pharmaceutical Sciences, Volume: 51, Issue: 4, Pages: 957-966, Published: DEC 2015

Amiodarone HCl is an antiarrhythmic agent, which has low aqueous solubility and presents absorption problems. This study aimed to develop inclusion complexes containing hydrophilic carriers PEG 1500, 4000 and 6000 by fusion and kneading methods in or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee562fb4e16f97196e0eb48d7498dc5
https://www.revistas.usp.br/bjps/article/view/118649