Normality sensing licenses local T cells for innate-like tissue surveillance

Autor: Duncan R. McKenzie, Rosie Hart, Nourdine Bah, Dmitry S. Ushakov, Miguel Muñoz-Ruiz, Regina Feederle, Adrian C. Hayday

Publikováno v: Nature Immunology. 23:411-422

The increasing implication of lymphocytes in general physiology and immune surveillance outside of infection poses the question of how their antigen receptors might be involved. Here, we show that macromolecular aggregates of intraepidermal γδ T ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f7e8c8326a35fc3480baed6df00b93
https://doi.org/10.1038/s41590-021-01124-8

Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5

Autor: Rosie Hart, David R. Greaves

Chemerin is a potent macrophage chemoattractant protein. We used murine peritoneal exudate cells (PECs) in adhesion, flow cytometry, and confocal microscopy assays to test the hypothesis that chemerin can also contribute to inflammation by promoting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98197a08d211d2c58a959c94b5dd0d3
https://ora.ox.ac.uk/objects/uuid:bdaccba8-17b6-4256-972c-1de0c40eccee

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

Autor: Deena L. Gibbons, Sara Cipolat, Ulrich Steinhoff, Livija Deban, Adam Laing, Oliver Nussbaumer, Philip East, Robin J. Dart, Natalie A. Roberts, Adrian Hayday, Rosie Hart, Peter M. Irving, Anett Jandke, Rafael Di Marco Barros, Maria Luisa Iannitto, Bradley Spencer-Dene, Pablo Pereira, Pierre Vantourout

Publikováno v: Cell
Cell, 2016, 167 (1), pp.203-218.e17. ⟨10.1016/j.cell.2016.08.030⟩
Di Marco Barros, R, Roberts, NA, Dart, RJ, Vantourout, P, Jandke, A, Nussbaumer, O, Deban, L, Cipolat, S, Hart, R, Iannitto, M, Laing, A, Spencer-Dene, B, East, P, Gibbons, D, Irving, PM, Pereira, P, Steinhoff, U & Hayday, A 2016, ' Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments ', Cell, vol. 167, no. 1, pp. 203-218.e17 . https://doi.org/10.1016/j.cell.2016.08.030
Cell, Elsevier, 2016, 167 (1), pp.203-218.e17. ⟨10.1016/j.cell.2016.08.030⟩

Summary Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vγ5 chains protect from cutaneous carcinogens.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf033ca259bbcccfe546416e856c12f1