Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Roshni V. Madhvani"'
Autor:
Jan P. Kucera, James N. Weiss, Marina Angelini, Yann Prudat, Riccardo Olcese, Enno de Lange, Alan Garfinkel, Roshni V. Madhvani, Nils P. Borgstom, Hrayr S. Karagueuzian
Publikováno v:
The Journal of Physiology. 594:2537-2553
Key points Beat-to-beat alternation (alternans) of the cardiac action potential duration is known to precipitate life-threatening arrhythmias and can be driven by the kinetics of voltage-gated membrane currents or by instabilities in intracellular ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a06004ffce0dcca373fcd8e3b5728ea4
https://doi.org/10.1113/jp271573
https://doi.org/10.1113/jp271573
Autor:
Yann, Prudat, Roshni V, Madhvani, Marina, Angelini, Nils P, Borgstom, Alan, Garfinkel, Hrayr S, Karagueuzian, James N, Weiss, Enno, de Lange, Riccardo, Olcese, Jan P, Kucera
Publikováno v:
The Journal of physiology
Beat-to-beat alternation (alternans) of the cardiac action potential duration is known to precipitate life-threatening arrhythmias and can be driven by the kinetics of voltage-gated membrane currents or by instabilities in intracellular calcium fluxe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20641181206e52c0f74547f6fb285809
Autor:
Riccardo Olcese, Roshni V. Madhvani, James N. Weiss, Zhilin Qu, Marina Angelini, Silvie Suriany, Antonios Pantazis, Alan Garfinkel, Yuanfang Xie, N.P. Borgstrom
Publikováno v:
The Journal of General Physiology
The Journal of general physiology, vol 145, iss 5
The Journal of general physiology, vol 145, iss 5
Decreasing the amplitude of the late component of the cardiac L-type Ca2+ channel current suppresses early afterdepolarizations, thereby decreasing the risk of arrhythmias.
Early afterdepolarizations (EADs) associated with prolongation of the ca
Early afterdepolarizations (EADs) associated with prolongation of the ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc4db3f47cd8dd85c26b87d56f701bf
http://europepmc.org/articles/PMC4411259
http://europepmc.org/articles/PMC4411259
Autor:
Antonios Pantazis, Riccardo Olcese, Roshni V. Madhvani, Zhilin Qu, James N. Weiss, Alan Garfinkel, Yuanfang Xie
Publikováno v:
The Journal of Physiology. 589:6081-6092
Sudden cardiac death (SCD) due to ventricular fibrillation (VF) is a major world-wide health problem. A common trigger of VF involves abnormal repolarization of the cardiac action potential causing early afterdepolarizations (EADs). Here we used a hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b46843ed107dc663819c1a4a999362
https://doi.org/10.1113/jphysiol.2011.219600
https://doi.org/10.1113/jphysiol.2011.219600
Autor:
James N. Weiss, Antonios Pantazis, Zhilin Qu, Riccardo Olcese, Roshni V. Madhvani, Alan Garfinkel, Yuanfang Xie
Publikováno v:
Biophysical Journal. 104(2)
Early afterdepolarizations (EADs) are highly arrhythmogenic transient depolarizations occurring during phase 2 or 3 of the cardiac action potential. We recently reported that EADs are highly sensitive to minimal shifts (by 1-5 mV) in the half activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4af0b77071661678e17e6eaae3114c
Publikováno v:
Biochemistry. 45(13)
To complete a study on site-directed alkylation of Cys replacements in the lactose permease of Escherichia coli (LacY), the reactivity of single-Cys mutants in helices I, III, VI, and XI, as well as some of the adjoining loops, with N-[ 14 C]ethylmal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46d1a0c940dd2d0def14c43e42fa53f
https://pubmed.ncbi.nlm.nih.gov/16566592
https://pubmed.ncbi.nlm.nih.gov/16566592
Autor:
Riccardo Olcese, Yuanfang Xie, Alan Garfinkel, Roshni V. Madhvani, James N. Weiss, Zhilin Qu, Antonios Pantazis
Publikováno v:
Biophysical Journal. 102:541a
Early afterdepolarizations (EADs) are transient reversals of repolarization that are known triggers for fatal cardiac arrhythmias such as ventricular fibrillation. Our previous work, using dynamic clamp, demonstrated that EADs are very sensitive to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a793a49f0accb2f571ec503da6f27a
https://doi.org/10.1016/j.bpj.2011.11.2956
https://doi.org/10.1016/j.bpj.2011.11.2956
Autor:
Roshni V. Madhvani, James N. Weiss, Yuanfang Xie, Riccardo Olcese, Zhilin Qu, Antonios Pantazis, Alan Garfinkel
Publikováno v:
Biophysical Journal. 100:439a
Early afterdepolarizations (EADs) are highly arrhythmogenic alterations of the cardiac action potential (AP) characterized as transient reversals of repolarization during AP phase 2 or 3. Using the dynamic clamp technique, we combined mathematical mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dd0b31f406e07db4306832af018f2d
https://doi.org/10.1016/j.bpj.2010.12.2584
https://doi.org/10.1016/j.bpj.2010.12.2584
Publikováno v:
Biophysical Journal. (2):535a
The voltage- and calcium-activated BK channel (Slo1) is modulated by small ligands that bind to its intracellular gating ring (GR) formed by four pairs of tandem homologous RCK1 and RCK2 domains. Heme binds reversibly to the GR at site 612CKACH616, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5f2569750f6b06d825d8a714642efa