Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development

Autor: King Hang Tommy Mau, Donja Karimlou, David Barneda, Vincent Brochard, Christophe Royer, Bryony Leeke, Roshni A. de Souza, Mélanie Pailles, Michelle Percharde, Shankar Srinivas, Alice Jouneau, Mark Christian, Véronique Azuara

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Prior to its implantation into the uterus, the mammalian embryo stores substantial lipids. Here the authors unveil how lipid storage and morphogenesis of pluripotent stem cells are fundamentally connected during peri-implantation development.

Externí odkaz: https://doaj.org/article/bb72511e0105419db55b4a16833beed1

Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency

Autor: Edward Curry, Véronique Azuara, King Hang T. Mau, Roshni A. de Souza, Vincent Brochard, Alice Jouneau, Rute A. Tomaz, Luc Jouneau, Wout Megchelenbrink, Emma Bell, Hendrik Marks, Yaser Atlasi, Hendrik G. Stunnenberg

Publikováno v: 3rd Annual Meeting
3rd Annual Meeting, Nov 2019, Lyon, France
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-14916-7⟩
www.nature.com
3rd Annual Meeting, French Society for Stem Cell Research. Corbeil-Essonne, FRA., Nov 2019, Lyon, France
Nature Communications, 11, 1
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, 11
Nature Communications 1 (11), . (2020)

Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood. Here, we report the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046c04223cda3855ff63c5fe907d1490
https://www.repository.cam.ac.uk/handle/1810/304967