Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Roshini, Markandu"'
Autor:
Edward J. Hennessy, Marianne Schimpl, Emma Rivers, Paul D. Smith, Elizabeth Hardaker, Ann T. Doherty, Nichola L. Davies, Jon Travers, Qianxiu Zhu, Beth Williamson, Graham Smith, Lorraine Mooney, Helen Musgrove, Kristin Goldberg, Muireann Coen, Anne-Laure Lainé, Xiefeng Jiang, Philip Hopcroft, Yuting Zheng, Robert I Troup, George Hodgson, Nicola Lindsay, Lindsay McMurray, Olga Collingwood, Stephen D. Wilkinson, Sharon Tentarelli, Guang He, Philip B. Rawlins, Roshini Markandu, Jon Winter-Holt, Josephine Walton, Ankur Karmokar, J. Willem M. Nissink, Yumeng Mao, Dejian Yang, Alexander Pflug, Gary Fairley, Scott Boyd, Cheng Wang, Anne Jackson, Martin R. Brown, William McCoull, Neville McLean, Venkatesh Pilla Reddy
Publikováno v:
Journal of Medicinal Chemistry. 64:13524-13539
Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor microenvironment. Highly selective dual Mer/Axl kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae4c719e098004f12a5992670f8e8abc
https://doi.org/10.1021/acs.jmedchem.1c00920
https://doi.org/10.1021/acs.jmedchem.1c00920
Autor:
William, McCoull, Scott, Boyd, Martin R, Brown, Muireann, Coen, Olga, Collingwood, Nichola L, Davies, Ann, Doherty, Gary, Fairley, Kristin, Goldberg, Elizabeth, Hardaker, Guang, He, Edward J, Hennessy, Philip, Hopcroft, George, Hodgson, Anne, Jackson, Xiefeng, Jiang, Ankur, Karmokar, Anne-Laure, Lainé, Nicola, Lindsay, Yumeng, Mao, Roshini, Markandu, Lindsay, McMurray, Neville, McLean, Lorraine, Mooney, Helen, Musgrove, J Willem M, Nissink, Alexander, Pflug, Venkatesh Pilla, Reddy, Philip B, Rawlins, Emma, Rivers, Marianne, Schimpl, Graham F, Smith, Sharon, Tentarelli, Jon, Travers, Robert I, Troup, Josephine, Walton, Cheng, Wang, Stephen, Wilkinson, Beth, Williamson, Jon, Winter-Holt, Dejian, Yang, Yuting, Zheng, Qianxiu, Zhu, Paul D, Smith
Publikováno v:
Journal of medicinal chemistry. 64(18)
Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor microenvironment. Highly selective dual Mer/Axl kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ae60041f0f2dfe86225bfbc9ef0aea3
https://pubmed.ncbi.nlm.nih.gov/34478292
https://pubmed.ncbi.nlm.nih.gov/34478292
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(9)
Inconsistencies in pharmacokinetic parameters between individual animals in preclinical studies are a common occurrence. Often such differences between animals are simply accepted as experimental variability rather than as indications of specific dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15eb4c4d7f541611f30afba9954efd59
https://pubmed.ncbi.nlm.nih.gov/34135088
https://pubmed.ncbi.nlm.nih.gov/34135088
Publikováno v:
Rapid Communications in Mass Spectrometry. 34
Rationale To capture all metabolites in metabolite identification studies, MS/MS information is required in both positive and negative ionization mode, usually involving several sample injections to gain all information about samples. A high-resoluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1912d102c41b99a953fb8ab18100d756
https://doi.org/10.1002/rcm.8735
https://doi.org/10.1002/rcm.8735
Autor:
Roshini Markandu, Barry Jones, Tashinga E. Bapiro, Venkatesh Pilla Reddy, Adrian J. Fretland, Alexandra L. Orton
Identification of the enzymes responsible for the metabolism of drugs entering the clinic is an important activity of a drug metabolism scientist. This activity forms the basis of important risk assessment for drug-drug interactions (DDIs) for new mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e50eb495e69b070c2f0c2f59936716e
https://doi.org/10.1016/b978-0-12-820018-6.00007-7
https://doi.org/10.1016/b978-0-12-820018-6.00007-7
Autor:
Farah Al Qaraghuli, Ravindra Varma Alluri, Sophie M.A. Argon, Piyush Bajaj, Tashinga E. Bapiro, Abdul Basit, Andreas Brink, Tingting Cai, Jose Castro-Perez, Jae H. Chang, Eugene Chia-Te Chen, Marie Croft, Liam Evans, Raymond Evers, Robert S. Foti, Adrian J. Fretland, Christopher Gemski, Anima Ghosal, Jia Hao, Satyajeet Haridas, Simon Hauri, Nina Isoherranen, Wenying Jian, Kevin Johnson, Barry Jones, Robert S. Jones, Jan Felix Joseph, S. Cyrus Khojasteh, Yurong Lai, Hoa Le, Xiaomin Liang, Liming Liu, Filipe Lopes, Justin Q. Ly, Shuguang Ma, Roshini Markandu, Rosalinde Masereeuw, J. Eric McDuffie, Kaushik Mitra, Diana Montgomery, Alexandra L. Orton, Katie H. Owens, Axel Pähler, Maria Kristina Parr, Shefali Patel, Ichiko D. Petrie, Richard Phipps, Chandra Prakash, Bhagwat Prasad, Isabelle Ragueneau-Majlessi, Venkatesh Pilla Reddy, Ellen Riddle, Qian Ruan, Simone Schadt, Dhaval K. Shah, Julia Shanu-Wilson, Kelly MacLennan Staiger, Jonathan Steele, Manthena V.S. Varma, Matthew P. Wagoner, Naidong Weng, Stephen Wrigley, Caisheng Wu, Graeme C. Young, Jingjing Yu, Lushan Yu, Su Zeng, Haeyoung Zhang, Wanying Zhang, Andy Z.X. Zhu, Mingshe Zhu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32563bc881f8145ec2036a1b650e62de
https://doi.org/10.1016/b978-0-12-820018-6.09990-7
https://doi.org/10.1016/b978-0-12-820018-6.09990-7
Publikováno v:
Drug Metabolism and Disposition. 45:1133-1138
In hepatic S9 and human liver microsomes (HLMs) the sulfoximine moiety of the ATR inhibitor AZD6738 is metabolized to its corresponding sulfoxide (AZ8982) and sulfone (AZ0002). The initial deimination to AZ8982 is nominally a reductive reaction, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9705649a34b5bf0fdfad246f4a858654
https://doi.org/10.1124/dmd.117.077776
https://doi.org/10.1124/dmd.117.077776
Autor:
Pablo Morentin Gutierrez, Eric Gangl, Dermot F. McGinnity, Pradeep Sharma, Andy Sykes, Teresa Klinowska, Petar Pop-Damkov, James S. Scott, Roshini Markandu, Adrian J. Fretland
Publikováno v:
Cancer Research. 80:1042-1042
AZD9833 is a potent, orally delivered, non-steroidal selective estrogen receptor degrader (SERD) that both antagonizes and degrades ERα. It is currently in clinical testing for the treatment of ER+ metastatic breast cancer (SERENA-1; NCT03616587). W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dc8b6a91c4a5ad4c701678bbbad1068
https://doi.org/10.1158/1538-7445.am2020-1042
https://doi.org/10.1158/1538-7445.am2020-1042